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Laser surgery for mouse geneticists

A rapid, new approach for generating mutant mice from embryonic stem cells may accelerate high-throughput phenotype analysis.

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Figure 1: Comparison of homozygous mutant mouse production by conventional and laser-assisted microinjection procedures.

Kim Caesar

References

  1. Austin, C.P. et al. Nat. Genet. 36, 921–924 (2004).

    Article  CAS  Google Scholar 

  2. Auwerx, J. et al. Nat. Genet. 36, 925–927 (2004).

    Article  CAS  Google Scholar 

  3. Poueymirou, W.T. et al. Nat. Biotechnol. 25, 91–99 (2007).

    Article  CAS  Google Scholar 

  4. Eggan, K. et al. Nat. Biotechnol. 20, 455–459 (2002).

    Article  CAS  Google Scholar 

  5. Tokunaga, T. & Tsunoda, Y. Dev. Growth Differ. 34, 561–566 (1992).

    Article  Google Scholar 

  6. Mortensen, R.M., Conner, D.A., Chao, S., Geisterfer-Lowrance, A.A. & Seidman, J.G. Mol. Cell. Biol. 12, 2391–2395 (1992).

    Article  CAS  Google Scholar 

  7. Abuin, A. & Bradley, A. Mol. Cell. Biol. 16, 1851–1856 (1996).

    Article  CAS  Google Scholar 

  8. Brook, F.A. & Gardner, R.L. Proc. Natl. Acad. Sci. USA 94, 5709–5712 (1997).

    Article  CAS  Google Scholar 

  9. Schoonjans, L. et al. Stem Cells 21, 90–97 (2003).

    Article  Google Scholar 

Download references

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Gridley, T., Woychik, R. Laser surgery for mouse geneticists. Nat Biotechnol 25, 59–60 (2007). https://doi.org/10.1038/nbt0107-59

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