Perspective abstract
Nature Biotechnology 25, 84 - 90 (2007)
Published online: 8 January 2007 | doi:10.1038/nbt1272
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
Paul A Marks1 & Ronald Breslow2
Abstract
In our quest to understand why dimethyl sulfoxide (DMSO) can cause growth arrest and terminal differentiation of transformed cells, we followed a path that led us to discover suberoylanilide hydroxamic acid (SAHA; vorinostat (Zolinza)), which is a histone deacetylase inhibitor. SAHA reacts with and blocks the catalytic site of these enzymes. Extensive structure-activity studies were done along the path from DMSO to SAHA. SAHA can cause growth arrest and death of a broad variety of transformed cells both in vitro and in tumor-bearing animals at concentrations not toxic to normal cells. SAHA has many protein targets whose structure and function are altered by acetylation, including chromatin-associated histones, nonhistone gene transcription factors and proteins involved in regulation of cell proliferation, migration and death. In clinical trials, SAHA has shown significant anticancer activity against both hematologic and solid tumors at doses well tolerated by patients. A new drug application was approved by the US Food and Drug Administration for vorinostat for treatment of cutaneous T-cell lymphoma. More potent analogs of SAHA have shown unacceptable toxicity.
- Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
- Columbia University, Broadway & 116 Street, New York, New York 10028, USA.
Correspondence to: Paul A Marks1 e-mail: marksp@mskcc.org
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drugNature Biotechnology Research (01 Jan 2007)
Cancer biology: mechanism of antitumour action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitorBritish Journal of Cancer Article Response
See all 33 matches for Research
