Volume 25 Issue 1, January 2007

Editorial

The emperor's new clones

Editorial 01 Jan 2007

Advertisement
Burning bridges

Editorial 01 Jan 2007

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News

Upward trend in financing continues, but fewer feel flush

A few large deals have propped up financing numbers for 2006, though IPO activity did pick up by year's end.

Stacy Lawrence
News 05 Jan 2007
Genentech makes its first-ever acquisition

Acquiring Tanox and its asthma franchise gives Genentech an inroad into a new therapeutic area.

Mark Hollmer
News 01 Jan 2007
Biotrin assay to monitor cervical cancer exposure rates

Screening for serotypes will insure success of immunization programs against HPV.

Cormac Sheridan
News 05 Jan 2007
FDA's cloning report bypasses ethics, exposes European dilemma

As the FDA inches toward approving food products from cloned animals, the EU stays mute, setting up another potential trade conflict.

Peter Vermij
News 05 Jan 2007

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News in Brief

News in brief

News in Brief 05 Jan 2007

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News

Profile: Edmund D Pellegrino

The Chairman of The President's Council on Bioethics talks about why scientists and policymakers would be wise to draw on both religion and reason in that endeavor.

Kendall Powell
News 05 Jan 2007

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Data Page

Biotech as an employer

Stacy Lawrence
Data Page 01 Jan 2007

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News Feature

The policy outlook from the Hill

Price controls and a greater role for the US FDA may foreshadow difficult times for the biotech industry in the coming year

Brian Vastag
News Feature 05 Jan 2007
HDAC inhibitors overcome first hurdle

Despite US marketing approval for the first histone deacetylase inhibitor, these prolific agents still have a lot to prove.

Ken Garber
News Feature 05 Jan 2007

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Correspondence

Statistical methods and microarray data

Lev Klebanov
Xing Qiu
Andrei Yakovlev
Correspondence 01 Jan 2007
Reply to Statistical methods and microarray data

Correspondence 01 Jan 2007
MAQC papers over the cracks

Peng Liang
Correspondence 01 Jan 2007
Reply to MAQC papers over the cracks

Correspondence 01 Jan 2007
Unrealistic expectations for IR microspectroscopic imaging

Jens Einenkel
Wolfram Steller
Christoph Krafft
Correspondence 01 Jan 2007
Reply to Unrealistic expectations for IR microspectroscopic imaging

Correspondence 01 Jan 2007
Parallel biopolitical universes

Shane H Morris
Correspondence 01 Jan 2007
Early-tier tests insufficient for GMO risk assessment

Andreas Lang
Éva Lauber
Béla Darvas
Correspondence 01 Jan 2007
Reply to Early-tier tests insufficient for GMO risk assessment

Correspondence 01 Jan 2007

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Commentary

Animal cloning and the FDA—the risk assessment paradigm under public scrutiny

The evidence gathered thus far—ultimately to be published in the Draft Risk Assessment on Animal Cloning—indicates that there are no unique risks associated with animal cloning.

Larisa Rudenko
John C Matheson
Stephen F Sundlof
Commentary 01 Jan 2007

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Investors Lab

The Ten Commandments for biotech investors

Tom Jacobs
Investors Lab 01 Jan 2007

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Book Review

Biotech's promise, delayed

Alice M Sapienza
Book Review 01 Jan 2007

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Feature

Dolly for dinner? Assessing commercial and regulatory trends in cloned livestock

As cloning technologies become more widely established, will products enter the food chain sooner than regulatory agencies and the public might be prepared for?

J Suk
A Bruce
I Papatryfon
Feature 01 Jan 2007

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Patents

Japan's novelty grace period solves the dilemma of 'publish and perish'

Recent changes to Japanese patent law will salvage patent rights for potentially lucrative university-based inventions.

John A Tessensohn
Shusaku Yamamoto
Patents 01 Jan 2007
Recent patent applications in antibodies

Patents 01 Jan 2007

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News & Views

Laser surgery for mouse geneticists

A rapid, new approach for generating mutant mice from embryonic stem cells may accelerate high-throughput phenotype analysis.

Thomas Gridley
Rick Woychik
News & Views 01 Jan 2007
Peptides you can count on

Adjusting for proteotypic peptides offers a way forward for quantitative proteomics.

John JM Bergeron
Michael Hallett
News & Views 01 Jan 2007
A fluid means of stem cell generation

Stem cells in amniotic fluid may represent an attractive alternative to embryonic and adult stem cells.

Alan Trounson
News & Views 01 Jan 2007
Evolving an anti-toxin antibody

The ability to engineer an antibody that specifically binds two epitopes shows promise for therapeutic and diagnostic applications.

Leonard Presta
News & Views 01 Jan 2007
Lentiviral vectors ready for prime-time

The first clinical trial of a lentiviral vector highlights the promise of this new class of gene-therapy vector.

Donald B Kohn
News & Views 01 Jan 2007
Fungal gene clusters

The genome of the fungus that causes corn smut disease has been sequenced.

Ralph A Dean
News & Views 01 Jan 2007
Research Highlights

News & Views 01 Jan 2007

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Analysis

Structure-based maximal affinity model predicts small-molecule druggability

Alan C Cheng
Ryan G Coleman
Enoch S Huang
Analysis 08 Jan 2007

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Perspective

Risk assessment of meat and milk from cloned animals

Xiangzhong Yang
X Cindy Tian
George Seidel Jr
Perspective 08 Jan 2007
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

Paul A Marks
Ronald Breslow
Perspective 08 Jan 2007

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Article

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses

William T Poueymirou
Wojtek Auerbach
David M Valenzuela
Article Open Access 24 Dec 2006
Isolation of amniotic stem cell lines with potential for therapy

Paolo De Coppi
Georg Bartsch Jr
Anthony Atala
Article 07 Jan 2007
Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin

Consuelo Garcia-Rodriguez
Raphael Levy
James D Marks
Article 17 Dec 2006
Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation

Peng Lu
Christine Vogel
Edward M Marcotte
Article 24 Dec 2006

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Letter

Computational prediction of proteotypic peptides for quantitative proteomics

Parag Mallick
Markus Schirle
Ruedi Aebersold
Letter 31 Dec 2006
Production of cattle lacking prion protein

Jürgen A Richt
Poothappillai Kasinathan
Yoshimi Kuroiwa
Letter 31 Dec 2006

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Careers and Recruitment

Masters of efficiency

Manufacturing jobs may be shifting from the large drug companies to contract organizations as firms re-evaluate their strengths. But scientists with analytical skills and an eye for efficiency can find a job transforming materials into medicines.

Hannah Hoag
Careers and Recruitment 01 Jan 2007

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People

People

People 01 Jan 2007

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Volume 25 Issue 1, January 2007

Editorial

News

News in Brief

News

Data Page

News Feature

Correspondence

Commentary

Investors Lab

Book Review

Feature

Patents

News & Views

Analysis

Perspective

Article

Letter

Careers and Recruitment

People

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