This focus presents the first formal results of the MicroArray Quality Control (MAQC) project, an unprecedented, community-wide effort, under the auspices of the FDA, with the goal of experimentally addressing the key issues surrounding the reliability of DNA microarray data and establishing operational metrics to objectively assess the performance of seven microarray platforms. Ultimately, it is hoped that the MAQC effort will provide the research and regulatory communities with a foundation from which to derive the necessary guidelines for using microarrays in clinical practice and regulatory decision-making.
Companies eye slice of age-related macular degeneration marketpp1041 - 1042 Emily Waltz Published online: 01 September 2006|doi:10.1038/nbt0906-1041 Abstract|Full text|PDF
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New clinical trials policy at FDAp1043 Brian Vastag Published online: 01 September 2006|doi:10.1038/nbt0906-1043 Full text|PDF
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Amgen's TPO mimic faces stiff competitionp1044 Stacy Lawrence Published online: 01 September 2006|doi:10.1038/nbt0906-1044 Full text|PDF
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BioXell: an Italian biotech success story?pp1045 - 1046 Cormac Sheridan Published online: 01 September 2006|doi:10.1038/nbt0906-1045 Full text|PDF
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In Brief
News In Briefpp1048 - 1049Published online: 01 September 2006| doi:10.1038/nbt0706-1048 Full text|PDF
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Profile: Abe Abuchowskip1050 Alla Katsnelson Published online: 01 September 2006|doi:10.1038/nbt0906-1050 Abstract|Full text|PDF
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Data Page
Biotech R&D goes further afieldp1052 Stacey Lawrence doi:10.1038/nbt0906-1052 Full text|PDF
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News Feature
Systems Biology, Incorporated?pp1055 - 1057 Karl Thiel Published online: 01 September 2006|doi:10.1038/nbt0906-1055 Abstract|Full text|PDF
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The promise of the East: India and China as R&D optionspp1061 - 1064 Simon Goodall, Bart Janssens, Kim Wagner, John Wong, Wendy Woods & Michael Yeh Published online: 25 July 2006|doi:10.1038/bioent910 Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent) PDF
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How to stay out of a BINDp1065 William B Busa doi:10.1038/nbt0906-1065a Full text|PDF
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The dog as a cancer modelpp1065 - 1066 Chand Khanna, Kerstin Lindblad-Toh, David Vail, Cheryl London, Philip Bergman, Lisa Barber, Matthew Breen, Barbara Kitchell, Elizabeth McNeil, Jaime F Modiano, Steven Niemi, Kenine E Comstock, Elaine Ostrander, Susan Westmoreland & Stephen Withrow doi:10.1038/nbt0906-1065b Full text|PDF
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GM sterile mosquitoes—a cautionary notepp1067 - 1068 Bart G J Knols, Rebecca C Hood-Nowotny, Hervé Bossin, Gerald Franz, Alan Robinson, Wolfgang R Mukabana & Samuel K Kemboi doi:10.1038/nbt0906-1067 Full text|PDF
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Reply to GM sterile mosquitoes—a cautionary notep1068 doi:10.1038/nbt0906-1068a Full text|PDF
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Sequencing errors or SNPs at splice-acceptor guanines in dbSNP?pp1068 - 1070 Matthias Platzer, Michael Hiller, Karol Szafranski, Niels Jahn, Jochen Hampe, Stefan Schreiber, Rolf Backofen & Klaus Huse doi:10.1038/nbt0906-1068b Full text|PDF
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Data integration gets 'Sloppy'pp1070 - 1071 Jonas S Almeida, Chuming Chen, Robert Gorlitsky, Romesh Stanislaus, Marta Aires-de-Sousa, Pedro Eleutério, João Carriço, António Maretzek, Andreas Bohn, Allen Chang, Fan Zhang, Rahul Mitra, Gordon B Mills, Xiaoshu Wang & Helena F Deus doi:10.1038/nbt0906-1070 Full text|PDF
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Replacing cRNA targets with cDNA reduces microarray cross-hybridizationpp1071 - 1073 Aron C Eklund, Leah R Turner, Pengchin Chen, Roderick V Jensen, Gianfranco deFeo, Anne R Kopf-Sill & Zoltan Szallasi doi:10.1038/nbt0906-1071 Full text|PDF
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Commentary
Why spurning food biotech has become a liabilitypp1075 - 1077 Henry I Miller, Gregory Conko & Drew L Kershen doi:10.1038/nbt0906-1075 Abstract|Full text|PDF
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The breeder's dilemma—yield or nutrition?pp1078 - 1080 Cindy E Morris & David C Sands doi:10.1038/nbt0906-1078 Abstract|Full text|PDF
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Investor's Lab
The protection racketp1081 Tom Jacobs doi:10.1038/nbt0906-1081 Full text|PDF
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Oversight of US genetic testing laboratoriespp1083 - 1090 Kathy L Hudson, Juli A Murphy, David J Kaufman, Gail H Javitt, Sara H Katsanis & Joan Scott doi:10.1038/nbt0906-1083 Abstract|Full text|PDF
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Patents
Evidence and anecdotes: an analysis of human gene patenting controversiespp1091 - 1094 Timothy Caulfield, Robert M Cook-Deegan, F Scott Kieff & John P Walsh doi:10.1038/nbt0906-1091 Abstract|Full text|PDF
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Recent patent applications in tissue engineeringp1095 doi:10.1038/nbt0906-1095 Full text|PDF
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Artificial sperm and epigenetic reprogrammingpp1097 - 1098 Diana Lucifero & Wolf Reik doi:10.1038/nbt0906-1097 Abstract|Full text|PDF
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The worm turns for antimicrobial discoverypp1098 - 1100 Amit P Bhavsar & Eric D Brown doi:10.1038/nbt0906-1098 Abstract|Full text|PDF
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The sweet side of biomarker discoverypp1100 - 1101 Carlos J Bosques, S Raguram & Ram Sasisekharan doi:10.1038/nbt0906-1100 Abstract|Full text|PDF
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Microarray Quality Control Empowering microarrays in the regulatory settingp1103 Daniel A. Casciano & Janet Woodcock doi:10.1038/nbt0906-1103 Full text|PDF
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Microarray Quality Control Impact of microarray data quality on genomic data submissions to the FDApp1105 - 1107 Felix W Frueh doi:10.1038/nbt0906-1105 Abstract|Full text|PDF
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Microarray Quality Control A framework for the use of genomics data at the EPApp1108 - 1111 David J Dix, Kathryn Gallagher, William H Benson, Brenda L Groskinsky, J Thomas McClintock, Kerry L Dearfield & William H Farland doi:10.1038/nbt0906-1108 Abstract|Full text|PDF
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Microarray Quality Control Data quality in genomics and microarrayspp1112 - 1113 Hanlee Ji & Ronald W Davis doi:10.1038/nbt0906-1112 Abstract|Full text|PDF
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Microarray Quality Control Evaluation of DNA microarray results with quantitative gene expression platformspp1115 - 1122 Roger D Canales, Yuling Luo, James C Willey, Bradley Austermiller, Catalin C Barbacioru, Cecilie Boysen, Kathryn Hunkapiller, Roderick V Jensen, Charles R Knight, Kathleen Y Lee, Yunqing Ma, Botoul Maqsodi, Adam Papallo, Elizabeth Herness Peters, Karen Poulter, Patricia L Ruppel, Raymond R Samaha, Leming Shi, Wen Yang, Lu Zhang & Federico M Goodsaid Published online: 08 September 2006|doi:10.1038/nbt1236 Abstract|Full text|PDF
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Microarray Quality Control Using RNA sample titrations to assess microarray platform performance and normalization techniquespp1123 - 1131 Richard Shippy, Stephanie Fulmer-Smentek, Roderick V Jensen, Wendell D Jones, Paul K Wolber, Charles D Johnson, P Scott Pine, Cecilie Boysen, Xu Guo, Eugene Chudin, Yongming Andrew Sun, James C Willey, Jean Thierry-Mieg, Danielle Thierry-Mieg, Robert A Setterquist, Mike Wilson, Anne Bergstrom Lucas, Natalia Novoradovskaya, Adam Papallo, Yaron Turpaz, Shawn C Baker, Janet A Warrington, Leming Shi & Damir Herman Published online: 08 September 2006|doi:10.1038/nbt1241 Abstract|Full text|PDF
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Microarray Quality Control Evaluation of external RNA controls for the assessment of microarray performancepp1132 - 1139 Weida Tong, Anne Bergstrom Lucas, Richard Shippy, Xiaohui Fan, Hong Fang, Huixiao Hong, Michael S Orr, Tzu-Ming Chu, Xu Guo, Patrick J Collins, Yongming Andrew Sun, Sue-Jane Wang, Wenjun Bao, Russell D Wolfinger, Svetlana Shchegrova, Lei Guo, Janet A Warrington & Leming Shi Published online: 09 August 2006|doi:10.1038/nbt1237 Abstract|Full text|PDF
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|Supplementary Information
Microarray Quality Control Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) projectpp1140 - 1150 Tucker A Patterson, Edward K Lobenhofer, Stephanie B Fulmer-Smentek, Patrick J Collins, Tzu-Ming Chu, Wenjun Bao, Hong Fang, Ernest S Kawasaki, Janet Hager, Irina R Tikhonova, Stephen J Walker, Liang Zhang, Patrick Hurban, Francoise de Longueville, James C Fuscoe, Weida Tong, Leming Shi & Russell D Wolfinger Published online: 08 September 2006|doi:10.1038/nbt1242 Abstract|Full text|PDF
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Articles
Microarray Quality Control The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurementspp1151 - 1161 MAQC Consortium (Leming Shi, Laura H Reid, Wendell D Jones, Richard Shippy, Janet A Warrington, Shawn C Baker, Patrick J Collins, Francoise de Longueville, Ernest S Kawasaki, Kathleen Y Lee, Yuling Luo, Yongming Andrew Sun, James C Willey, Robert A Setterquist, Gavin M Fischer, Weida Tong, Yvonne P Dragan, David J Dix, Felix W Frueh, Federico M Goodsaid, Damir Herman, Roderick V Jensen, Charles D Johnson, Edward K Lobenhofer, Raj K Puri, Uwe Scherf, Jean Thierry-Mieg, Charles Wang, Mike Wilson, Paul K Wolber, Lu Zhang, Shashi Amur, Wenjun Bao, Catalin C Barbacioru, Anne Bergstrom Lucas, Vincent Bertholet, Cecilie Boysen, Bud Bromley, Donna Brown, Alan Brunner, Roger Canales, Xiaoxi Megan Cao, Thomas A Cebula, James J Chen, Jing Cheng, Tzu-Ming Chu, Eugene Chudin, John Corson, J Christopher Corton, Lisa J Croner, Christopher Davies, Timothy S Davison, Glenda Delenstarr, Xutao Deng, David Dorris, Aron C Eklund, Xiao-hui Fan, Hong Fang, Stephanie Fulmer-Smentek, James C Fuscoe, Kathryn Gallagher, Weigong Ge, Lei Guo, Xu Guo, Janet Hager, Paul K Haje, Jing Han, Tao Han, Heather C Harbottle, Stephen C Harris, Eli Hatchwell, Craig A Hauser, Susan Hester, Huixiao Hong, Patrick Hurban, Scott A Jackson, Hanlee Ji, Charles R Knight, Winston P Kuo, J Eugene LeClerc, Shawn Levy, Quan-Zhen Li, Chunmei Liu, Ying Liu, Michael J Lombardi, Yunqing Ma, Scott R Magnuson, Botoul Maqsodi, Tim McDaniel, Nan Mei, Ola Myklebost, Baitang Ning, Natalia Novoradovskaya, Michael S Orr, Terry W Osborn, Adam Papallo, Tucker A Patterson, Roger G Perkins, Elizabeth H Peters, Ron Peterson, Kenneth L Philips, P Scott Pine, Lajos Pusztai, Feng Qian, Hongzu Ren, Mitch Rosen, Barry A Rosenzweig, Raymond R Samaha, Mark Schena, Gary P Schroth, Svetlana Shchegrova, Dave D Smith, Frank Staedtler, Zhenqiang Su, Hongmei Sun, Zoltan Szallasi, Zivana Tezak, Danielle Thierry-Mieg, Karol L Thompson, Irina Tikhonova, Yaron Turpaz, Beena Vallanat, Christophe Van, Stephen J Walker, Sue Jane Wang, Yonghong Wang, Russ Wolfinger, Alex Wong, Jie Wu, Chunlin Xiao, Qian Xie, Jun Xu, Wen Yang, Liang Zhang, Sheng Zhong, Yaping Zong & William Slikker Jr) Published online: 08 September 2006|doi:10.1038/nbt1239 Abstract|Full text|PDF
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Microarray Quality Control Rat toxicogenomic study reveals analytical consistency across microarray platformspp1162 - 1169 Lei Guo, Edward K Lobenhofer, Charles Wang, Richard Shippy, Stephen C Harris, Lu Zhang, Nan Mei, Tao Chen, Damir Herman, Federico M Goodsaid, Patrick Hurban, Kenneth L Phillips, Jun Xu, Xutao Deng, Yongming Andrew Sun, Weida Tong, Yvonne P Dragan & Leming Shi Published online: 08 September 2006|doi:10.1038/nbt1238 Abstract|Full text|PDF
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Corrigendum: All in the RNA familyp1170 Beverly L. Davidson doi:10.1038/nbt0906-1170c Full text|PDF
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Corrigendum: Engineering and characterization of a superfolder green fluorescent proteinp1170 Jean-Denis Pe´delacq, Stéphanie Cabantous, Timothy Tran, Thomas C Terwilliger & Geoffrey S Waldo doi:10.1038/nbt0906-1170d Full text|PDF
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Retraction: Identification of genes that function in the TNF--mediated apoptotic pathway using randomized hybrid ribozyme librariesp1170 Hiroaki Kawasaki, Reiko Onuki, Eigo Suyama & Kazunari Taira doi:10.1038/nbt0906-1170e Full text|PDF
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-mediated apoptotic pathway using randomized hybrid ribozyme libraries
