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Journal home Advance online publication Current issue Archive Press releases Supplements Focuses Conferences Guide to authors Online submission Permissions For referees Free online issue Contact the journal Subscribe Advertising work@npg naturereprints About this site For librarians   NPG Resources Bioentrepreneur Nature Reviews Drug Discovery Nature Nature Medicine Nature Genetics Nature Reviews Genetics Nature Methods Nature Chemical Biology news@nature.com Clinical Pharmacology & Therapeutics Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Biotechnology - 24, 954 - 955 (2006) doi:10.1038/nbt0806-954 Specificity by design Carl O Pabo Carl O. Pabo is a visiting professor in the Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, WAB 536, Boston, Massachusetts 02115, USA. pabo@hms.harvard.edu The specificity of a homing endonuclease has been altered using computational modeling of the protein-DNA interface. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. RESEARCH Computational redesign of endonuclease DNA binding and cleavage specificity Nature Letters to Editor (01 Jun 2006) Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases Nature Letters to Editor (06 Nov 2008) An improved zinc-finger nuclease architecture for highly specific genome editing Nature Biotechnology Research (01 Jul 2007) Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor Nature Structural & Molecular Biology Article (01 Oct 2004) Exploitation of binding energy for catalysis and design Nature Letters to Editor (29 Oct 2009) See all 7 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Rights and permissions Order commercial reprints Save this link Figures & Tables Export citation Open Innovation Challenges Novel Approaches to Protecting Maize from Insect Damage Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re... Methods of Modeling Adaptation in Populations Deadline: Dec 30 2009 Reward: $15,000 USD The analysis of adaptation with a population is a frequently encountered computational modeling scen... More Challenges Powered by: nature jobs Post Doctoral Research Associate University of Illinois Urbana United States Senior Faculty Positions Torrey Pines Institute for Molecular Studies Port St. Lucie, FL More science jobs Post a job for free Search buyers guide:

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