Nature Biotechnology 24, 817 - 819 (2006)
Published online: 11 June 2006; | doi:10.1038/nbt1215
A consensus epitope prediction approach identifies the breadth of murine TCD8+-cell responses to vaccinia virusMagdalini Moutaftsi1, Bjoern Peters1, Valerie Pasquetto1, David C Tscharke2, John Sidney1, Huynh-Hoa Bui1, Howard Grey1
& Alessandro Sette11
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, California 92109, USA. 2
Division of Immunology and Infectious Diseases, Queensland Institute of Medical Research, Herston, Australia.
Correspondence should be addressed to Alessandro Sette alex@liai.org The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.
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