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Research
Nature Biotechnology 24, 582–586 (1 June 2006) | doi:10.1038/nbt1204
Statistical pattern matching facilitates the design of polyvalent inhibitors of anthrax and cholera toxins
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Abstract
Numerous biological processes involve the recognition of a specific pattern of binding sites on a target protein or surface. Although ligands displayed by disordered scaffolds form stochastic rather than specific patterns, theoretical models predict that recognition will occur between patterns that are characterized by similar or “matched” statistics.
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