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Nature Biotechnology
ISSUE
April 2006, Volume 24 No 4
In This Issue
Editorials
NewsIn Brief | Data Page | News Feature
BioentrepreneurBioenews | Building a business
Opinion and CommentCorrespondence | Commentary | Investor's Lab
FeaturesPatents
News and Views
Computational BiologyPrimer | Review
ResearchBrief Communications | Articles | Letters
Corrigenda
Errata
NaturejobsCareers and Recruitment | People
About the cover
In This Issue Top
PDF
Editorials Top
The end of the beginning? p367
doi:10.1038/nbt0406-367
Full text | PDF (63K)
Consequences p368
doi:10.1038/nbt0406-368a
Full text | PDF (44K)
Transgenic milk prospects turn sour p368
doi:10.1038/nbt0406-368b
Full text | PDF (44K)
News Top
First inhalable insulin approved pp369 - 370
Alla Katsnelson
Published online: 29 March 2006 | doi:10.1038/nbt0406-369
Full text | PDF (105K)
Complement inhibitors finally find orphan niches pp371 - 372
Mark Ratner
Published online: 29 March 2006 | doi:10.1038/nbt0406-371
Full text | PDF (123K)
Hedge funds gain edge by doubling biotech investments pp373 - 374
John Ransom
Published online: 29 March 2006 | doi:10.1038/nbt0406-373
Full text | PDF (119K)
China kickstarts its vaccine market p375
Hepeng Jia
Published online: 29 March 2006 | doi:10.1038/nbt0406-375
Full text | PDF (108K)
In Brief
News In Brief pp377 - 378Published online: 29 March 2006 | 
doi:10.1038/nbt0406-377
Full text | PDF (109K)
Data Page
Agbiotech goes further afield p379
Stacy Lawrence
doi:10.1038/nbt0406-379
Full text | PDF (132K)
Trends in biotech literature 2005 p380
Stacy Lawrence
doi:10.1038/nbt0406-380
Full text | PDF (123K)
News Feature
BIO reaches adolescence pp381 - 383
Jeffrey L. Fox
Published online: 29 March 2006 | doi:10.1038/nbt0406-381
Abstract | Full text | PDF (105K)
Bioentrepreneur  Top
Bioenews
IBM opens the IP vaults pp385 - 386
George S Mack
Published online: 03 February 2006 | doi:10.1038/bioent902
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)

PDF (88K)
Building a business
Why media relations matter pp387 - 389
Joan E Kureczka
Published online: 20 March 2006 | doi:10.1038/bioent906
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)

PDF (88K)
Opinion and Comment Top
Correspondence
An international gap in human ES cell research pp391 - 392
Jason Owen-Smith & Jennifer McCormick
doi:10.1038/nbt0406-391
Full text | PDF (104K)  | Supplementary Information
Hwang's fraud adds impetus to ES cell research p393
Xiangzhong Yang
doi:10.1038/nbt0406-393a
Full text | PDF (112K)
Are Europeans really antagonistic to biotech? pp393 - 395
Rafael Pardo & Felix Calvo
doi:10.1038/nbt0406-393b
Full text | PDF (179K)  | Supplementary Information
Low-lignin wood—a case study pp395 - 396
Kana Talukder
doi:10.1038/nbt0406-395
Full text | PDF (102K)
Commentary
Can science resolve the ethical impasse in stem cell research? pp397 - 400
Evan Y Snyder, Lawrence M Hinman & Michael W Kalichman
doi:10.1038/nbt0406-397
Abstract | Full text | PDF (270K)
Investor's Lab
My worst biotech investment p401
Tom Jacobs
doi:10.1038/nbt0406-401
Full text | PDF (57K)
Features Top
Putting pharmacogenetics into practice pp403 - 410
Michael M Hopkins, Dolores Ibarreta, Sibylle Gaisser, Christien M Enzing, Jim Ryan, Paul A Martin, Graham Lewis, Symone Detmar, M Elske van den Akker-van Marle, Adam M Hedgecoe, Paul Nightingale, Marieke Dreiling, K Juliane Hartig, Wieneke Vullings & Tony Forde
doi:10.1038/nbt0406-403
Abstract | Full text | PDF (237K)  | Supplementary Information
Patents
The paths around stem cell intellectual property pp411 - 413
Kenneth S Taymor, Christopher Thomas Scott & Henry T Greely
doi:10.1038/nbt0406-411
Abstract | Full text | PDF (142K)
Recent patent applications in stem cell research p414
doi:10.1038/nbt0406-414
Full text | PDF (39K)
News and Views Top
Ion-channel drug screening galvanized pp415 - 416
Paul B Bennett
doi:10.1038/nbt0406-415
Abstract | Full text | PDF (108K)
See also: Research by Huang et al.
A peptide chaperone for transdermal drug delivery pp416 - 417
Mark R Prausnitz
doi:10.1038/nbt0406-416
Abstract | Full text | PDF (146K)
See also: Research by Chen et al.
Breeding new life into plant metabolism pp418 - 419
James J Giovannoni
doi:10.1038/nbt0406-418
Abstract | Full text | PDF (208K)
See also: Research by Schauer et al.
Do targets limit antibiotic discovery? pp419 - 420
Molly B Schmid
doi:10.1038/nbt0406-419
Abstract | Full text | PDF (104K)
Research Highlights p421
doi:10.1038/nbt0406-421
Full text | PDF (114K)
Computational Biology Top
Primer
What are DNA sequence motifs? pp423 - 425
Patrik D'haeseleer
doi:10.1038/nbt0406-423
Abstract | Full text | PDF (211K)
Review
Modeling cellular machinery through biological network comparison pp427 - 433
Roded Sharan & Trey Ideker
Published online: 06 April 2006 | doi:10.1038/nbt1196
Abstract | Full text | PDF (531K)
Research Top
Brief Communications
Generation of cloned transgenic pigs rich in omega-3 fatty acids pp435 - 436
Liangxue Lai, Jing X Kang, Rongfeng Li, Jingdong Wang, William T Witt, Hwan Yul Yong, Yanhong Hao, David M Wax, Clifton N Murphy, August Rieke, Melissa Samuel, Michael L Linville, Scott W Korte, Rhobert W Evans, Thomas E Starzl, Randall S Prather & Yifan Dai
Published online: 26 March 2006 | doi:10.1038/nbt1198
Abstract | Full text | PDF (128K)  | Supplementary Information
Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device pp437 - 438
James H Prescott, Sara Lipka, Samuel Baldwin, Norman F Sheppard Jr., John M Maloney, Jonathan Coppeta, Barry Yomtov, Mark A Staples & John T Santini Jr.
Published online: 12 March 2006 | doi:10.1038/nbt1199
Abstract | Full text | PDF (163K)  | Supplementary Information
Articles
Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential pp439 - 446
Chien-Jung Huang, Alec Harootunian, Michael P Maher, Catherine Quan, Christopher D Raj, Ken McCormack, Randal Numann, Paul A Negulescu & Jesús E González
Published online: 19 March 2006 | doi:10.1038/nbt1194
Abstract | Full text | PDF (827K)
See also: News and Views by Bennett
Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement pp447 - 454
Nicolas Schauer, Yaniv Semel, Ute Roessner, Amit Gur, Ilse Balbo, Fernando Carrari, Tzili Pleban, Alicia Perez-Melis, Claudia Bruedigam, Joachim Kopka, Lothar Willmitzer, Dani Zamir & Alisdair R Fernie
Published online: 12 March 2006 | doi:10.1038/nbt1192
Abstract | Full text | PDF (578K)  | Supplementary Information
See also: News and Views by Giovannoni
Letters
Transdermal protein delivery by a coadministered peptide identified via phage display pp455 - 460
Yongping Chen, Yuanyuan Shen, Xin Guo, Caoshou Zhang, Wenjuan Yang, Minglu Ma, Shu Liu, Maobin Zhang & Long-Ping Wen
Published online: 26 March 2006 | doi:10.1038/nbt1193
Abstract | Full text | PDF (331K)  | Supplementary Information
See also: News and Views by Prausnitz
Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light pp461 - 465
Nadya G Gurskaya, Vladislav V Verkhusha, Alexander S Shcheglov, Dmitry B Staroverov, Tatyana V Chepurnykh, Arkady F Fradkov, Sergey Lukyanov & Konstantin A Lukyanov
Published online: 19 March 2006 | doi:10.1038/nbt1191
Abstract | Full text | PDF (468K)  | Supplementary Information
Corrigenda Top
Corrigendum: Biocontrol genome deciphered p466
Dieter Haas
doi:10.1038/nbt0406-466a
Full text | PDF (158K)
Corrigendum: Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5 p466
Ian T Paulsen, Caroline M Press, Jacques Ravel, Donald Y Kobayashi, Garry S A Myers, Dmitri V Mavrodi, Robert T DeBoy, Rekha Seshadri, Qinghu Ren, Ramana Madupu, Robert J Dodson, A Scott Durkin, Lauren M Brinkac, Sean C Daugherty, Stephen A Sullivan, Mary J Rosovitz, Michelle L Gwinn, Liwei Zhou, Davd J Schneider, Samuel W Cartinhour, William C Nelson, Janice Weidman, Kisha Watkins, Kevin Tran, Hoda Khouri, Elizabeth A Pierson, Leland S Pierson III, Linda S Thomashow & Joyce E Loper
doi:10.1038/nbt0406-466b
Full text | PDF (158K)
Errata Top
Erratum: Biotech entrepreneur, educate thyself! p467
Emily Waltz
doi:10.1038/nbt0406-467a
Full text | PDF (46K)
Erratum: European GMO labeling thresholds impractical and unscientific p467
Florian Weighardt
doi:10.1038/nbt0406-467b
Full text | PDF (46K)
Erratum: Biotech entrepreneur, educate thyself! p467
Emily Waltz
doi:10.1038/nbt0406-467c
Full text | PDF (46K)
Erratum: Biogenerics at the crossroads p467
Carole S Ben-Maimon & Rob Garnick
doi:10.1038/nbt0406-467d
Full text | PDF (46K)
Naturejobs Top
Careers and Recruitment
What are you worth? pp469 - 470
Mary Yaroshevsky-Glanville
doi:10.1038/nbt0406-469
Abstract | Full text | PDF (112K)
People
People p472
doi:10.1038/nbt0406-472
Full text | PDF (64K)
  Top
 
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Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
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