Nature Biotechnology 24, 437 - 438 (2006)
Published online: 12 March 2006; | doi:10.1038/nbt1199
Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip deviceJames H Prescott1, 2, Sara Lipka1, 2, Samuel Baldwin1, Norman F Sheppard Jr.1, John M Maloney1, Jonathan Coppeta1, Barry Yomtov1, Mark A Staples1
& John T Santini Jr.11
MicroCHIPS Inc., 6-B Preston Court, Bedford, Massachusetts 01730, USA. 2
These authors contributed equally to this work.
Correspondence should be addressed to John T Santini Jr. jsantini@mchips.com Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.
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