Nature Biotechnology 24, 435 - 436 (2006)
Published online: 26 March 2006; | doi:10.1038/nbt1198
Generation of cloned transgenic pigs rich in omega-3 fatty acidsLiangxue Lai1, 2, 8, Jing X Kang5, 8, Rongfeng Li1, Jingdong Wang5, William T Witt6, Hwan Yul Yong1, Yanhong Hao1, David M Wax1, Clifton N Murphy1, August Rieke1, Melissa Samuel1, Michael L Linville3, Scott W Korte4, Rhobert W Evans7, Thomas E Starzl6, Randall S Prather1, 2
& Yifan Dai61
Division of Animal Science, University of Missouri-Columbia, Columbia, Missouri 65211, USA. 2
National Swine Resource and Research Center, University of Missouri-Columbia, Columbia, Missouri 65211, USA. 3
Office of Animal Resources, University of Missouri-Columbia, Columbia, Missouri 65211, USA. 4
Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, Missouri 65211, USA. 5
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. 6
Thomas Starzl Transplantation Institute, Department of Surgery, GSPH, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. 7
Department of Epidemiology, GSPH, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. 8
These authors contributed equally to this work.
Correspondence should be addressed to Yifan Dai daiy@upmc.edu or Randall S Prather pratherr@missouri.edu Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
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