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Nature Biotechnology 24, 198 - 204 (2006)
Published online: 22 January 2006; | doi:10.1038/nbt1182

Directed evolution of adeno-associated virus yields enhanced gene delivery vectors

Narendra Maheshri, James T Koerber, Brian K Kaspar & David V Schaffer

Supplementary Fig. 1 (pdf 20K)
Heparin binding characterization of individual clones.

Supplementary Fig. 2 (pdf 20K)
Heparin chromatograms of antibody evading mutants.

Supplementary Fig. 3 (pdf 16K)
Neutralization profile of selected AbE mutants on a second rabbit serum source.

Supplementary Fig. 4 (pdf 16K)
Neutralization profile of heat-inactivated serum.

Supplementary Table 1 (pdf 8K)
Titers of antibody escape mutants.

Supplementary Note (pdf 20K)
The neutralization assay.


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Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
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