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| This issue provides several articles focusing on antibacterial research and development. Additional material, brought together in a joint focus with Nature Reviews Drug Discovery supported by AstraZeneca and Wyeth Pharmaceuticals, is also available by clicking on the box "Joint Focus" above. |
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| Editorials | Top |
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A billion dollar punt p1453
doi:10.1038/nbt1206-1453
Abstract | Full text | PDF
(81K)
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All together now? p1454
doi:10.1038/nbt1206-1454
Abstract | Full text | PDF
(45K)
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| News | Top |
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Biotech takes aim at large anti-estrogen markets pp1455 - 1456
Mark Hollmer
doi:10.1038/nbt1206-1455
Abstract | Full text | PDF
(153K)
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Niche indications could drive higher valuations p1457
John Ransom
Published online: 06 December 2006 | doi:10.1038/nbt1206-1457
Abstract | Full text | PDF
(95K)
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European pharma consolidation generates quality spinoffs pp1458 - 1459
Cormac Sheridan
Published online: 06 December 2006 | doi:10.1038/nbt1206-1458
Abstract | Full text | PDF
(185K)
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Danish biotech outperforms its European counterparts pp1460 - 1461
Nuala Moran
Published online: 06 December 2006 | doi:10.1038/nbt1206-1460
Abstract | Full text | PDF
(165K)
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| In Brief |
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News in brief pp1463 - 1464Published online: 06 December 2006 |
doi:10.1038/nbt1206-1463
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(135K)
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Profile: Daphne Zohar p1465
Mark Ratner
Published online: 06 December 2006 | doi:10.1038/nbt1206-1465
Abstract | Full text | PDF
(77K)
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| Data Page |
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Biotech blockbusters consolidate markets p1466
Stacy Lawrence
doi:10.1038/nbt1206-1466
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(102K)
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| Bioentrepreneur | Top |
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| Building a business |
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Getting it right the first time pp1467 - 1469
Barbara M. Johnson
Published online: 23 October 2006 | doi:10.1038/bioent913
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(106K)
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| Opinion and Comment | Top |
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| Correspondence |
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NCBI GEO standards and services for microarray data pp1471 - 1472
Ron Edgar & Tanya Barrett
doi:10.1038/nbt1206-1471
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(274K)
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Why the omega-3 piggy should not go to market pp1472 - 1473
Autumn Fiester
doi:10.1038/nbt1206-1472
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(123K)
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Maximizing state and federal spending while minimizing conflicts pp1473 - 1474
Melvin L Billingsley & Michele Washko
doi:10.1038/nbt1206-1473
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(177K)
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The art of gene function prediction pp1474 - 1475
T M Murali, Chang-Jiun Wu & Simon Kasif
doi:10.1038/nbt1206-1474
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(213K)
| Supplementary Information |
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Reply to "The art of gene function prediction" pp1475 - 1476
doi:10.1038/nbt1206-1475
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(138K)
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Reproducibility Probability Score—incorporating measurement variability across laboratories for gene selection pp1476 - 1477
Guixian Lin, Xuming He, Hanlee Ji, Leming Shi, Ronald W Davis & Sheng Zhong
doi:10.1038/nbt1206-1476
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(170K)
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| Investor's Lab |
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Is there balm in Gilead? p1478
Tom Jacobs
doi:10.1038/nbt1206-1478
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(57K)
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| Book Review |
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The real deal p1479
Reviewed by: Harvey Bialy
doi:10.1038/nbt1206-1479
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(69K)
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| News and Views | Top |
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Towards cell therapy for diabetes pp1481 - 1483
Ole D Madsen & Palle Serup
doi:10.1038/nbt1206-1481
Abstract | Full text | PDF
(1,407K)
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A new lease on life for dendritic cell vaccines? pp1483 - 1484
Frank O Nestle
doi:10.1038/nbt1206-1483
Abstract | Full text | PDF
(120K)
See also: Research by Park et al. |
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Profile of a bacterial tumor killer pp1484 - 1485
Neil S Forbes
doi:10.1038/nbt1206-1484
Abstract | Full text | PDF
(718K)
See also: Research by Bettegowda et al. |
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Research Highlights p1487
doi:10.1038/nbt1206-1487
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(82K)
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| Editorial | Top |
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Focus on Antibacterials
Bring the magic back to the bullets p1489
doi:10.1038/nbt1206-1489
Abstract | Full text | PDF
(86K)
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| News | Top |
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Focus on Antibacterials
Anti-infective antibodies: finding the path forward pp1491 - 1493
Monya Baker
Published online: 06 December 2006 | doi:10.1038/nbt1206-1491
Abstract | Full text | PDF
(118K)
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Focus on Antibacterials
Antibiotics au naturel pp1494 - 1496
Cormac Sheridan
Published online: 06 December 2006 | doi:10.1038/nbt1206-1494
Abstract | Full text | PDF
(836K)
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| Opinion and Comment | Top |
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| Commentary |
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Focus on Antibacterials
Antibacterial discovery and development—the failure of success? pp1497 - 1503
Prabhavathi Fernandes
doi:10.1038/nbt1206-1497
Abstract | Full text | PDF
(394K)
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Focus on Antibacterials
Prospects for plant-derived antibacterials pp1504 - 1507
Kim Lewis & Frederick M Ausubel
doi:10.1038/nbt1206-1504
Abstract | Full text | PDF
(316K)
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Focus on Antibacterials
Reinventing phage therapy: are the parts greater than the sum? pp1508 - 1511
Vincent A Fischetti, Daniel Nelson & Raymond Schuch
doi:10.1038/nbt1206-1508
Abstract | Full text | PDF
(215K)
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Focus on Antibacterials
Antibiotics—an investment worth making? pp1512 - 1514
Ralph E Christoffersen
doi:10.1038/nbt1206-1512
Abstract | Full text | PDF
(149K)
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Focus on Antibacterials
Moving goalposts—regulatory oversight of antibacterial drugs pp1515 - 1519
Randall Brenner, Evelyn J Ellis-Grosse & Roger Echols
doi:10.1038/nbt1206-1515
Abstract | Full text | PDF
(1,200K)
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The pharma company view pp1515 - 1519
Randall Brenner & Evelyn J Ellis-Grosse
doi:10.1038/nbt1206-1515
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(1,200K)
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Moving goalposts—regulatory oversightof antibacterial drugs pp1519 - 1520
Roger Echols
doi:10.1038/nbt1206-1519
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(125K)
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| Features | Top |
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Focus on Antibacterials
The business of developing antibacterials pp1521 - 1528
Jeffrey L Fox
doi:10.1038/nbt1206-1521
Abstract | Full text | PDF
(238K)
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| Patents |
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Focus on Antibacterials
Where have all the antibiotic patents gone? pp1529 - 1531
Martin L Katz, Lisa V Mueller, Mark Polyakov & Steven F Weinstock
doi:10.1038/nbt1206-1529
Abstract | Full text | PDF
(107K)
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Focus on Antibacterials
Recent patent applications related to antibacterials p1532
doi:10.1038/nbt1206-1532
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(40K)
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| Research | Top |
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| Reviews |
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Focus on Antibacterials
Molecular engineering approaches to peptide, polyketide and other antibiotics pp1533 - 1540
Richard H Baltz
Published online: 11 December 2006 | doi:10.1038/nbt1265
Abstract | Full text | PDF
(273K)
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Focus on Antibacterials
New antibiotics from bacterial natural products pp1541 - 1550
Jon Clardy, Michael A Fischbach & Christopher T Walsh
Published online: 11 December 2006 | doi:10.1038/nbt1266
Abstract | Full text | PDF
(398K)
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Focus on Antibacterials
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies pp1551 - 1557
Robert E W Hancock & Hans-Georg Sahl
Published online: 11 December 2006 | doi:10.1038/nbt1267
Abstract | Full text | PDF
(326K)
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Focus on Antibacterials
Riboswitches as antibacterial drug targets pp1558 - 1564
Kenneth F Blount & Ronald R Breaker
Published online: 11 December 2006 | doi:10.1038/nbt1268
Abstract | Full text | PDF
(740K)
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| Computational Biology | Top |
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| Primer |
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What is a support vector machine? pp1565 - 1567
William S Noble
doi:10.1038/nbt1206-1565
Abstract | Full text | PDF
(243K)
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| Brief Communication | Top |
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Blue fluorescent proteins with enhanced brightness and photostability from a structurally targeted library pp1569 - 1571
Marco A Mena, Thomas P Treynor, Stephen L Mayo & Patrick S Daugherty
Published online: 19 November 2006 | doi:10.1038/nbt1264
Abstract | Full text | PDF
(236K)
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| Research | Top |
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| Articles |
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The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT pp1573 - 1580
Chetan Bettegowda, Xin Huang, Jimmy Lin, Ian Cheong, Manu Kohli, Stephen A Szabo, Xiaosong Zhang, Luis A Diaz Jr, Victor E Velculescu, Giovanni Parmigiani, Kenneth W Kinzler, Bert Vogelstein & Shibin Zhou
Published online: 19 November 2006 | doi:10.1038/nbt1256
Abstract | Full text | PDF
(496K)
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See also: News and Views by Forbes |
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An essential role for Akt1 in dendritic cell function and tumor immunotherapy pp1581 - 1590
Dongsu Park, Natalia Lapteva, Mamatha Seethammagari, Kevin M Slawin & David M Spencer
Published online: 03 December 2006 | doi:10.1038/nbt1262
Abstract | Full text | PDF
(562K)
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See also: News and Views by Nestle |
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| Letters |
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Glycan optimization of a human monoclonal antibody in the aquatic plant Lemna minor pp1591 - 1597
Kevin M Cox, Jason D Sterling, Jeffrey T Regan, John R Gasdaska, Karen K Frantz, Charles G Peele, Amelia Black, David Passmore, Cristina Moldovan-Loomis, Mohan Srinivasan, Severino Cuison, Pina M Cardarelli & Lynn F Dickey
Published online: 26 November 2006 | doi:10.1038/nbt1260
Abstract | Full text | PDF
(417K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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Executive compensation at private biotech companies: beyond hearsay pp1599 - 1600
Bruce Rychlik & Mike DiPierro
doi:10.1038/nbt1206-1599
Abstract | Full text | PDF
(115K)
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| People |
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People p1602
doi:10.1038/nbt1206-1602
Full text | PDF
(74K)
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