Nature Biotechnology
- 24, 1541 - 1550 (2006)
Published online: 11 December 2006; | doi:10.1038/nbt1266
New antibiotics from bacterial natural productsJon Clardy, Michael A Fischbach & Christopher T Walsh
Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Correspondence should be addressed to Christopher T Walsh christopher_walsh@hms.harvard.edu For the past five decades, the need for new antibiotics has been met largely by semisynthetic tailoring of natural product scaffolds discovered in the middle of the 20th century. More recently, however, advances in technology have sparked a resurgence in the discovery of natural product antibiotics from bacterial sources. In particular, efforts have refocused on finding new antibiotics from old sources (for example, streptomycetes) and new sources (for example, other actinomycetes, cyanobacteria and uncultured bacteria). This has resulted in several newly discovered antibiotics with unique scaffolds and/or novel mechanisms of action, with the potential to form a basis for new antibiotic classes addressing bacterial targets that are currently underexploited.
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