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Reactions to Eprex's adverse reactions

Nature Biotechnology volume 24, pages 1199–1200 (2006)Cite this article

To the editor:

In their letter of correspondence “Eprex-associated pure red cell aplasia and leachates” in the June issue (Nat. Biotechnol. 24, 613–614, 2006), Schellekens & Jiskoot discuss what they consider to be flaws in Johnson & Johnson's (J&J; New Brunswick, NJ, USA) research on this topic. J&J scientists identified leachates from uncoated stoppers in syringes containing epoetin alfa (Eprex/Erypo) as the most probable cause of the increased incidence of erythropoietin (EPO) antibody-mediated pure red cell aplasia (PRCA) with Eprex, syringes of which were removed from the market in 2003. It is important to note that in their letter, Schellekens & Jiskoot bring no new information to bear on this topic. It also appears that some important publications on this research were not considered in their evaluation of the data.

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References

  1. Sharma, B. et al. Eur. J. Hosp. Pharm. 5, 86–91 (2004).

    Google Scholar 

  2. Ryan, M.H. et al. Int. Immunopharmacol. 6, 647–655 (2006).

    Article  CAS  Google Scholar 

  3. Yano, K., Ohno, S., Nakajima, Y., Toyoshima, S. & Nakajin, S. J. Health Sci. 49, 195–204 (2003).

    Article  CAS  Google Scholar 

  4. Boven, K. et al. Kidney Int. 67, 2346–2353 (2005).

    Article  Google Scholar 

  5. NKF-K/DOQI. Am. J. Kidney Dis. 37 (1 Suppl 1), S182–S238 (2001).

  6. Locatelli, F. et al. Nephrol. Dial. Transplant. 19 Suppl 2, ii1–47 (2004).

    PubMed  Google Scholar 

  7. Rossert, J. et al. Nephrol. Dial. Transplant. 21 Suppl 4, iv153 (2006).

    Google Scholar 

  8. Tredree, R. & Pearce, S. Eur. J. Hosp. Pharm. 1, 11–15 (2003).

    Google Scholar 

  9. Wegewijs, H.W. Eur. J. Hosp. Pharm. 1, 15–17 (2003).

    Google Scholar 

  10. Crommelin, D.J.A., Bissig, M., Gouveia, W. & Tredree, R. Eur. J. Hosp. Pharm. 1, 17–22 (2003).

    Google Scholar 

  11. Boven, K. et al. Nephrol. Dial. Transplant. 20 Suppl 3, iii33–40 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmaceutical Technology, Global Biologics Supply Chain, 1000 Route 202 South, PO Box 300, Raritan, 08869-0602, New Jersey, USA

    Basant Sharma

  2. Biopharmaceutical Research, Centocor Research and Development, Inc., 145 King of Prussia Rd., Radnor, 19087, Pennsylvania, USA

    Mary H. Ryan

  3. Global Clinical Development, Tibotec Inc., 1020 Stony Hill Road, Suite 300, Yardley, 19067, Pennsylvania, USA

    Katia Boven

Authors
  1. Basant Sharma
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  2. Mary H. Ryan
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  3. Katia Boven
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Sharma, B., Ryan, M. & Boven, K. Reactions to Eprex's adverse reactions. Nat Biotechnol 24, 1199–1200 (2006). https://doi.org/10.1038/nbt1006-1199

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