| Drug delivery | | | |
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| Abelcet | Amphotericin B/lipid complex | Fungal infections | Enzon (Bridgewater, NJ, USA) |
| Amphotec | Amphotericin B/lipid colloidal dispersion | Fungal infections | InterMune (Brisbane, CA, USA) |
| Ambisome | Liposomal Amphotericin B | Fungal infections | Gilead (Foster City, CA, USA), Fujisawa (Osaka, Japan) |
| DaunoXome | Liposomal daunorubicin | Kaposi sarcoma | Gilead |
| Doxil/Caelyx | Liposomal doxorubicin | Cancer, Kaposi sarcoma | Ortho Biotech (Bridgewater, NJ, USA); Schering-Plough (Kenilworth, NJ, USA) |
| Depocyt | Liposomal cytarabine | Cancer | SkyePharma (London), Enzon |
| Epaxal Berna | Virosomal hepatitis vaccine | Hepatitis A | Berna Biotech (Bern, Switzerland) |
| Inflexal V Berna | Virosomal influenza vaccine | Influenza | Berna Biotech |
| Myocet | Liposomal doxorubicin | Breast cancer | Zeneus Pharma (Oxford, UK) |
| Visudyne | Liposomal verteporfin | Age-related macular degeneration | QLT (Vancouver, Canada), Novartis (Basel) |
| Estrasorb | Estradiol in micellar nanoparticles | Menopausal therapy | Novavax (Malvern, PA, USA) |
| Adagen | PEG-adenosine deaminase | Immunodeficiency disease | Enzon |
| Neulasta | PEG-G-CSF | Febrile neutropenia | Amgen (Thousand Oaks, CA, USA) |
| Oncaspar | PEG-asparaginase | Leukemia | Enzon |
| Pegasys | PEG- -interferon 2a | Hepatitis C | Nektar (San Carlos, CA, USA), Hoffmann-La Roche (Basel) |
| PEG-Intron | PEG--interferon 2b | Hepatitis C | Enzon, Schering-Plough |
| Macugen | Pegylated anti-VEGF aptamer | Age-related macular degeneration | OSI Pharmaceuticals (Melville, NY, USA), Pfizer (New York) |
| Somavert | PEG-HGH | Acromegaly | Nektar, Pfizer |
| Copaxone | Copolymer of alanine, lysine, glutamic acid and tyrosine | Multiple sclerosis | TEVA Pharmaceuticals (Petach Tikva, Israel) |
| Renagel | Crosslinked poly(allylamine) resin | Chronic kidney disease | Genzyme (Cambridge, MA, USA) |
| Emend | Nanocrystalline aprepitant | Antiemetic | Elan Drug Delivery (King of Prussia, PA, USA), Merck & Co. (Whitehouse Station, NJ, USA) |
| MegaceESc | Nanocrystalline megesterol acetate | Eating disorders | Elan Drug Delivery, Par Pharmaceutical Companies (Woodcliff Lake, NJ, USA) |
| Rapamune | Nanocrystalline sirolimus | Immunosuppressant | Elan Drug Delivery, Wyeth Pharmaceuticals (Collegeville, PA, USA) |
| Tricorc | Nanocrystalline fenofibrate | Lipid regulation | Elan Drug Delivery, Abbott (Abbott Park, IL, USA) |
| Triglidec | Nanocrystalline fenofibrate | Lipid regulation | SkyePharma, First Horizon Pharmaceuticals (Alpharetta, GA, USA) |
| Abraxane | Paclitaxel protein bound nanoparticles | Cancer | Abraxis BioScience (Schaumburg, IL, USA), AstraZeneca (London) |
| In vivo imaging |
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| Resovist | Iron nanoparticles | Liver tumors | Schering (Berlin) |
| Feridex/Endorem | Iron nanoparticles | Liver tumors | Advanced Magnetics (Cambridge, MA, USA), Guerbet (Roissy, France) |
| Gastromark/Lumirem | Iron nanoparticles | Imaging of abdominal structures | Advanced Magnetics, Guerbet |
| In vitro diagnostics |
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| Lateral flow tests | Colloidal gold | Pregnancy, ovulation, HIV, among others | British Biocell (Cardiff, UK), Amersham/GE (Little Chalfont, UK), Nymox (Hasbrouck Heights, NJ, USA) |
| Clinical cell separation | Magnetic nanoparticles | Immunodiagnostics | Dynal/Invitrogen (Oslo, Norway), Miltenyi Biotec (Bergisch Gladbach, Germany), Immunicon (Huntingdon Valley, PA, USA) |
| Biomaterials |
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| Ceram X duo | Nanoparticle composite | Dental filling material | Dentspley (Weybridge, UK) |
| Filtek Supreme | Nanoparticle composite | Dental filling material | 3M Espe (Seefeld, Germany) |
| Mondial | Nanoparticle-containing dental prosthesis | Dental restoration | Heraeus Kulzer (Hanau, Germay) |
| Premise | Nanoparticle composite | Dental repair | Sybron Dental Specialties (Newport Beach, CA, USA) |
| Tetric EvoCeram | Nanoparticle composite | Dental repair | Ivoclar Vivadent (Schaan, Liechtenstein) |
| Ostim | Nano-hydroxyapatite | Bone defects | Osartis (Obernburg, Germany) |
| Perossal | Nano-hydroxyapatite | Bone defects | aap Implantate (Berlin) |
| Vitoss | Nano-hydroxyapatite | Bone defects | Orthovita (Malvern, PA, USA) |
| Acticoat | Silver nanoparticles | Antimicrobial wound care | Nucryst (Wakefield, MA, USA) |
| Active implants |
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| Pacemaker | Fractal electrodes | Heart failure | Biotronik (Berlin) |
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G-CSF, granulocyte colony-stimulating factor; hGH, human growth hormone; PEG, polyethylene glycol; VEGF, vascular endothelial growth factor.
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aDefinitions of nanomedicine products considered in each healthcare sector are provided in Box 1.
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bIn case the product is developed by an alliance, for example, between a drug delivery company and a pharma company, both companies are listed.
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cThese products were not included in the nanomedicine market calculation for 2004, as they entered the market later.
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