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Nature Biotechnology
ISSUE
January 2006, Volume 24 No 1
In This Issue
Editorials
NewsIn Brief | Data Page
BioentrepreneurBioenews | Building a business
Opinion and CommentCorrespondence | Commentary | Investor's Lab | Book Review
FeaturesPatents
News and Views
Computational BiologyPrimer | Analysis
ResearchPerspective | Brief Communications | Article | Letters
NaturejobsCareers and Recruitment | People
About the cover
In This Issue Top
PDF
Editorials Top
Getting beyond Hwang p1
doi:10.1038/nbt0106-1
Full text | PDF (69K)
Genetically modified mush p2
doi:10.1038/nbt0106-2
Full text | PDF (47K)
News Top
Biotech jostles with pharma for slice of HIV market pp3 - 4
Alla Katsnelson
Published online: 05 January 2006 | doi:10.1038/nbt0106-3
Abstract | Full text | PDF (204K)
Serono changes tack p5
Cormac Sheridan
Published online: 05 January 2006 | doi:10.1038/nbt0106-5
Abstract | Full text | PDF (134K)
Shift toward early-stage deals favors biotechs p6
Stacy Lawrence
Published online: 05 January 2006 | doi:10.1038/nbt0106-6
Abstract | Full text | PDF (88K)
Lack of private financing hobbles emerging biotech regions pp7 - 9
Hepeng Jia, K.S. Jayarama & Marina Astvatsaturyan
Published online: 05 January 2006 | doi:10.1038/nbt0106-7
Abstract | Full text | PDF (138K)
In Brief
News In Brief pp11 - 12Published online: 05 January 2006 | 
doi:10.1038/nbt0106-11
Full text | PDF (129K)
Data Page
Tech transfer revs up p13
Stacy Lawrence
Published online: 05 January 2006 | doi:10.1038/nbt0106-13
Full text | PDF (153K)
Bioentrepreneur Top
Bioenews
Swedish roadtrip p15
Stephan Herrera
Published online: 27 October 2005 | doi:10.1038/bioent888
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)

PDF (119K)
Building a business
Beyond patents and royalties: the perception and reality of doing business with the NIH pp17 - 20
Gil Ben-Menachem, Steven M. Ferguson & Krishna Balakrishnan
Published online: 28 December 2005 | doi:10.1038/bioent895
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)

PDF (219K)
Opinion and Comment Top
Correspondence
Wrestling with SUMO and bio-ontologies p21
Mark A. Musen, Suzanna Lewis & Barry Smith
doi:10.1038/nbt0106-21a
Full text | PDF (130K)
Wrestling with SUMO and bio-ontologies pp21 - 22
Christian Stoeckert, Catherine Ball, Alvis Brazma, Ryan Brinkman, Helen Causton, Liju Fan, Jennifer Fostel, Gilberto Fragoso, Mervi Heiskanen, Frank Holstege, Norman Morrison, Helen Parkinson, John Quackenbush, Philippe Rocca-Serra, Susanna-Assunta Sansone, Ugis Sarkans, Gavin Sherlock, Robert Stevens, Chris Taylor, Ronald Taylor, Patricia Whetzel & Joseph White
doi:10.1038/nbt0106-21b
Full text | PDF (140K)
Wrestling with SUMO and bio-ontologies pp22 - 23
Mark Miller & Rami Rifaieh
doi:10.1038/nbt0106-22
Full text | PDF (84K)
Reply to Wrestling with SUMO and bio-ontologies p23
doi:10.1038/nbt0106-23a
Full text | PDF (72K)
European GMO labeling thresholds impractical and unscientific pp23 - 25
Florian Weighardt
doi:10.1038/nbt0106-23b
Full text | PDF (155K)
ATCC not involved in negotiations with India p25
Jesus Soriano
doi:10.1038/nbt0106-25
Full text | PDF (130K)
Commentary
Activism unleashed...and unconscionable pp27 - 28
Henry I Miller
doi:10.1038/nbt0106-27
Abstract | Full text | PDF (315K)
Investor's Lab
Paying over the odds p29
Tom Jacobs
doi:10.1038/nbt0106-29
Full text | PDF (57K)
Book Review
Clone aid p30
Arthur L. Caplan
doi:10.1038/nbt0106-30
Full text | PDF (83K)
Features Top
The licensing of DNA patents by US academic institutions: an empirical survey pp31 - 39
Lori Pressman, Richard Burgess, Robert M Cook-Deegan, Stephen J McCormack, Io Nami-Wolk, Melissa Soucy & LeRoy Walters
doi:10.1038/nbt0106-31
Abstract | Full text | PDF (486K)  | Supplementary Information
Patents
Determining the meaning of claim terms pp41 - 43
Henry E Auer
doi:10.1038/nbt0106-41
Abstract | Full text | PDF (87K)
Recent patent applications in microRNAs p44
doi:10.1038/nbt0106-44
Full text | PDF (38K)
News and Views Top
Fishing for cancer models pp45 - 46
Clemens Grabher & A Thomas Look
doi:10.1038/nbt0106-45
Abstract | Full text | PDF (187K)
See also: Research by Lam et al.
Steroid regulation improves crop yield pp46 - 47
Kenneth A Feldmann
doi:10.1038/nbt0106-46
Abstract | Full text | PDF (113K)
See also: Research by Sakamoto et al.
RNAi tackles a sexually transmitted disease pp48 - 49
Patricia Cristofaro & Bharat Ramratnam
doi:10.1038/nbt0106-48
Abstract | Full text | PDF (120K)
Research Highlights p50
doi:10.1038/nbt0106-50
Full text | PDF (114K)
Computational Biology Top
Primer
Inference in Bayesian networks pp51 - 53
Chris J Needham, James R Bradford, Andrew J Bulpitt & David R Westhead
doi:10.1038/nbt0106-51
Abstract | Full text | PDF (212K)
Analysis
Creation and implications of a phenome-genome network pp55 - 62
Atul J Butte & Isaac S Kohane
Published online: 10 January 2006 | doi:10.1038/nbt1150
Abstract | Full text | PDF (1,674K)  | Supplementary Information
Research Top
Perspective
Transgenic crops expressing Bacillus thuringiensis toxins and biological control pp63 - 71
Jörg Romeis, Michael Meissle & Franz Bigler
Published online: 10 January 2006 | doi:10.1038/nbt1180
Abstract | Full text | PDF (310K)
Brief Communications
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression pp73 - 75
Siew Hong Lam, Yi Lian Wu, Vinsensius B Vega, Lance D Miller, Jan Spitsbergen, Yan Tong, Huiqing Zhan, Kunde R Govindarajan, Serene Lee, Sinnakarupan Mathavan, Karuturi R Krishna Murthy, Donald R Buhler, Edison T Liu & Zhiyuan Gong
Published online: 04 December 2005 | doi:10.1038/nbt1169
Abstract | Full text | PDF (232K)  | Supplementary Information
See also: News and Views by Grabher & Look
Production of a recombinant bacterial lipoprotein in higher plant chloroplasts pp76 - 77
Karin Glenz, Bernadette Bouchon, Thomas Stehle, Reinhard Wallich, Markus M Simon & Heribert Warzecha
Published online: 04 December 2005 | doi:10.1038/nbt1170
Abstract | Full text | PDF (151K)  | Supplementary Information
Article
Engineering and characterization of a superfolder green fluorescent protein pp79 - 88
Jean-Denis Pédelacq, Stéphanie Cabantous, Timothy Tran, Thomas C Terwilliger & Geoffrey S Waldo
Published online: 20 December 2005 | doi:10.1038/nbt1172
Abstract | Full text | PDF (578K)  | Supplementary Information
Letters
A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference pp89 - 94
Selda Samakoglu, Leszek Lisowski, Tulin Budak-Alpdogan, Yelena Usachenko, Santina Acuto, Rosalba Di Marzo, Aurelio Maggio, Ping Zhu, John F. Tisdale, Isabelle Rivière & Michel Sadelain
Published online: 25 December 2005 | doi:10.1038/nbt1176
Abstract | Full text | PDF (303K)  | Supplementary Information
A genetically encoded photosensitizer pp95 - 99
Maria E Bulina, Dmitriy M Chudakov, Olga V Britanova, Yurii G Yanushevich, Dmitry B Staroverov, Tatyana V Chepurnykh, Ekaterina M Merzlyak, Maria A Shkrob, Sergey Lukyanov & Konstantin A Lukyanov
Published online: 20 December 2005 | doi:10.1038/nbt1175
Abstract | Full text | PDF (318K)  | Supplementary Information
Extracellular accumulation of recombinant proteins fused to the carrier protein YebF in Escherichia coli pp100 - 104
Guijin Zhang, Stephen Brokx & Joel H Weiner
Published online: 20 December 2005 | doi:10.1038/nbt1174
Abstract | Full text | PDF (223K)
Erect leaves caused by brassinosteroid deficiency increase biomass production and grain yield in rice pp105 - 109
Tomoaki Sakamoto, Yoichi Morinaka, Toshiyuki Ohnishi, Hidehiko Sunohara, Shozo Fujioka, Miyako Ueguchi-Tanaka, Masaharu Mizutani, Kanzo Sakata, Suguru Takatsuto, Shigeo Yoshida, Hiroshi Tanaka, Hidemi Kitano & Makoto Matsuoka
Published online: 20 December 2005 | doi:10.1038/nbt1173
Abstract | Full text | PDF (311K)  | Supplementary Information
See also: News and Views by Feldmann
Naturejobs Top
Careers and Recruitment
Thinking outside the cell pp111 - 112
Corie Lok
doi:10.1038/nbt0106-111
Abstract | Full text | PDF (67K)
People
People p114
doi:10.1038/nbt0106-114
Full text | PDF (121K)
  Top
 
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Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
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