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Nature Biotechnology 23, 890–895 (1 July 2005) | doi:10.1038/nbt1108

Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes

Ganga Rao Davuluri , Ageeth van Tuinen , Paul D Fraser , Alessandro Manfredonia , Robert Newman , Diane Burgess , David A Brummell , Stephen R King , Joe Palys , John Uhlig , Peter M Bramley , Henk M J Pennings & Chris Bowler

Tomatoes are a principal dietary source of carotenoids and flavonoids, both of which are highly beneficial for human health. Overexpression of genes encoding biosynthetic enzymes or transcription factors have resulted in tomatoes with improved carotenoid or flavonoid content, but never with both.