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| Rapid advances are being made in understanding the mechanisms underlying the plasticity and developmental potential of embryonic and adult human stem cells. While these advances already are influencing the cellular models of human diseases used in traditional drug discovery, ultimately they also promise new treatments for such diseases as Parkinson's, diabetes and heart failure, and brain or spinal injuries, which previously have lacked effective treatments. Nature Biotechnology's Cell Therapies focus examines the scientific, legal, regulatory, and commercial potential of current stem cell research. Art Credit: "The Creation of Organs: Stem Cell Research," oil on canvas
(60x120 in.), Hunter O'Reilly. http://www.hunteroreilly.com |
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| Editorial | Top |
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Focus on Cell Therapies
Proceed with caution p763
doi:10.1038/nbt0705-763
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(83K)
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| News | Top |
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Teva to acquire Chinese biogenerics manufacturer p765
Alla Katsnelson
Published online: 30 June 2005 | doi:10.1038/nbt0705-765
Abstract | Full text | PDF
(113K)
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Politics torpedo biotech as EU priority pp766 - 767
Cormac Sheridan
Published online: 30 June 2005 | doi:10.1038/nbt0705-766
Abstract | Full text | PDF
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China beckons to clinical trial sponsors p768
Hepeng Jia
Published online: 30 June 2005 | doi:10.1038/nbt0705-768
Abstract | Full text | PDF
(127K)
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'Omic diagnostics trip up on way to clinic p769
Malorye A. Branca
Published online: 30 June 2005 | doi:10.1038/nbt0705-769
Abstract | Full text | PDF
(90K)
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| In Brief |
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News In Brief pp771 - 772Published online: 30 June 2005 |
doi:10.1038/nbt0705-771
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Profile: Heinrich Henckel p773
Sabine Louët
Published online: 30 June 2005 | doi:10.1038/nbt0705-773
Abstract | Full text | PDF
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| Data Page |
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State of biotech sector—2004 p774
Stacy Lawrence
Published online: 30 June 2005 | doi:10.1038/nbt0705-774
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(141K)
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| News Feature | Top |
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Focus on Cell Therapies
Leaders and laggards in the stem cell enterprise pp775 - 777
Stephan Herrera
Published online: 30 June 2005 | doi:10.1038/nbt0705-775
Abstract | Full text | PDF
(306K)
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| Bioentrepreneur | Top |
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| Bioenews |
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Early-stage exits: sometimes, less is more p779
George S Mack
Published online: 02 June 2005 | doi:10.1038/bioent865
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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| Building a business |
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Building relationships with technology transfer officers pp781 - 783
O Prem Das
Published online: 23 May 2005 | doi:10.1038/bioent861
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(76K)
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| Opinion and Comment | Top |
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| Correspondence |
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Regulatory regimes for transgenic crops p785
Allison Wilson, Jonathan Latham
& Ricarda Steinbrecher
doi:10.1038/nbt0705-785a
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Regulatory regimes for transgenic crops pp785 - 787
David Schubert
doi:10.1038/nbt0705-785b
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Reply to "Regulatory regimes for transgenic crops" pp787 - 789
Kent J Bradford, Neal Gutterson, Wayne Parrott, Allen Van Deynze
& Steven H Strauss
doi:10.1038/nbt0705-787
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Dual-color, whole-body imaging in mice p790
Robert M. Hoffman
& Meng Yang
doi:10.1038/nbt0705-790
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Reply to "Dual-color, whole-body imaging in mice" p791
doi:10.1038/nbt0705-791a
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Bt toxin not guilty by association p791
Ruud A de Maagd, Alejandra Bravo
& Neil Crickmore
doi:10.1038/nbt0705-791b
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| Commentary |
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Focus on Cell Therapies
Guidelines for human embryonic stem cell research pp793 - 794
Jonathan D Moreno
& Richard O Hynes
doi:10.1038/nbt0705-793
Abstract | Full text | PDF
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Focus on Cell Therapies
The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research pp795 - 797
The Steering Committee of the International Stem Cell Initiative: Peter W Andrews, Nissim Benvenisty, Ron McKay, Martin F Pera, Janet Rossant, Henrik Semb
& Glyn N Stacey
doi:10.1038/nbt0705-795
Abstract | Full text | PDF
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Focus on Cell Therapies
Stem cells—a hard sell to investors pp798 - 800
Lutz B Giebel
doi:10.1038/nbt0705-798
Abstract | Full text | PDF
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Focus on Cell Therapies
Bringing safe and effective cell therapies to the bedside pp801 - 804
Robert A Preti
doi:10.1038/nbt0705-801
Abstract | Full text | PDF
(128K)
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| Investor's Lab |
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When a long shot is worth a shot p805
Tom Jacobs
& Jeff Fischer
doi:10.1038/nbt0705-805
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| Features | Top |
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Focus on Cell Therapies
Chasing a cellular fountain of youth pp807 - 815
Ken Howard Wilan, Christopher Thomas Scott
& Stephan Herrera
doi:10.1038/nbt0705-807
Abstract | Full text | PDF
(289K)
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| Patents |
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Focus on Cell Therapies
The gatekeepers of hES cell products pp817 - 819
Sander Rabin
doi:10.1038/nbt0705-817
Abstract | Full text | PDF
(228K)
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Focus on Cell Therapies
Recent patent applications in cellular therapies p820
doi:10.1038/nbt0705-820
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(38K)
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| News and Views | Top |
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Engineering vascularized tissue pp821 - 823
Rakesh K Jain, Patrick Au, Josh Tam, Dan G Duda
& Dai Fukumura
doi:10.1038/nbt0705-821
Abstract | Full text | PDF
(211K)
See also: Research by Levenberg et al. |
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Biocontrol genome deciphered pp823 - 824
Dieter Haas
doi:10.1038/nbt0705-823
Abstract | Full text | PDF
(149K)
See also: Research by Paulsen et al. |
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A two-for-one in tomato nutritional enhancement pp825 - 826
Richard A Dixon
doi:10.1038/nbt0705-825
Abstract | Full text | PDF
(153K)
See also: Research by Davuluri et al. |
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Customized human embryonic stem cells pp826 - 828
George Q Daley
doi:10.1038/nbt0705-826
Abstract | Full text | PDF
(148K)
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Proteomics takes stem cell analyses to another level pp828 - 830
Andre Levchenko
doi:10.1038/nbt0705-828
Abstract | Full text | PDF
(134K)
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Research Highlights p831
doi:10.1038/nbt0705-831
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| Computational Biology | Top |
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| Commentary |
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Summary recommendations for standardization and reporting of metabolic analyses pp833 - 838
The Standard Metabolic Reporting Structures working group: John C Lindon, Jeremy K Nicholson, Elaine Holmes, Hector C Keun, Andrew Craig, Jake T M Pearce, Stephen J Bruce, Nigel Hardy, Susanna-Assunta Sansone, Henrik Antti, Par Jonsson, Clare Daykin, Mahendra Navarange, Richard D Beger, Elwin R Verheij, Alexander Amberg, Dorrit Baunsgaard, Glenn H Cantor, Lois Lehman-McKeeman, Mark Earll, Svante Wold, Erik Johansson, John N Haselden, Kerstin Kramer, Craig Thomas, Johann Lindberg, Ina Schuppe-Koistinen, Ian D Wilson, Michael D Reily, Donald G Robertson, Hans Senn, Arno Krotzky, Sunil Kochhar, Jonathan Powell, Frans van der Ouderaa, Robert Plumb, Hartmut Schaefer
& Manfred Spraul
doi:10.1038/nbt0705-833
Abstract | Full text | PDF
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| Analysis |
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Effect of sampling on topology predictions of protein-protein interaction networks pp839 - 844
Jing-Dong J Han, Denis Dupuy, Nicolas Bertin, Michael E Cusick
& Marc Vidal
Published online: 07 July 2005 | doi:10.1038/nbt1116
Abstract | Full text | PDF
(532K)
| Supplementary Information |
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| Research | Top |
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| Reviews |
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Focus on Cell Therapies
Regenerating the heart pp845 - 856
Michael A Laflamme
& Charles E Murry
Published online: 07 July 2005 | doi:10.1038/nbt1117
Abstract | Full text | PDF
(886K)
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Focus on Cell Therapies
New sources of pancreatic  -cells pp857 - 861
Susan Bonner-Weir
& Gordon C Weir
Published online: 07 July 2005 | doi:10.1038/nbt1115
Abstract | Full text | PDF
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Focus on Cell Therapies
Stem and progenitor cell−based therapy of the human central nervous system pp862 - 871
Steve Goldman
Published online: 07 July 2005 | doi:10.1038/nbt1119
Abstract | Full text | PDF
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| Article |
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Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5 pp873 - 878
Ian T Paulsen, Caroline M Press, Jacques Ravel, Donald Y Kobayashi, Garry S A Myers, Dmitri V Mavrodi, Robert T DeBoy, Rekha Seshadri, Qinghu Ren, Ramana Madupu, Robert J Dodson, A Scott Durkin, Lauren M Brinkac, Sean C Daugherty, Stephen A Sullivan, Mary J Rosovitz, Michelle L Gwinn, Liwei Zhou, Davd J Schneider, Samuel W Cartinhour, William C Nelson, Janice Weidman, Kisha Watkins, Kevin Tran, Hoda Khouri, Elizabeth A Pierson, Leland S Pierson III, Linda S Thomashow
& Joyce E Loper
Published online: 26 June 2005 | doi:10.1038/nbt1110
Abstract | Full text | PDF
(570K)
| Supplementary Information
See also: News and Views by Haas |
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| Letters |
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Engineering vascularized skeletal muscle tissue pp879 - 884
Shulamit Levenberg, Jeroen Rouwkema, Mara Macdonald, Evan S Garfein, Daniel S Kohane, Diane C Darland, Robert Marini, Clemens A van Blitterswijk, Richard C Mulligan, Patricia A D'Amore
& Robert Langer
Published online: 19 June 2005 | doi:10.1038/nbt1109
Abstract | Full text | PDF
(697K)
| Supplementary Information
See also: News and Views by Jain et al. |
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Multiplexed detection of pathogen DNA with DNA-based fluorescence nanobarcodes pp885 - 889
Yougen Li, Yen Thi Hong Cu
& Dan Luo
Published online: 12 June 2005 | doi:10.1038/nbt1106
Abstract | Full text | PDF
(406K)
| Supplementary Information |
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Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes pp890 - 895
Ganga Rao Davuluri, Ageeth van Tuinen, Paul D Fraser, Alessandro Manfredonia, Robert Newman, Diane Burgess, David A Brummell, Stephen R King, Joe Palys, John Uhlig, Peter M Bramley, Henk M J Pennings
& Chris Bowler
Published online: 12 June 2005 | doi:10.1038/nbt1108
Abstract | Full text | PDF
(310K)
See also: News and Views by Dixon |
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| Errata |
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Erratum: Japan investors shun biotech p896
Ichiko Fuyuno
doi:10.1038/nbt0705-896a
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(70K)
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Erratum: Julian Thurston p896
Sabine Louët
doi:10.1038/nbt0705-896b
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Erratum: Navigating an ethical patchwork—human gene banks p896
Karen J Maschke
doi:10.1038/nbt0705-896c
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(70K)
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Erratum: Biotech hits regulatory doldrums p896
Stacy Lawrence
doi:10.1038/nbt0705-896d
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| Corrigenda |
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Corrigendum: Genetically enhanced cows resist intramammary Staphylococcus aureus infection p897
Robert J Wall, Anne M Powell, Max J Paape, David E Kerr, Douglas D Bannerman, Vernon G Pursel, Kevin D Wells, Neil Talbot
& Harold W Hawk
doi:10.1038/nbt0705-897a
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Corrigendum: Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells p897
Shinsuke Yuasa, Yuji Itabashi, Uichi Koshimizu, Tomofumi Tanaka, Keijiro Sugimura, Masayoshi Kinoshita, Fumiyuki Hattori, Shin-ichi Fukami, Takuya Shimazaki, Hideyuki Okano, Satoshi Ogawa
& Keiichi Fukuda
doi:10.1038/nbt0705-897b
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(47K)
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| Resources | Top |
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| New on the Market |
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Drug discovery p898
doi:10.1038/nbt0705-898a
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(232K)
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Software p898
doi:10.1038/nbt0705-898b
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| Naturejobs | Top |
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| Careers and Recruitment |
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The first 100 days: a biotech CEO survey pp899 - 900
Nicolas Hollanders
doi:10.1038/nbt0705-899
Abstract | Full text | PDF
(116K)
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| People |
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People p902
doi:10.1038/nbt0705-902
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