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Computational Biology
Nature Biotechnology  23, 561 - 566 (2005)
Published online: 5 May 2005; | doi:10.1038/nbt1096

Systematic interpretation of genetic interactions using protein networks

Ryan Kelley & Trey Ideker

Supplementary Fig. 1 (pdf 193K)
Direct overlaps between genetic and physical interactions, while statistically significant, are limited in systematic data and probably biased.

Supplementary Fig. 2 (pdf 180K)
Influence of beta on result set.

Supplementary Fig. 3 (pdf 189K)
Estimated prediction accuracy for naive and pathway-based within-pathway genetic predictions.

Supplementary Table 1 (pdf 20K)
Compounds excluded from the physical interaction network (not used to connect two proteins in a metabolic interaction).

Supplementary Table 2 (pdf 69K)
The members of pathways identified in various searches.

Supplementary Table 3 (pdf 63K)
The log-odds score associated with each network model identified in various searches.

Supplementary Table 4 (pdf 29K)
Results from reduced searches.

Supplementary Table 5 (pdf 24K)
Functional enrichment.

Supplementary Table 6 (pdf 113K)
GO annotation predictions made with pathways obtained from various searches.

Supplementary Table 7 (pdf 22K)
Basis of annotation predictions.


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Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
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