Perspective abstract


Nature Biotechnology 23, 191 - 194 (2005)
Published online: 4 February 2005 | doi:10.1038/nbt1064

Integrating cell-level kinetic modeling into the design of engineered protein therapeutics

Balaji M Rao1, Douglas A Lauffenburger1,2,3 & K Dane Wittrup1,2,3


Functional genomics and proteomics are identifying many potential drug targets for novel therapeutic proteins, and both rational and combinatorial protein engineering methods are available for creating drug candidates. A central challenge is the definition of the most appropriate design criteria, which will benefit critically from computational kinetic models that incorporate integration from the molecular level to the whole systems level. Interpretation of these processes will require mathematical models that are refined in combination with relevant data derived from quantitative assays, to correctly set biophysical objectives for protein design.

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  1. Department of Chemical Engineering, MIT 66-552, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  2. Biological Engineering Division, MIT 66-552, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  3. Biotechnology Process Engineering Center, MIT 66-552, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Correspondence to: K Dane Wittrup1,2,3 e-mail: wittrup@mit.edu



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