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Nature Biotechnology
ISSUE
December 2005, Volume 23 No 12
In This Issue
Editorial
NewsIn Brief | Data Page | News Feature
BioentrepreneurBioenews | Building a business
Opinion and CommentCorrespondence | Commentary | Investor's Lab | Book Review | Patents
News and Views
Computational BiologyPrimer | Analysis | Perspective
ResearchReview | Articles | Letters
ResourcesNew on the Market
NaturejobsCareers and Recruitment | People
About the cover
In This Issue Top
PDF
Editorial Top
Exiting this year and into the next p1451
doi:10.1038/nbt1205-1451
Full text | PDF (67K)
News Top
GlaxoSmithKline cancer drug threatens Herceptin market pp1453 - 1454
Emily Waltz
Published online: 6 December 2005 | doi:10.1038/nbt1205-1453
Abstract | Full text | PDF (92K)
Cord blood cell therapy trial suspended pp1455 - 1456
Cormac Sheridan
Published online: 6 December 2005 | doi:10.1038/nbt1205-1455
Abstract | Full text | PDF (217K)
Cautious industry welcome for US flu vaccine plan pp1457 - 1458
Jim Kling
Published online: 6 December 2005 | doi:10.1038/nbt1205-1457
Abstract | Full text | PDF (234K)
Could bank loans solve Europe's biotech financing slump? pp1459 - 1460
Peter Mitchell
Published online: 6 December 2005 | doi:10.1038/nbt1205-1459
Abstract | Full text | PDF (115K)
In Brief
News In Brief pp1463 - 1464Published online: 6 December 2005 | 
doi:10.1038/nbt1205-1463
Full text | PDF (147K)
Profile: Dmitry Morosov p1465
Sabine Louët
Published online: 6 December 2005 | doi:10.1038/nbt1205-1465
Abstract | Full text | PDF (85K)
Data Page
Biotech drug market steadily expands p1466
Stacy Lawrence
Published online: 6 December 2005 | doi:10.1038/nbt1205-1466
Full text | PDF (140K)
News Feature
Stem cell therapy or snake oil? pp1467 - 1469
Monya Baker
Published online: 6 December 2005 | doi:10.1038/nbt1205-1467
Abstract | Full text | PDF (137K)
Bioentrepreneur Top
Bioenews
China's biotech experiments pp1471 - 1472
Jia Hepeng
Published online: 06 October 2005 | doi:10.1038/bioent884
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)

PDF (142K)
Building a business
Lament of the really crummy deal pp1473 - 1474
Robert MacWright, John Ritter, Pamela L Cox & Jeff Skinner
Published online: 21 November 2005 | doi:10.1038/bioent889
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)

PDF (134K)
Opinion and Comment Top
Correspondence
Reassessing the environmental risks of GM crops pp1475 - 1476
Les Firbank, Mark Lonsdale & Guy Poppy
doi:10.1038/nbt1205-1475
Full text | PDF (113K)
Bollworm resistance to Bt cotton in India pp1476 - 1477
Keshav R. Kranthi
doi:10.1038/nbt1205-1476
Full text | PDF (109K)
Commentary
Should we make a fuss? A case for social responsibility in science pp1479 - 1480
Jon Beckwith & Franklin Huang
doi:10.1038/nbt1205-1479
Abstract | Full text | PDF (100K)
Investor's Lab
Trials and error p1481
Tom Jacobs
doi:10.1038/nbt1205-1481
Full text | PDF (54K)
Book Review
The irrationality precedent p1483
Reviewed by: John Hodgson
doi:10.1038/nbt1205-1483
Full text | PDF (96K)
Patents
Innovation and intellectual property rights in systems biology pp1485 - 1488
Minna Allarakhia & Anthony Wensley
doi:10.1038/nbt1205-1485
Abstract | Full text | PDF (92K)
Recent patent applications in gene expression p1489
doi:10.1038/nbt1205-1489
Full text | PDF (37K)
News and Views Top
A gut feeling pp1491 - 1492
David A F Loebel & Patrick P L Tam
doi:10.1038/nbt1205-1491
Abstract | Full text | PDF (127K)
See also: Research by D'Amour et al.  | Research by Yasunaga et al.
Avimers hold their own pp1493 - 1494
Ki Jun Jeong, Robert Mabry & George Georgiou
doi:10.1038/nbt1205-1493
Abstract | Full text | PDF (178K)
See also: Research by Silverman et al.
Bacterial lessons in sausage making pp1494 - 1495
Vincent G H Eijsink & Lars Axelsson
doi:10.1038/nbt1205-1494
Abstract | Full text | PDF (139K)
See also: Research by Chaillou et al.
Embryonic stem cells without embryos? pp1496 - 1497
Markus Grompe
doi:10.1038/nbt1205-1496
Abstract | Full text | PDF (142K)
Research Highlights p1498
doi:10.1038/nbt1205-1498
Full text | PDF (73K)
Computational Biology Top
Primer
How does gene expression clustering work? pp1499 - 1501
Patrik D'haeseleer
doi:10.1038/nbt1205-1499
Abstract | Full text | PDF (322K)
Analysis
Combined static and dynamic analysis for determining the quality of time-series expression profiles pp1503 - 1508
Itamar Simon, Zahava Siegfried, Jason Ernst & Ziv Bar-Joseph
Published online: 06 December 2005 | doi:10.1038/nbt1164
Abstract | Full text | PDF (426K)  | Supplementary Information
Perspective
Minimum information requested in the annotation of biochemical models (MIRIAM) pp1509 - 1515
Nicolas Le Novère, Andrew Finney, Michael Hucka, Upinder S Bhalla, Fabien Campagne, Julio Collado-Vides, Edmund J Crampin, Matt Halstead, Edda Klipp, Pedro Mendes, Poul Nielsen, Herbert Sauro, Bruce Shapiro, Jacky L Snoep, Hugh D Spence & Barry L Wanner
Published online: 06 December 2005 | doi:10.1038/nbt1156
Abstract | Full text | PDF (212K)
Research Top
Review
Designing dendrimers for biological applications pp1517 - 1526
Cameron C Lee, John A MacKay, Jean M J Fréchet & Francis C Szoka
Published online: 06 December 2005 | doi:10.1038/nbt1171
Abstract | Full text | PDF (730K)  | Supplementary Information
Articles
The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K pp1527 - 1533
Stéphane Chaillou, Marie-Christine Champomier-Vergès, Monique Cornet, Anne-Marie Crutz-Le Coq, Anne-Marie Dudez, Véronique Martin, Sophie Beaufils, Emmanuelle Darbon-Rongère, Robert Bossy, Valentin Loux & Monique Zagorec
Published online: 06 November 2005 | doi:10.1038/nbt1160
Abstract | Full text | PDF (392K)  | Supplementary Information
See also: News and Views by Eijsink & Axelsson
Efficient differentiation of human embryonic stem cells to definitive endoderm pp1534 - 1541
Kevin A D'Amour, Alan D Agulnick, Susan Eliazer, Olivia G Kelly, Evert Kroon & Emmanuel E Baetge
Published online: 28 October 2005 | doi:10.1038/nbt1163
Abstract | Full text | PDF (1,346K)  | Supplementary Information
See also: News and Views by Loebel & Tam
Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells pp1542 - 1550
Masahiro Yasunaga, Shinsuke Tada, Satomi Torikai-Nishikawa, Yoko Nakano, Mitsuhiro Okada, Lars Martin Jakt, Satomi Nishikawa, Tsutomu Chiba, Takumi Era & Shin-Ichi Nishikawa
Published online: 27 November 2005 | doi:10.1038/nbt1167
Abstract | Full text | PDF (559K)  | Supplementary Information
See also: News and Views by Loebel & Tam
Letters
Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana pp1551 - 1555
Ming-Tang Chen & Ron Weiss
Published online: 20 November 2005 | doi:10.1038/nbt1162
Abstract | Full text | PDF (401K)  | Supplementary Information
Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains pp1556 - 1561
Joshua Silverman, Qiang Lu, Alice Bakker, Wayne To, Amy Duguay, Ben M Alba, Richard Smith, Alberto Rivas, Peng Li, Hon Le, Erik Whitehorn, Kevin W Moore, Candace Swimmer, Victor Perlroth, Martin Vogt, Joost Kolkman & Willem Pim C Stemmer
Published online: 20 November 2005 | doi:10.1038/nbt1166
Abstract | Full text | PDF (422K)  | Supplementary Information
See also: News and Views by Jeong et al.
Identification of post-translational modifications by blind search of mass spectra pp1562 - 1567
Dekel Tsur, Stephen Tanner, Ebrahim Zandi, Vineet Bafna & Pavel A Pevzner
Published online: 27 November 2005 | doi:10.1038/nbt1168
Abstract | Full text | PDF (231K)  | Supplementary Information
Resources Top
New on the Market
Expression systems p1568
doi:10.1038/nbt1205-1568
Full text | PDF (144K)
Naturejobs Top
Careers and Recruitment
Managing your compensation expectations in today's environment: a third look pp1569 - 1570
John Radford
doi:10.1038/nbt1205-1569
Abstract | Full text | PDF (99K)
People
People p1572
doi:10.1038/nbt1205-1572
Full text | PDF (77K)
  Top
 
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Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
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