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Volume 23 Issue 10, October 2005

An aggregate of human pancreatic β-cells. The red dye indicates cytoplasmic insulin, and the green dye indicates nuclear Pdx-1. Narushima et al. report a reversible immortalization strategy for generating large numbers of functional human β-cells, (p 1274).

Editorial

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News

  • Chiron's ongoing problems in influenza vaccine production have raised serious questions about the company's future ability to compete in this particular segment of the vaccine market.

    • Cormac Sheridan
    News
  • An important molecule for growth recently received approval in the US. This approval heralds the first medical application of insulin-like growth factor 1 (IGF-1) as a drug to promote growth in a rare group of very small children.

    • Mark Ratner
    News
  • Under the gun of increased oversight on drug company advertising by the US Food and Drug Administration, the Washington, DC-based industry group Pharmaceutical Research and Manufacturers Association (PhRMA) on 29 July announced a set of guiding principles for ethical practices in direct to consumer advertising (DTC).

    • Alla Katsnelson
    News
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News in Brief

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News

  • A hands-off philosophy based on investing in people has served Jean Deleage well over almost 35 years of venture capital investing in the life sciences. He reflects on biotech investment trends.

    • Mark Ratner
    News
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Data Page

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News Feature

  • Deep-sea prospecting is unveiling bizarre species of microbes that already are providing new sources of industrial enzymes, and could be a source of novel therapeutics. Will the lack of treaties governing activities in international waters compromise the commercial potential of the ocean's largesse? Cormac Sheridan investigates.

    • Cormac Sheridan
    News Feature
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Correspondence

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Commentary

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Investors Lab

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Book Review

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Feature

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Patents

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News & Views

  • A reversibly immortalized human β-cell line may find applications in diabetes therapy and drug screening.

    • Hans E Hohmeier
    • Christopher B Newgard
    News & Views
  • An engineered IgG induces degradation of endogenous IgG, providing a potential therapeutic approach to autoimmune disease.

    • Richard S Blumberg
    • Wayne I Lencer
    News & Views
  • The genome sequence of a dechlorinating bacterium offers new opportunities for bioremediation of chlorinated organic pollutants.

    • Rekha Seshadri
    • John Heidelberg
    News & Views
  • A recent meeting emphasized the importance of integrating concepts from developmental biology and other disciplines into tissue engineering.

    • David L Kaplan
    • Randall T Moon
    • Gordana Vunjak-Novakovic
    News & Views
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Commentary

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Analysis

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Review Article

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Article

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Letter

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Corrigendum

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Erratum

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New on the Market

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Careers and Recruitment

  • Reduced side effects and more effective therapies are some of the benefits promised by pharmacogenomics. But to reach these goals, industry will have to marshal a broad range of skills.

    • Ricki Lewis
    Careers and Recruitment
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People

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