Volume 22 Issue 9, September 2004

Editorial

Orphans at the window

Editorial 01 Sept 2004

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News

Cash-strapped biotechs find financing alternative

Publicly quoted biotech companies increasingly rely on private investors to raise money

Peter Mitchell
News 27 Aug 2004
As products enter clinic...scientists shown the door.

Companies are left with fewer resources to do early stage research as their focus shifts when their products enter clinical trials

Mark Ratner
News 27 Aug 2004
Russia becomes attractive as a source of IP for biotechs

Foreign companies in search of original intellectual property strike deals with Russian scientists, encouraged by the imminent accession of Russia to the World Trade Organization

Alla Katsnelson
News 27 Aug 2004
EU to review rare disease drugs market exclusivity

Biotech companies fear that tightening of the orphan drug legislation would remove the main incentive to produce drugs for rare diseases

Cormac Sheridan
News 27 Aug 2004
NAS issues mixed message on unintended effects of GM food

A National Academy of Science report recognizes that genetically modified food may have potentially unanticipated effects.

Jeffrey L. Fox
News 27 Aug 2004
France to focus on a few biotech clusters

As part of its 2005 budget, France's interior minister proposes the creation of two or three biotechnology clusters to attract startups as well as mature companies.

Emilie Balcon
News 27 Aug 2004

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News in Brief

News In Brief

News in Brief 27 Jul 2004

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News

Profile: Jim Greenwood

Stephan Herrera
News 01 Sept 2004

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Data Page

Biotech R&D still reeling

Stacy Lawrence
Data Page 01 Sept 2004

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News Feature

The faking of champions

Surveillance for biotech performance-enhancing drugs was increased at last month's Olympic Games. Will athletes turn to more stealth enhancements in the future? Laura DeFrancesco investigates.

Laura DeFrancesco
News Feature 27 Aug 2004
Coming soon: a global grid for cancer research

The US NCI is spearheading efforts to create a national network for storing cancer tissue samples as well as an international informatics grid to share data. Aaron Bouchie reports.

Aaron Bouchie
News Feature 27 Aug 2004

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Correspondence

Developing market

Wendy Taylor
Correspondence 01 Sept 2004
The $802 million fallacy

John Hodgson
Correspondence 01 Sept 2004
'Informative' horizontal gene transfer

Harry J Gilbert
Anthony G O'Donnell
John C Mathers
Correspondence 01 Sept 2004
Hydrocarbons and renewable energy

Manfred Ringpfeil
Correspondence 01 Sept 2004
AIDS, aneuploidy and oncogenes

Maxwell Gordon
Correspondence 01 Sept 2004
Reply to 'AIDS, aneuploidy and oncogenes'

Correspondence 01 Sept 2004
Reply to 'AIDS, aneuploidy and oncogenes'

Correspondence 01 Sept 2004
Genomic islands in Rhodopseudomonas palustris

Chun-Ting Zhang
Ren Zhang
Correspondence 01 Sept 2004

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Commentary

Keeping dry and crossing membranes

Ariel Fernández
Commentary 01 Sept 2004

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Investors Lab

Does biotech M&A benefit investors?

Tom Jacobs
Investors Lab 01 Sept 2004

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Feature

Goodbye Columbus! New NRDOs forego discovery

Companies that eschew drug discovery in favor of in-licensing have captured a lot of attention and investment over the past few years. But are these young companies really chasing a sustainable business model?

Karl A Thiel
Feature 01 Sept 2004

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News & Views

Phosphoproteomics finds its timing

The temporal dynamics of EGFR signaling has been studied on a broad scale with mass spectrometry.

Sam A Johnson
Tony Hunter
News & Views 01 Sept 2004
β-cell precursors—a work in progress

The adult mouse pancreas contains precursor cells able to differentiate toward both pancreatic and neural lineages.

Gordon C Weir
Susan Bonner-Weir
News & Views 01 Sept 2004
Immunotherapy dispenses with tumor antigens

The induction of CD8⁺ T-cell-mediated immunity against antigens released from normal melanocytes is exploited to destroy metastatic melanomas.

Soldano Ferrone
News & Views 01 Sept 2004
Finding enzymatic gold on silver surfaces

Surface-enhanced resonance Raman scattering enables rapid and sensitive identification of lipase activity and enantioselectivity on dispersed silver nanoparticles.

Uwe T Bornscheuer
News & Views 01 Sept 2004
High-throughput biochemistry heats up

A calorimetric microarray provides a platform for high-throughput thermodynamic measurements for proteomics and drug screening.

F Raymond Salemme
News & Views 01 Sept 2004
Research Highlights

News & Views 01 Sept 2004

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Perspective

Problems in monitoring horizontal gene transfer in field trials of transgenic plants

Jack A Heinemann
Terje Traavik
Perspective 31 Aug 2004
Monitoring and modeling horizontal gene transfer

Kaare M Nielsen
Jeffrey P Townsend
Perspective 31 Aug 2004

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Article

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

Raewyn M Seaberg
Simon R Smukler
Derek van der Kooy
Article 22 Aug 2004
A simple method to cure established tumors by inflammatory killing of normal cells

Gregory A Daniels
Luis Sanchez-Perez
Richard G Vile
Article 01 Aug 2004
Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering

Barry D Moore
Lorna Stevenson
Duncan Graham
Article 08 Aug 2004

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Letter

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics

Blagoy Blagoev
Shao-En Ong
Matthias Mann
Letter 15 Aug 2004
5′-end SAGE for the analysis of transcriptional start sites

Shin-ichi Hashimoto
Yutaka Suzuki
Kouji Matsushima
Letter 08 Aug 2004
Post-integration stabilization of a transposon vector by terminal sequence deletion in Drosophila melanogaster

Alfred M Handler
Grazyna J Zimowska
Carsten Horn
Letter 08 Aug 2004
Evolution of a T7 RNA polymerase variant that transcribes 2′-O-methyl RNA

Jijumon Chelliserrykattil
Andrew D Ellington
Letter 08 Aug 2004
Aggregation-resistant domain antibodies selected on phage by heat denaturation

Laurent Jespers
Oliver Schon
Greg Winter

Collection:

Nobel Prize in Chemistry 2018
Letter 08 Aug 2004

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Patents

The exclusion of diagnostic methods from patentability by the EPC: a case for review?

As prior decisions send mixed signals to practitioners, the European Patent Organization seeks to clarify its stance.

Mathias Ricker
Patents 01 Sept 2004
New Patents

Patents 01 Sept 2004

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People

People

People 01 Sept 2004

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New on the Market

Software & Liquid handling

New on the Market 01 Sept 2004

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Primer

What is Bayesian statistics?

There seem to be a lot of computational biology papers with 'Bayesian' in their titles these days. What's distinctive about 'Bayesian' methods?

Sean R Eddy

Collections:

Statistics for Biologists

Computational Biology
Primer 01 Sept 2004

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Commentary

Funding high-throughput data sharing

Catherine A Ball
Gavin Sherlock
Alvis Brazma
Commentary 01 Sept 2004

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Careers and Recruitment

Strategic HR for today's biotechnology companies

To succeed in the biotechnology industry, human resources must be a true business partner.

Mary Yaroshevsky-Glanville
Careers and Recruitment 01 Sept 2004

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Volume 22 Issue 9, September 2004

Editorial

News

News in Brief

News

Data Page

News Feature

Correspondence

Commentary

Investors Lab

Feature

News & Views

Perspective

Article

Letter

Patents

People

New on the Market

Primer

Commentary

Careers and Recruitment

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