Nature Biotechnology
22, 554 - 559 (2004)
Published online: 11 April 2004; | doi:10.1038/nbt959
The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris HildenboroughJohn F Heidelberg1, 2, Rekha Seshadri1, Shelley A Haveman3, Christopher L Hemme4, Ian T Paulsen1, 5, James F Kolonay1, Jonathan A Eisen1, 5, Naomi Ward1, 2, Barbara Methe1, Lauren M Brinkac1, Sean C Daugherty1, Robert T Deboy1, Robert J Dodson1, A Scott Durkin1, Ramana Madupu1, William C Nelson1, Steven A Sullivan1, Derrick Fouts1, Daniel H Haft1, Jeremy Selengut1, Jeremy D Peterson1, Tanja M Davidsen1, Nikhat Zafar1, Liwei Zhou1, Diana Radune1, George Dimitrov1, Mark Hance1, Kevin Tran1, Hoda Khouri1, John Gill1, Terry R Utterback1, Tamara V Feldblyum1, Judy D Wall4, Gerrit Voordouw3
& Claire M Fraser1, 61
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland
20850, USA. 2
The Center for Marine Biotechnology, 701 East Pratt Street, Baltimore, Maryland
21202, USA. 3
Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, Alberta
T2N 1N4, Canada. 4
Biochemistry Department, University of Missouri-Columbia, 117 Schweitzer Hall, Columbia, Missouri
65211, USA. 5
Johns Hopkins University, Charles and 34th Streets, Baltimore, Maryland
21218, USA. 6
George Washington University Medical Center, 2300 I Street NW, Washington, DC
20037, USA.
Correspondence should be addressed to John F Heidelberg dvu@tigr.org
Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated.
|
