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| Editorial | Top |
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The perils of subsidiarity p1483
doi:10.1038/nbt1204-1483
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(73K)
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| News | Top |
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California votes for embryonic stem cell research pp1485 - 1486
Jeffrey L. Fox
doi:10.1038/nbt1204-1485
Abstract | Full text | PDF
(136K)
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Next generation flu vaccine boosted by Chiron debacle pp1487 - 1488
Cormac Sheridan
doi:10.1038/nbt1204-1487
Abstract | Full text | PDF
(109K)
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IPOs: the narrow window closes? p1489
Stacy Lawrence
doi:10.1038/nbt1204-1489
Abstract | Full text | PDF
(70K)
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FDA and EMEA pool scientific advice pp1490 - 1491
Alla Katsnelson
doi:10.1038/nbt1204-1490
Abstract | Full text | PDF
(104K)
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| In Brief |
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News In Brief pp1493 - 1494
doi:10.1038/nbt1204-1493
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(160K)
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Profile: Daniel Callahan p1495
Stephan Herrera
doi:10.1038/nbt1204-1495
Abstract | Full text | PDF
(38K)
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| Data Page |
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The biotech drug market p1496
Stacy Lawrence
doi:10.1038/nbt1204-1496
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(60K)
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| News Feature |
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Can China bring its own pipeline to the market? pp1497 - 1499
Sabine Louët
doi:10.1038/nbt1204-1497
Abstract | Full text | PDF
(229K)
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| Opinion and Comment | Top |
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| Correspondence |
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No Munich on GM crops p1501
Pierre Malvoisin
& J David Grausz
doi:10.1038/nbt1204-1501a
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(61K)
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Reply to 'No Munich on GM crops' p1501
doi:10.1038/nbt1204-1501b
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(61K)
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Leader sequences are not signal peptides p1502
Michael Mølhøj
& Florence Dal Degan
doi:10.1038/nbt1204-1502
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(228K)
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| Commentary |
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US food safety under siege? pp1503 - 1505
Richard Gilmore
doi:10.1038/nbt1204-1503
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(147K)
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Nuclear transfer cloning and the United Nations pp1506 - 1508
Anthony CF Perry
doi:10.1038/nbt1204-1506
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(250K)
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| Investor's Lab |
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Biotechs for pennies? p1509
Tom Jacobs
doi:10.1038/nbt1204-1509
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(60K)
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| Book Review |
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Biotech basic training p1511
Reviewed by: Aris Persidis
doi:10.1038/nbt1204-1511
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(73K)
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| Feature | Top |
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Recombinant protein therapeutics—success rates, market trends and values to 2010 pp1513 - 1519
Alex K Pavlou
& Janice M Reichert
doi:10.1038/nbt1204-1513
Abstract | Full text | PDF
(307K)
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| News and Views | Top |
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Knocking the SOCS1 off dendritic cells pp1521 - 1522
Eli Gilboa
doi:10.1038/nbt1204-1521
Abstract | Full text | PDF
(107K)
See also: Research by Shen et al. |
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Streptococcal genomes provide food for thought pp1523 - 1524
Hervé Tettelin
doi:10.1038/nbt1204-1523
Abstract | Full text | PDF
(104K)
See also: Research by Bolotin et al. |
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A new harvest of fluorescent proteins pp1524 - 1525
George H Patterson
doi:10.1038/nbt1204-1524
Abstract | Full text | PDF
(113K)
See also: Research by Shaner et al. |
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Putting the opium in poppy to sleep pp1526 - 1527
Johan Memelink
doi:10.1038/nbt1204-1526
Abstract | Full text | PDF
(141K)
See also: Research by Allen et al. |
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Baculovirus solves a complex problem pp1527 - 1528
Polly Roy
doi:10.1038/nbt1204-1527
Abstract | Full text | PDF
(110K)
See also: Research by Berger et al. |
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Uninhibited antibiotic target discovery via chemical genetics pp1528 - 1529
Keith Poole
doi:10.1038/nbt1204-1528
Abstract | Full text | PDF
(117K)
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Research Highlights p1531
doi:10.1038/nbt1204-1531
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(85K)
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| Research | Top |
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| Perspective |
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Antisense and siRNA as agonists of Toll-like receptors pp1533 - 1537
Sudhir Agrawal
& Ekambar R Kandimalla
Published online: 06 December 2004 | doi:10.1038/nbt1042
Abstract | Full text | PDF
(258K)
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| Articles |
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Generation of a synthetic lymphoid tissue−like organoid in mice pp1539 - 1545
Sachiko Suematsu
& Takeshi Watanabe
Published online: 28 November 2004 | doi:10.1038/nbt1039
Abstract | Full text | PDF
(684K)
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Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity pp1546 - 1553
Lei Shen, Kevin Evel-Kabler, Randy Strube
& Si-Yi Chen
Published online: 21 November 2004 | doi:10.1038/nbt1035
Abstract | Full text | PDF
(280K)
| Supplementary Information
See also: News and Views by Gilboa |
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Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus pp1554 - 1558
Alexander Bolotin, Benoît Quinquis, Pierre Renault, Alexei Sorokin, S Dusko Ehrlich, Saulius Kulakauskas, Alla Lapidus, Eugene Goltsman, Michael Mazur, Gordon D Pusch, Michael Fonstein, Ross Overbeek, Nikos Kyprides, Bénédicte Purnelle, Deborah Prozzi, Katrina Ngui, David Masuy, Frédéric Hancy, Sophie Burteau, Marc Boutry, Jean Delcour, André Goffeau
& Pascal Hols
Published online: 14 November 2004 | doi:10.1038/nbt1034
Abstract | Full text | PDF
(205K)
| Supplementary Information
See also: News and Views by Tettelin |
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RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy pp1559 - 1566
Robert S Allen, Anthony G Millgate, Julie A Chitty, Jennifer Thisleton, James A C Miller, Anthony J Fist, Wayne L Gerlach
& Philip J Larkin
Published online: 14 November 2004 | doi:10.1038/nbt1033
Abstract | Full text | PDF
(388K)
| Supplementary Information
See also: News and Views by Memelink |
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| Letters |
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Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein pp1567 - 1572
Nathan C Shaner, Robert E Campbell, Paul A Steinbach, Ben N G Giepmans, Amy E Palmer
& Roger Y Tsien
Published online: 21 November 2004 | doi:10.1038/nbt1037
Abstract | Full text | PDF
(280K)
| Supplementary Information
See also: News and Views by Patterson |
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Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA pp1573 - 1578
Hoshang J Unwalla, Ming-Jie Li, James D Kim, Hai Tang Li, Ali Ehsani, Jessica Alluin
& John J Rossi
Published online: 28 November 2004 | doi:10.1038/nbt1040
Abstract | Full text | PDF
(371K)
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Lack of interferon response in animals to naked siRNAs pp1579 - 1582
Jeremy D Heidel, Siwen Hu, Xian Fang Liu, Timothy J Triche
& Mark E Davis
Published online: 21 November 2004 | doi:10.1038/nbt1038
Abstract | Full text | PDF
(177K)
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Baculovirus expression system for heterologous multiprotein complexes pp1583 - 1587
Imre Berger, Daniel J Fitzgerald
& Timothy J Richmond
Published online: 28 November 2004 | doi:10.1038/nbt1036
Abstract | Full text | PDF
(1,289K)
| Supplementary Information
See also: News and Views by Roy |
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| Errata |
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Erratum: Patent drop reveals pressure on industry p1589
Stacy Lawrence
doi:10.1038/nbt1204-1589a
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(84K)
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Erratum: Cash-strapped biotechs find financing alternative p1589
Peter Mitchell
doi:10.1038/nbt1204-1589b
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(84K)
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| Corrigenda |
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Corrigendum: Engineering sweet targets for magic bullets p1589
Ten Feizi
doi:10.1038/nbt1204-1589c
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(84K)
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Corrigendum: The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens p1589
Soon Ho Hong, Jin Sik Kim, Sang Yup Lee, Yong Ho In, Sun Shim Choi, Jeong-Keun Rih, Chang Hoon Kim, Haeyoung Jeong, Cheol Goo Hur
& Jae Jong Kim
doi:10.1038/nbt1204-1589d
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(84K)
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Corrigendum: Advances in the production of human therapeutic proteins in yeasts and filamentous fungi p1589
Tillman U Gerngross
doi:10.1038/nbt1204-1589e
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Corrigendum: An engineered multidomain bactericidal peptide as a model for targeted antibiotics against specific bacteria p1590
Xiao-Qing Qiu, He Wang, Xiao-Fong Lu, Jie Zhang, Sheng-Fu Li, Gang Cheng, Lin Wan, Li Yang, Jun-Yong Zuo, Yu-Qi Zhou, Hai-Yun Wang, Xin Cheng, Su-Hua Zhang, Zheng-Rong Ou, Zi-Cheng Zhong, Jing-Qiu Cheng, You-Ping Li
& George Y Wu
doi:10.1038/nbt1204-1590a
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(75K)
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| Addendum |
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Addendum: Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide−based retroviral vector p1590
Andrea L Szymczak, Creg J Workman, Yao Wang, Kate M Vignali, Smaroula Dilioglou, Elio F Vanin
& Dario A A Vignali
doi:10.1038/nbt1204-1590b
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(75K)
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| Resources | Top |
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| Patents |
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Intellectual property law in Israel, and US and European objections: Market exclusivity vs. data exclusivity pp1591 - 1592
Tamar Morag-Sela, Ilan Cohn, Thomas J Kowalski, Judy Jarecki-Black
& Zoe Clyde-Watson
doi:10.1038/nbt1204-1591
Abstract | Full text | PDF
(71K)
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New Patents p1593
doi:10.1038/nbt1204-1593
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(41K)
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| People |
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People p1595
doi:10.1038/nbt1204-1595
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(53K)
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| New on the Market |
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Antibodies p1597
doi:10.1038/nbt1204-1597
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(84K)
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Purification p1599
doi:10.1038/nbt1204-1599
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(70K)
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| Computational Biology | Top |
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| Perspective |
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A proposed framework for the description of plant metabolomics experiments and their results pp1601 - 1606
Helen Jenkins, Nigel Hardy, Manfred Beckmann, John Draper, Aileen R Smith, Janet Taylor, Oliver Fiehn, Royston Goodacre, Raoul J Bino, Robert Hall, Joachim Kopka, Geoffrey A Lane, B Markus Lange, Jang R Liu, Pedro Mendes, Basil J Nikolau, Stephen G Oliver, Norman W Paton, Sue Rhee, Ute Roessner-Tunali, Kazuki Saito, Jørn Smedsgaard, Lloyd W Sumner, Trevor Wang, Sean Walsh, Eve Syrkin Wurtele
& Douglas B Kell
Published online: 06 December 2004 | doi:10.1038/nbt1041
Abstract | Full text | PDF
(227K)
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| Bioentrepreneur | Top |
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| Bioenews |
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NIH licensing performance under par pp1607 - 1608
Ken Garber
Published online: 11 November 2004 | doi:10.1038/bioent837
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(117K)
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| Building a business |
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Paths to entrepreneurship in the life sciences pp1609 - 1612
Shreefal Mehta
Published online: 26 October 2004 | doi:10.1038/bioent831
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
PDF
(144K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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What to expect at your biotech job interview p1613
Mary Ann Rafferty
doi:10.1038/nbt1204-1613
Abstract | Full text | PDF
(62K)
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