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Nature Biotechnology 22, 1579–1582 (1 December 2004) | doi:10.1038/nbt1038

Lack of interferon response in animals to naked siRNAs

Jeremy D Heidel , Siwen Hu , Xian Fang Liu , Timothy J Triche & Mark E Davis

RNA interference (RNAi) is rapidly becoming the method of choice for the elucidation of gene function and the identification of drug targets. As with other oligonucleotide-based strategies, RNAi is envisioned to ultimately be useful as a human therapeutic.