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| As more recombinant products gain approval and older products lose patent protection, authors from diverse backgrounds discuss the controversy surrounding biogeneric manufacture and the problems facing the industry in producing follow-on proteins. |
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| Editorial | Top |
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Focus on Biomanufacturing and Bioprocessing
Overdue process p1329
doi:10.1038/nbt1104-1329
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| News | Top |
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Industry wary of NIH consultancy moratorium pp1331 - 1332
Jeffrey L. Fox
doi:10.1038/nbt1104-1331
Abstract | Full text | PDF
(229K)
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Illegal seeds overtake India's cotton fields pp1333 - 1334
K.S. Jayaraman
doi:10.1038/nbt1104-1333
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(185K)
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US NCI launches nanotechnology plan pp1335 - 1336
Joe Alper
doi:10.1038/nbt1104-1335
Abstract | Full text | PDF
(157K)
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Kenyan dispute illuminates bioprospecting difficulties p1337
Cormac Sheridan
doi:10.1038/nbt1104-1337
Abstract | Full text | PDF
(99K)
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| In Brief |
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News In Brief pp1339 - 1340
doi:10.1038/nbt1104-1339
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(133K)
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Focus on Biomanufacturing and Bioprocessing
Profile: Thomas Lönngren p1341
Sabine Louët
doi:10.1038/nbt1104-1341
Abstract | Full text | PDF
(95K)
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| Data Page |
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Biotech in decline in Q3 p1342
Stacy Lawrence
doi:10.1038/nbt1104-1342
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| News Feature |
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Focus on Biomanufacturing and Bioprocessing
Biogenerics standoff pp1343 - 1346
Stephan Herrera
doi:10.1038/nbt1104-1343
Abstract | Full text | PDF
(149K)
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| Opinion and Comment | Top |
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| Correspondence |
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The Cartagena protocol and GMOs pp1347 - 1348
François Pythoud
doi:10.1038/nbt1104-1347
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(109K)
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Ethics, industry and 'animal farm' p1348
Denise Avard
doi:10.1038/nbt1104-1348
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(79K)
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Monitoring horizontal gene transfer p1349
John Davison
doi:10.1038/nbt1104-1349a
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(82K)
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Reply to 'Monitoring horizontal gene transfer' pp1349 - 1350
doi:10.1038/nbt1104-1349b
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Reply to 'Monitoring horizontal gene transfer' p1350
doi:10.1038/nbt1104-1350
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Glycoprotein sialylation in plants? pp1351 - 1352
Martial Séveno, Muriel Bardor, Thomas Paccalet, Véronique Gomord, Patrice Lerouge
& Loïc Faye
doi:10.1038/nbt1104-1351
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(114K)
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Reply to 'Glycoprotein sialylation in plants?' pp1352 - 1353
doi:10.1038/nbt1104-1352
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(103K)
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| Commentary |
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Focus on Biomanufacturing and Bioprocessing
Changes in the business of culture pp1355 - 1356
Pedro de Noronha Pissarra
doi:10.1038/nbt1104-1355
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Focus on Biomanufacturing and Bioprocessing
How similar do 'biosimilars' need to be? pp1357 - 1359
Huub Schellekens
doi:10.1038/nbt1104-1357
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Quantum dots as photosensitizers? pp1360 - 1361
Rumiana Bakalova, Hideki Ohba, Zhivko Zhelev, Mitsuru Ishikawa
& Yoshinobu Baba
doi:10.1038/nbt1104-1360
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| Investor's Lab |
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The best companies bare all p1363
Tom Jacobs
doi:10.1038/nbt1104-1363
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Focus on Biomanufacturing and Bioprocessing
Biomanufacturing, from bust to boom...to bubble? pp1365 - 1372
Karl A Thiel
doi:10.1038/nbt1104-1365
Abstract | Full text | PDF
(195K)
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| News and Views | Top |
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Turning aptamers into anticoagulants pp1373 - 1374
Michael Famulok
doi:10.1038/nbt1104-1373
Abstract | Full text | PDF
(125K)
See also: Research by Rusconi et al. |
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Fluorescent proteins in a new light pp1374 - 1376
Atsushi Miyawaki
doi:10.1038/nbt1104-1374
Abstract | Full text | PDF
(115K)
See also: Research by Chudakov et al. |
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Finding time for allosteric interactions pp1376 - 1377
Irving W Wainer
doi:10.1038/nbt1104-1376
Abstract | Full text | PDF
(108K)
See also: Research by Chen & Hage |
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DNA as a template for reaction discovery pp1378 - 1379
Scott J Miller
doi:10.1038/nbt1104-1378
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(120K)
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Research Highlights p1381
doi:10.1038/nbt1104-1381
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(142K)
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| Research | Top |
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| Perspective |
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Focus on Biomanufacturing and Bioprocessing
Characterizing biological products and assessing comparability following manufacturing changes pp1383 - 1391
Arthur J Chirino
& Anthony Mire-Sluis
Published online: 04 November 2004 | doi:10.1038/nbt1030
Abstract | Full text | PDF
(239K)
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| Reviews |
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Focus on Biomanufacturing and Bioprocessing
Production of recombinant protein therapeutics in cultivated mammalian cells pp1393 - 1398
Florian M Wurm
Published online: 04 November 2004 | doi:10.1038/nbt1026
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Focus on Biomanufacturing and Bioprocessing
Recombinant protein folding and misfolding in Escherichia coli pp1399 - 1408
François Baneyx
& Mirna Mujacic
Published online: 04 November 2004 | doi:10.1038/nbt1029
Abstract | Full text | PDF
(496K)
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Focus on Biomanufacturing and Bioprocessing
Advances in the production of human therapeutic proteins in yeasts and filamentous fungi pp1409 - 1414
Tillman U Gerngross
Published online: 04 November 2004 | doi:10.1038/nbt1028
Abstract | Full text | PDF
(246K)
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Focus on Biomanufacturing and Bioprocessing
Plant cell cultures for the production of recombinant proteins pp1415 - 1422
Stephan Hellwig, Jürgen Drossard, Richard M Twyman
& Rainer Fischer
Published online: 04 November 2004 | doi:10.1038/nbt1027
Abstract | Full text | PDF
(587K)
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| Letters |
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Antidote-mediated control of an anticoagulant aptamer in vivo pp1423 - 1428
Christopher P Rusconi, Joseph D Roberts, George A Pitoc, Shahid M Nimjee, Rebekah R White, George Quick Jr, Elizabeth Scardino, William P Fay
& Bruce A Sullenger
Published online: 17 October 2004 | doi:10.1038/nbt1023
Abstract | Full text | PDF
(237K)
See also: News and Views by Famulok |
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Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity pp1429 - 1434
Ramu A Subbramanian, Chikaya Moriya, Kristi L Martin, Fred W Peyerl, Atsuhiko Hasegawa, Akira Naoi, Heng Chhay, Patrick Autissier, Darci A Gorgone, Michelle A Lifton, Kristine Kuus-Reichel, Jörn E Schmitz, Norman L Letvin
& Marcelo J Kuroda
Published online: 24 October 2004 | doi:10.1038/nbt1024
Abstract | Full text | PDF
(443K)
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Photoswitchable cyan fluorescent protein for protein tracking pp1435 - 1439
Dmitriy M Chudakov, Vladislav V Verkhusha, Dmitry B Staroverov, Ekaterina A Souslova, Sergey Lukyanov
& Konstantin A Lukyanov
Published online: 24 October 2004 | doi:10.1038/nbt1025
Abstract | Full text | PDF
(338K)
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See also: News and Views by Miyawaki |
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Gas-inducible transgene expression in mammalian cells and mice pp1440 - 1444
Wilfried Weber, Markus Rimann, Manuela Spielmann, Bettina Keller, Marie Daoud-El Baba, Dominique Aubel, Cornelia C Weber
& Martin Fussenegger
Published online: 17 October 2004 | doi:10.1038/nbt1021
Abstract | Full text | PDF
(186K)
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Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography pp1445 - 1448
Jianzhong Chen
& David S Hage
Published online: 17 October 2004 | doi:10.1038/nbt1022
Abstract | Full text | PDF
(155K)
| Supplementary Information
See also: News and Views by Wainer |
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| Resources | Top |
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| Patents |
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Publish and perish: what constitutes a bar under the patent laws pp1449 - 1450
Rachel Teitelbaum
& Mark S Cohen
doi:10.1038/nbt1104-1449
Abstract | Full text | PDF
(75K)
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Patents p1451
doi:10.1038/nbt1104-1451
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| People |
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People p1453
doi:10.1038/nbt1104-1453
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| New on the Market |
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Thermocycling and High-throughput screening p1455
doi:10.1038/nbt1104-1455
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(134K)
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| Computational Biology | Top |
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| Primer |
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How do RNA folding algorithms work? pp1457 - 1458
Sean R Eddy
doi:10.1038/nbt1104-1457
Abstract | Full text | PDF
(129K)
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| Perspective |
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A common open representation of mass spectrometry data and its application to proteomics research pp1459 - 1466
Patrick G A Pedrioli, Jimmy K Eng, Robert Hubley, Mathijs Vogelzang, Eric W Deutsch, Brian Raught, Brian Pratt, Erik Nilsson, Ruth H Angeletti, Rolf Apweiler, Kei Cheung, Catherine E Costello, Henning Hermjakob, Sequin Huang, Randall K Julian Jr, Eugene Kapp, Mark E McComb, Stephen G Oliver, Gilbert Omenn, Norman W Paton, Richard Simpson, Richard Smith, Chris F Taylor, Weimin Zhu
& Ruedi Aebersold
Published online: 04 November 2004 | doi:10.1038/nbt1031
Abstract | Full text | PDF
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| Supplementary Information |
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| Analysis |
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Promoter prediction analysis on the whole human genome pp1467 - 1473
Vladimir B Bajic, Sin Lam Tan, Yutaka Suzuki
& Sumio Sugano
Published online: 04 November 2004 | doi:10.1038/nbt1032
Abstract | Full text | PDF
(127K)
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| Bioentrepreneur | Top |
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| Bioenews |
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International regional collaborations are paying off p1475
Peter Mitchell
& Aaron Bouchie
Published online: 30 September 2004 | doi:10.1038/bioent830
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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| Building a business |
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Advice for partnering with pharma pp1477 - 1479
Ken Howard
Published online: 21 September 2004 | doi:10.1038/bioent826
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(81K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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Ask the experts: how to get hired pp1481 - 1482
Grace H W Wong
doi:10.1038/nbt1104-1481
Abstract | Full text | PDF
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