Programs such as MFOLD and ViennaRNA are widely used to predict RNA secondary structures. How do these algorithms work? Why can't they predict RNA pseudoknots? How accurate are they, and will they get better?
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References
Zuker, M. Calculating nucleic acid secondary structure. Curr. Opin. Struct. Biol. 10, 303–310 (2000).
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Eddy, S. How do RNA folding algorithms work?. Nat Biotechnol 22, 1457–1458 (2004). https://doi.org/10.1038/nbt1104-1457
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DOI: https://doi.org/10.1038/nbt1104-1457
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