Nature Biotechnology
22, 1457 - 1458 (2004)
doi:10.1038/nbt1104-1457
How do RNA folding algorithms work?Sean R Eddy
Sean R. Eddy is at Howard Hughes Medical Institute & Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd., Box 8510, Saint Louis, Missouri 63108, USA. eddy@genetics.wustl.edu
Programs such as MFOLD and ViennaRNA are widely used to predict RNA secondary structures. How do these algorithms work? Why can't they predict RNA pseudoknots? How accurate are they, and will they get better?
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