 | Figure 3
Nature Biotechnology
22, 1261 - 1267 (2004)
Published online: 6 October 2004; | doi:10.1038/nbt1016
Exploiting biological complexity for strain improvement through systems biologyGregory Stephanopoulos, Hal Alper
& Joel Moxley | | | | Figure 3. Exploiting complexities in metabolic networks.
Metabolic engineering attempts to exploit the complexities of metabolic networks to improve cellular properties. In this schematic, wild-type cells are engineered to overexpress enzyme E3 with the goal of increasing the low yield of product Y. However, because of network interactions, overexpression of E3 has a minimal effect on the accumulation rates of either products Y or X. To improve the yield of product Y, multiple steps in the network will have to be targeted and genetically modified. In performing these steps, we gain insight into the biological system. Purple circles indicate the pool size of metabolites in the network. Arrow thickness depicts relative flux magnitude of the corresponding reactions.
|
| | | |  |
|
