 | Figure 2
Nature Biotechnology
22, 1282 - 1289 (2004)
Published online: 26 September 2004; | doi:10.1038/nbt1014
Electromechanical integration of cardiomyocytes derived from human embryonic stem cellsIzhak Kehat, Leonid Khimovich, Oren Caspi, Amira Gepstein, Rona Shofti, Gil Arbel, Irit Huber, Jonathan Satin, Joseph Itskovitz-Eldor
& Lior Gepstein | | | | Figure 2. Functional integration in the cocultures.
(a) Phase-contrast micrograph of coculture grown on top of the MEA, showing the hES cardiomyocytes as a white cluster and the rat ventricular myocyte monolayer in black. (b) Left; detailed activation map during spontaneous activity showing the electrical activation originating (red area in the map) in the rat tissue and then propagating to the rest of the coculture, activating also the human tissue. Right; simultaneous recordings from the hES cell−derived (red electrode in Figure 1a) and rat (green electrode) cardiac tissues demonstrating synchronous electrical activity between the two tissue types. (c,d) Activation maps (left) and simultaneous recordings (right) from the rat and human tissues during pacing of either the rat (c) or human (d) tissue.
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