Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focuses
Conferences
Guide to authors
Online submissionOnline submission
Permissions
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
naturereprints
About this site
For librarians
 
NPG Resources
Bioentrepreneur
Nature Reviews Drug Discovery
Nature
Nature Medicine
Nature Genetics
Nature Reviews Genetics
Nature Methods
Nature Chemical Biology
news@nature.com
Clinical Pharmacology & Therapeutics
Nature Conferences
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
Brief Communications
Nature Biotechnology  22, 53 - 54 (2003)
Published online: 7 December 2003; | doi:10.1038/nbt922

Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells

Jonathan S Draper1, 6, Kath Smith2, 6, Paul Gokhale1, Harry D Moore3, Edna Maltby2, Julie Johnson4, Lorraine Meisner4, Thomas P Zwaka5, James A Thomson5 & Peter W Andrews1

1  Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

2  North Trent Clinical Cytogenetics Service, Sheffield Children's Trust, Western Bank, Sheffield S10 2TH, UK.

3  Section of Reproductive and Developmental Medicine, University of Sheffield, Royal Hallamshire Hospital, Jessop Wing, Sheffield S10 2SF, UK.

4  Cytogenetic Laboratory at Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, Wisconsin 53706, USA.

5  National Primate Research Center and the Department of Anatomy, University of Wisconsin−Madison Medical School, 1200 Capital Court, Madison, Wisconsin 53715, USA.

6  These authors contributed equally to this work.

Correspondence should be addressed to Peter W Andrews p.w.andrews@sheffield.ac.uk.
We have observed karyotypic changes involving the gain of chromosome 17q in three independent human embryonic stem (hES) cell lines on five independent occasions. A gain of chromosome 12 was seen occasionally. This implies that increased dosage of chromosome 17q and 12 gene(s) provides a selective advantage for the propagation of undifferentiated hES cells. These observations are instructive for the future application of hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental.


MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

The medium is the message

Nature Biotechnology News and Views (01 Feb 2006)

5Z+55Zyw44Gv44Oh44OD44K744O844K4

Nature Biotechnology News and Views (01 Feb 2006)

See all 7 matches for News And Views
 Top
Abstract
Previous | Next
Table of contents
Full textFull text
Download PDFDownload PDF
Send to a friendSend to a friend

naturejobs

Competing financial interests
Figures & Tables
Supplementary info
See also: News and Views by Pera
Export citation
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | Conferences | For authors | Online submission | Permissions | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | naturereprints | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©2004 Nature Publishing Group | Privacy policy