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| Editorial | Top |
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The quiet revolution p715
doi:10.1038/nbt0703-715
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(53K)
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| News | Top |
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UK biotech sector loses flagship PowderJect to Chiron p717
Pete Mitchell
doi:10.1038/nbt0703-717
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(88K)
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Industry reneges on postmarketing trial commitments p718
Aaron Bouchie
doi:10.1038/nbt0703-718
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(81K)
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European markets target foreign biotechs p719
Sabine Louët
doi:10.1038/nbt0703-719
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(172K)
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Biotech firms jump on SARS bandwagon p720
Paroma Basu
doi:10.1038/nbt0703-720a
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(83K)
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US academia held accountable for GM products pp720 - 721
Kendall Powell
doi:10.1038/nbt0703-720b
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(257K)
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Lawsuits anticipated on generic biologicals front pp721 - 722
Jeffrey L. Fox
doi:10.1038/nbt0703-721
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(260K)
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Sugen falls as casualty of Pfizer−Pharmacia merger pp722 - 723
Ken Garber
doi:10.1038/nbt0703-722
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(256K)
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| In Brief |
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News In Brief pp725 - 727
doi:10.1038/nbt0703-725
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(360K)
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| Opinion and Comment | Top |
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| Correspondence |
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Impact of gene patenting on R&D and commerce pp729 - 731
Mike Stott
& Jill Valentine
doi:10.1038/nbt0703-729
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(212K)
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Reply to "Impact of gene patenting on R&D and commerce" p731
Sandy Thomas
doi:10.1038/nbt0703-731a
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(87K)
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Why RNAi makes sense pp731 - 732
Shelley R. Hough, Kristin A. Wiederholt, Althea C. Burrier, Tod M. Woolf
& Margaret F. Taylor
doi:10.1038/nbt0703-731b
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(260K)
| Supplementary Information |
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Muddied messages about FDA pp732 - 733
Henry I. Miller
doi:10.1038/nbt0703-732
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(337K)
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A TIP on malaria (genomics) p733
Szymon Kaczanowski
& Piotr Zielenkiewicz
doi:10.1038/nbt0703-733
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(165K)
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| Commentary |
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The WTO complaint—why now? pp735 - 736
Julian Kinderlerer
doi:10.1038/nbt0703-735
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(98K)
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First salvo in transatlantic food fight is far from last word pp737 - 738
Henry I Miller
doi:10.1038/nbt0703-737
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(87K)
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Codex guidelines for GM foods include the analysis of unintended
effects pp739 - 741
Alexander G Haslberger
doi:10.1038/nbt0703-739
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(102K)
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Microarray data—the US FDA, industry and academia pp742 - 743
Joseph L. Hackett
& Lawrence J. Lesko
doi:10.1038/nbt0703-742
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(98K)
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Cloned lambs—lessons from pathology pp744 - 745
Susan M Rhind, Tim J King, Linda M Harkness, Chris Bellamy, William Wallace, Paul DeSousa
& Ian Wilmut
doi:10.1038/nbt0703-744
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(97K)
| Supplementary Information |
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| Fool's Corner |
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Another clue to biotech value p746
Tom Jacobs
doi:10.1038/nbt0703-746
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(60K)
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| Feature | Top |
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Economic and regulatory considerations in pharmacogenomics for drug licensing and healthcare pp747 - 753
Jai Shah
doi:10.1038/nbt0703-747
Abstract | Full text | PDF
(149K)
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| News and Views | Top |
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Bone marrow stem cells find a path to the pancreas pp755 - 756
Andreas Lechner
& Joel F Habener
doi:10.1038/nbt0703-755
Abstract | Full text | PDF
(157K)
See also: Research by Hess et al. |
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Vectorology recapitulates virology—will it capitulate
oncology? pp756 - 757
Estaurdo Aguilar-Cordova
doi:10.1038/nbt0703-756
Abstract | Full text | PDF
(338K)
See also: Research by Ahmed et al. |
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Churning out safer microbes for drug delivery pp758 - 759
Michael Syvanen
doi:10.1038/nbt0703-758
Abstract | Full text | PDF
(233K)
See also: Research by Steidler et al. |
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Pointing fingers at the limiting step in gene targeting pp759 - 760
John H Wilson
doi:10.1038/nbt0703-759
Abstract | Full text | PDF
(154K)
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ES cells prove egg-straordinary pp760 - 761
George Q Daley
doi:10.1038/nbt0703-760
Abstract | Full text | PDF
(555K)
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| News and Views |
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Research notes p762
doi:10.1038/nbt0703-762
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(95K)
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| Research | Top |
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| Articles |
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Bone marrow−derived stem cells initiate pancreatic
regeneration pp763 - 770
David Hess, Li Li, Matthew Martin, Seiji Sakano, David Hill, Brenda Strutt, Sandra Thyssen, Douglas A Gray
& Mickie Bhatia
Published online: 22 June 2003 | doi:10.1038/nbt841
Abstract | Full text | PDF
(1,777K)
See also: News and Views by Lechner & Habener |
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A conditionally replicating adenovirus targeted to tumor cells through
activated RAS/P-MAPK-selective mRNA stabilization pp771 - 777
Atique Ahmed, Jill Thompson, Lisa Emiliusen, Stephen Murphy, R Daniel Beauchamp, Kaori Suzuki, Ramon Alemany, Kevin Harrington
& Richard G Vile
Published online: 08 June 2003 | doi:10.1038/nbt835
Abstract | Full text | PDF
(1,851K)
See also: News and Views by Aguilar-Cordova |
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Development of potent monoclonal antibody auristatin conjugates for cancer therapy pp778 - 784
Svetlana O Doronina, Brian E Toki, Michael Y Torgov, Brian A Mendelsohn, Charles G Cerveny, Dana F Chace, Ron L DeBlanc, R Patrick Gearing, Tim D Bovee, Clay B Siegall, Joseph A Francisco, Alan F Wahl, Damon L Meyer
& Peter D Senter
Published online: 01 June 2003 | doi:10.1038/nbt832
Abstract | Full text | PDF
(279K)
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Biological containment of genetically modified Lactococcus
lactis for intestinal delivery of human interleukin 10 pp785 - 789
Lothar Steidler, Sabine Neirynck, Nathalie Huyghebaert, Veerle Snoeck, An Vermeire, Bruno Goddeeris, Eric Cox, Jean Paul Remon
& Erik Remaut
Published online: 15 June 2003 | doi:10.1038/nbt840
Abstract | Full text | PDF
(805K)
See also: News and Views by Syvanen |
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Systematic discovery of analogous enzymes in thiamin
biosynthesis pp790 - 795
Enrique Morett, Jan O Korbel, Emmanuvel Rajan, Gloria Saab-Rincon, Leticia Olvera, Maricela Olvera, Steffen Schmidt, Berend Snel
& Peer Bork
Published online: 08 June 2003 | doi:10.1038/nbt834
Abstract | Full text | PDF
(729K)
| Supplementary Information |
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Engineering a mevalonate pathway in Escherichia coli for
production of terpenoids pp796 - 802
Vincent J J Martin, Douglas J Pitera, Sydnor T Withers, Jack D Newman
& Jay D Keasling
Published online: 01 June 2003 | doi:10.1038/nbt833
Abstract | Full text | PDF
(197K)
| Supplementary Information |
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Noninvasive laser-induced photoacoustic tomography for structural and
functional in vivo imaging of the brain pp803 - 806
Xueding Wang, Yongjiang Pang, Geng Ku, Xueyi Xie, George Stoica
& Lihong V Wang
Published online: 15 June 2003 | doi:10.1038/nbt839
Abstract | Full text | PDF
(956K)
| Supplementary Information |
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Measurement of the millisecond activation switch of G
protein−coupled receptors in living cells pp807 - 812
Jean-Pierre Vilardaga, Moritz Bünemann, Cornelius Krasel, Mariàn Castro
& Martin J Lohse
Published online: 15 June 2003 | doi:10.1038/nbt838
Abstract | Full text | PDF
(419K)
| Supplementary Information |
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| Letters |
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Phosphoinositide profiling in complex lipid mixtures using
electrospray ionization mass spectrometry pp813 - 817
Markus R Wenk, Louise Lucast, Gilbert Di Paolo, Anthony J Romanelli, Sharon F Suchy, Robert L Nussbaum, Gary W Cline, Gerald I Shulman, Walter McMurray
& Pietro De Camilli
Published online: 15 June 2003 | doi:10.1038/nbt837
Abstract | Full text | PDF
(654K)
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A model of molecular interactions on short oligonucleotide
microarrays pp818 - 821
Li Zhang, Michael F Miles
& Kenneth D Aldape
Published online: 08 June 2003 | doi:10.1038/nbt836
Abstract | Full text | PDF
(726K)
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| Corrigenda |
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Identification of anti-repressor elements that confer high
and stable protein production in mammalian cells p822
Ted HJ Kwaks, Phil Barnett, Wieger Hemrika, Tjalling Siersma, Richard GAB Sewalt, David PE Satijn, Janynke F Brons, Rik van Blokland, Paul Kwakman, Arle Kruckeberg, Angèle Kelder
& Arie P Otte
doi:10.1038/nbt0703-822a
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(44K)
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High-throughput engineering of the mouse genome coupled
with high-resolution expression analysis p822
David M Valenzuela, Andrew J Murphy, David Frendewey, Nicholas W Gale, Aris N Economides, Wojtek Auerbach, William T Poueymirou, Niels C Adams, Jose Rojas, Jason Yasenchak, Rostislav Chernomorski, Marylene Boucher, Andrea L Elsasser, Lakeisha Esau, Jenny Zheng, Jennifer Griffiths, Xiaorong Wang, Hong Su, Yingzi Xue, Melissa G Dominguez, Irene Noguera, Richard Torres, Lynn E Macdonald, A Francis Stewart, Thomas M DeChiara
& George D Yancopoulos
doi:10.1038/nbt0703-822b
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(44K)
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| Resources | Top |
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| Patents |
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Inter partes reexamination: a potentially useful approach to challenging invalid biotechnology patents pp823 - 825
Natalie M Derzko
& John W Behringer
doi:10.1038/nbt0703-823
Abstract | Full text | PDF
(83K)
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Recent patents in assay development p826
doi:10.1038/nbt0703-826
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(33K)
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| People |
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People p827
doi:10.1038/nbt0703-827
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(59K)
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| New on the Market |
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Software & Assays p828
doi:10.1038/nbt0703-828
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(293K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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Paring down the company: the effect of consolidation in the European biotech sector pp829 - 830
Peter Bassett
doi:10.1038/nbt0703-831
Abstract | Full text | PDF
(63K)
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