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Nature Biotechnology 21, 652–659 (1 June 2003) | doi:10.1038/nbt822

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

David M Valenzuela , Andrew J Murphy , David Frendewey , Nicholas W Gale , Aris N Economides , Wojtek Auerbach , William T Poueymirou , Niels C Adams , Jose Rojas , Jason Yasenchak , Rostislav Chernomorsky , Marylene Boucher , Andrea L Elsasser , Lakeisha Esau , Jenny Zheng , Jennifer A Griffiths , Xiaorong Wang , Hong Su , Yingzi Xue , Melissa G Dominguez , Irene Noguera , Richard Torres , Lynn E Macdonald , A Francis Stewart , Thomas M DeChiara & George D Yancopoulos