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| Editorial | Top |
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Recipe for disaster p465
doi:10.1038/nbt0503-465
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(52K)
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| Business and Regulatory News | Top |
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| Analysis |
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Concerns over refuge size for US EPA-approved Bt corn pp467 - 468
Kendall Powell
doi:10.1038/nbt0503-467
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(70K)
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Europe sees sharp decline in GMO research pp468 - 469
Peter Mitchell
doi:10.1038/nbt0503-468
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(141K)
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US bioterrorism countermeasures research builds across a broad front pp469 - 470
Jeffrey L. Fox
doi:10.1038/nbt0503-469
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(250K)
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US FDA approves new class of HIV therapeutics pp470 - 471
Debra Robertson
doi:10.1038/nbt0503-470
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(175K)
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| In Brief |
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In Brief pp473 - 475
doi:10.1038/nbt0503-473
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(284K)
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| Opinion | Top |
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| Commentary |
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Thermodynamics—old laws in medicine and complex disease pp477 - 479
Richard Strohman
doi:10.1038/nbt0503-477
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(75K)
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Will we reap what biopharming sows? pp480 - 481
Henry I. Miller
doi:10.1038/nbt0503-480
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(65K)
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The set of embryo subjects pp482 - 483
Louis M. Guenin
doi:10.1038/nbt0503-482
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(71K)
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| Fool's Corner |
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Splurge or merge? p485
Tom Jacobs
doi:10.1038/nbt0503-485
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(52K)
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| Book Review |
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Foretelling our pharmacogenomic future pp487 - 488
Reviewed by: Cheedy Jaja
doi:10.1038/nbt0503-487
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(106K)
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| Correspondence |
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Organelle evolution meets biotechnology pp489 - 490
Chun Y. Huang, Michael A. Ayliffe
& Jeremy N. Timmis
doi:10.1038/nbt0503-489
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(109K)
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Global architecture of genetic interactions on the protein
network pp490 - 491
Owen Ozier, Nada Amin
& Trey Ideker
doi:10.1038/nbt0503-490
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(88K)
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Developing countries and systems biology pp491 - 492
Rafael Rangel-Aldao
doi:10.1038/nbt0503-491
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(221K)
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A genome-wide view of antisense p492
Yoon S. Cho-Chung
& Kevin G. Becker
doi:10.1038/nbt0503-492a
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(207K)
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Delivering zinc fingers pp492 - 493
Joseph Kaminski
& James Bradley Summers
doi:10.1038/nbt0503-492b
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(213K)
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GMO opposition not based on a mistake p493
Jerry Cayford
doi:10.1038/nbt0503-493
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(59K)
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| Features | Top |
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Walking the drug regulatory tightrope pp495 - 498
Alan Dove
doi:10.1038/nbt0503-495
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(175K)
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Biobusiness on the Web pp499 - 503
Robert M. Frederickson
doi:10.1038/nbt0503-499
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(329K)
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| Research News | Top |
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| News and Views |
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The Streptomyces genome—be prepared! pp505 - 506
David A. Hopwood
doi:10.1038/nbt0503-505
Abstract | Full text | PDF
(259K)
See also: Research by Ikeda et al. |
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Engineering what comes naturally pp506 - 508
John M. Wozney
& Rebecca H. Li
doi:10.1038/nbt0503-506
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(178K)
See also: Research by Lutolf et al. |
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Membrane proteins ride shotgun pp508 - 510
Thierry Rabilloud
doi:10.1038/nbt0503-508
Abstract | Full text | PDF
(128K)
See also: Research by Wu et al. |
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The rollercoaster ride to anti-cancer antibodies pp510 - 511
Louis M. Weiner
& Paul Carter
doi:10.1038/nbt0503-510
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(140K)
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| In Brief |
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In Brief p512
doi:10.1038/nbt0503-512
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(90K)
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| Research | Top |
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| Articles |
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Repair of bone defects using synthetic mimetics of collagenous
extracellular matrices pp513 - 518
Matthias P. Lutolf, Franz E. Weber, Hugo G. Schmoekel, Jason C. Schense, Thomas Kohler, Ralph Müller
& Jeffrey A. Hubbell
Published online: 21 April 2003 | doi:10.1038/nbt818
Abstract | Full text | PDF
(1,296K)
See also: Research News by Wozney & Li |
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Modified apoptotic molecule (BID) reduces hepatitis C virus infection
in mice with chimeric human livers pp519 - 525
Eric C. Hsu, Belinda Hsi, Masami Hirota-Tsuchihara, Jurgen Ruland, Cathy Iorio, Farida Sarangi, Jingyu Diao, Giovanni Migliaccio, D. Lorne Tyrrell, Norman Kneteman
& Christopher D. Richardson
Published online: 21 April 2003 | doi:10.1038/nbt817
Abstract | Full text | PDF
(1,036K)
| Supplementary Information |
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Complete genome sequence and comparative analysis of the industrial
microorganism Streptomyces avermitilis pp526 - 531
Haruo Ikeda, Jun Ishikawa, Akiharu Hanamoto, Mayumi Shinose, Hisashi Kikuchi, Tadayoshi Shiba, Yoshiyuki Sakaki, Masahira Hattori
& Satoshi  mura
Published online: 14 April 2003 | doi:10.1038/nbt820
Abstract | Full text | PDF
(298K)
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See also: Research News by Hopwood |
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A method for the comprehensive proteomic analysis of membrane
proteins pp532 - 538
Christine C. Wu, Michael J. MacCoss, Kathryn E. Howell
& John R. Yates III
Published online: 14 April 2003 | doi:10.1038/nbt819
Abstract | Full text | PDF
(1,488K)
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See also: Research News by Rabilloud |
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Simultaneous visualization of multiple protein interactions in living
cells using multicolor fluorescence complementation analysis pp539 - 545
Chang-Deng Hu
& Tom K. Kerppola
Published online: 14 April 2003 | doi:10.1038/nbt816
Abstract | Full text | PDF
(1,187K)
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Site-specific PEGylation of a lysine-deficient TNF- with full
bioactivity pp546 - 552
Yoko Yamamoto, Yasuo Tsutsumi, Yasuo Yoshioka, Toshihide Nishibata, Kyoko Kobayashi, Takayuki Okamoto, Yohei Mukai, Tomoe Shimizu, Shinsaku Nakagawa, Satoshi Nagata
& Tadanori Mayumi
Published online: 31 March 2003 | doi:10.1038/nbt812
Abstract | Full text | PDF
(393K)
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Identification of anti-repressor elements that confer high and stable
protein production in mammalian cells pp553 - 558
Ted H.J. Kwaks, Phil Barnett, Wieger Hemrika, Tjalling Siersma, Richard G.A.B. Sewalt, David P.E. Satijn, Janynke F. Brons, Rik van Blokland, Paul Kwakman, Arle L. Kruckeberg, Angèle Kelder
& Arie P. Otte
Published online: 07 April 2003 | doi:10.1038/nbt814
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(1,054K)
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| Technical Reports |
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Transgenic RNA interference in ES cell−derived embryos
recapitulates a genetic null phenotype pp559 - 561
Tilo Kunath, Gerald Gish, Heiko Lickert, Nina Jones, Tony Pawson
& Janet Rossant
Published online: 07 April 2003 | doi:10.1038/nbt813
Abstract | Full text | PDF
(474K)
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A directional strategy for monitoring Cre-mediated recombination at
the cellular level in the mouse pp562 - 565
Frank Schnütgen, Nathalie Doerflinger, Cécile Calléja, Olivia Wendling, Pierre Chambon
& Norbert B. Ghyselinck
Published online: 31 March 2003 | doi:10.1038/nbt811
Abstract | Full text | PDF
(832K)
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Exploring proteomes and analyzing protein processing by mass
spectrometric identification of sorted N-terminal peptides pp566 - 569
Kris Gevaert, Marc Goethals, Lennart Martens, Jozef Van Damme, An Staes, Grégoire R. Thomas
& Joël Vandekerckhove
Published online: 31 March 2003 | doi:10.1038/nbt810
Abstract | Full text | PDF
(399K)
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Continuous high-titer HIV-1 vector production pp569 - 572
Yasuhiro Ikeda, Yasuhiro Takeuchi, Francisco Martin, Francois-Loic Cosset, Kyriacos Mitrophanous
& Mary Collins
Published online: 07 April 2003 | doi:10.1038/nbt815
Abstract | Full text | PDF
(366K)
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| Resources | Top |
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| Patents |
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Integrating intellectual property within the organizational social
structure pp573 - 575
Iraj Daizadeh
doi:10.1038/nbt0503-573
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(75K)
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Recent patents in protein expression p577
doi:10.1038/nbt0503-577
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(25K)
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| People |
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People p579
doi:10.1038/nbt0503-579
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(88K)
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| New on the Market |
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Cell & tissue culture and Gene & protein expression p581
doi:10.1038/nbt0503-581
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(421K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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The past, present, and future of biotechnology in Mexico pp582 - 583
Lourival D. Possani
doi:10.1038/nbt0503-582
Abstract | Full text | PDF
(208K)
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