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Journal home Advance online publication Current issue Archive Press releases Supplements Focuses Conferences Guide to authors Online submission Permissions For referees Free online issue Contact the journal Subscribe Advertising work@npg naturereprints About this site For librarians   NPG Resources Bioentrepreneur Nature Reviews Drug Discovery Nature Nature Medicine Nature Genetics Nature Reviews Genetics Nature Methods Nature Chemical Biology news@nature.com Clinical Pharmacology & Therapeutics Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Article Nature Biotechnology  21, 513 - 518 (2003) Published online: 21 April 2003; | doi:10.1038/nbt818 Repair of bone defects using synthetic mimetics of collagenous extracellular matrices Matthias P. Lutolf1, 2, Franz E. Weber3, Hugo G. Schmoekel4, Jason C. Schense5, Thomas Kohler1, Ralph Müller1 & Jeffrey A. Hubbell1, 2 1  Institute for Biomedical Engineering, Swiss Federal Institute of Technology, Zurich and University of Zurich, Zurich, Switzerland. 2  Department of Materials Science, Swiss Federal Institute of Technology, Zurich, Zurich, Switzerland. 3  Department of Cranio-Maxillofacial Surgery, University Hospital Zurich, Zurich, Switzerland. 4  Small Animal Surgery, University of Bern, Bern, Switzerland. 5  Straumann, Biologics Division, Waldenburg, Switzerland. Correspondence should be addressed to Jeffrey A. Hubbell hubbell@biomed.mat.ethz.chWe have engineered synthetic poly(ethylene glycol) (PEG)−based hydrogels as cell-ingrowth matrices for in situ bone regeneration. These networks contain a combination of pendant oligopeptide ligands for cell adhesion (RGDSP) and substrates for matrix metalloproteinase (MMP) as linkers between PEG chains. Primary human fibroblasts were shown to migrate within these matrices by integrin- and MMP-dependent mechanisms. Gels used to deliver recombinant human bone morphogenetic protein-2 (rhBMP-2) to the site of critical- sized defects in rat crania were completely infiltrated by cells and were remodeled into bony tissue within five weeks. Bone regeneration was dependent on the proteolytic sensitivity of the matrices and their architecture. The cell-mediated proteolytic invasiveness of the gels and entrapment of rhBMP-2 resulted in efficient and highly localized bone regeneration. You have created an error.  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Novel Approaches to Protecting Maize from Insect Damage Deadline: Jan 31 2010 Reward: $20,000 USD The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re... Methods of Modeling Adaptation in Populations Deadline: Dec 30 2009 Reward: $15,000 USD The analysis of adaptation with a population is a frequently encountered computational modeling scen... More Challenges Powered by: nature jobs Leadership Fellowships University of Oxford Oxford United Kingdom Senior Lecturer / Reader King's College London London United Kingdom More science jobs Post a job for free Competing financial interests Figures & Tables See also: Research News by Wozney & Li Export citation Search buyers guide:   ADVERTISEMENT

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