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| Focus | Top |
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| This focus examines the status of technologies for quantitative protein analysis and the challenges facing efforts to catalogue and characterize the protein content of cells. |
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| Editorial | Top |
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Challenges in Proteomics
A cast of thousands p213
doi:10.1038/nbt0303-213
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(51K)
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| Business and Regulatory News | Top |
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| Analysis |
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UK industry consolidation is slow despite big merger p215
Peter Mitchell
doi:10.1038/nbt0303-215
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(587K)
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US budget/Bioshield initiative emphasizes bioterrorism countermeasures p216
Jeffrey L. Fox
doi:10.1038/nbt0303-216
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(58K)
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US authorities uphold suspension of SCID gene therapy p217
Jeffrey L. Fox
doi:10.1038/nbt0303-217
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(460K)
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Japan launches new life-science initiatives p218
Robert Triendl
doi:10.1038/nbt0303-218
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(57K)
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| In Brief |
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In Brief pp219 - 220
doi:10.1038/nbt0303-219
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(175K)
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| Opinion | Top |
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| Commentary |
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Challenges in Proteomics
Data analysis—the Achilles heel of proteomics pp221 - 222
Scott D. Patterson
doi:10.1038/nbt0303-221
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(55K)
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Challenges in Proteomics
Recombinant antibody microarrays—a viable option? p223
Christer Wingren, Johan Ingvarsson, Malin Lindstedt
& Carl A.K. Borrebaeck
doi:10.1038/nbt0303-223
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(383K)
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Encoding technical information in GM organisms pp224 - 226
Sylvestre Marillonnet, Victor Klimyuk
& Yuri Gleba
doi:10.1038/nbt0303-224
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Transgenic organisms—time for conceptual diversification? pp227 - 228
Kaare M. Nielsen
doi:10.1038/nbt0303-227
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(55K)
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| Correspondence |
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Why reinvent risk? p229
Robert C. Lee
doi:10.1038/nbt0303-229a
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(54K)
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Telomere-driven replicative senescence is a stress response pp229 - 230
Thomas von Zglinicki, Joanne Petrie
& Thomas B.L. Kirkwood
doi:10.1038/nbt0303-229b
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(263K)
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Choosing CCR5 or Rev siRNA in HIV-1 pp230 - 231
H. Jose Arteaga, Jorma Hinkula, Iris van Dijk-Härd, M. Sirac Dilber, Britta Wahren, Birger Christensson, Abdalla J. Mohamed
& C. I. Edvard Smith
doi:10.1038/nbt0303-230
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(445K)
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| Feature | Top |
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Challenges in Proteomics
In the pursuit of industrial proteomics pp233 - 237
Peter Mitchell
doi:10.1038/nbt0303-233
Abstract | Full text | PDF
(1,352K)
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| Research News | Top |
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| News and Views |
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'Omics' of the mitochondrion pp239 - 240
Benedikt Westermann
& Walter Neupert
doi:10.1038/nbt0303-239
Abstract | Full text | PDF
(261K)
See also: Research by Taylor et al. | Research by Ozawa et al. |
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Bringing diabetes therapeutics to the big screen pp240 - 241
Leif Groop
doi:10.1038/nbt0303-240
Abstract | Full text | PDF
(103K)
See also: Research by Chen et al. |
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Fingers reach for the genome pp242 - 243
Aseem Z. Ansari
doi:10.1038/nbt0303-242
Abstract | Full text | PDF
(269K)
See also: Research by Blancafort et al. | Research by Bae et al. |
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Harnessing microbial appetites for remediation pp243 - 244
Kenneth H. Nealson
doi:10.1038/nbt0303-243
Abstract | Full text | PDF
(310K)
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| In Brief |
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In Brief p245
doi:10.1038/nbt0303-245
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(393K)
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| Research | Top |
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| Perspective |
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Challenges in Proteomics
A systematic approach to modeling, capturing, and disseminating
proteomics experimental data pp247 - 254
Chris F. Taylor, Norman W. Paton, Kevin L. Garwood, Paul D. Kirby, David A. Stead, Zhikang Yin, Eric W. Deutsch, Laura Selway, Janet Walker, Isabel Riba-Garcia, Shabaz Mohammed, Michael J. Deery, Julie A. Howard, Tom Dunkley, Ruedi Aebersold, Douglas B. Kell, Kathryn S. Lilley, Peter Roepstorff, John R. Yates III, Andy Brass, Alistair J.P. Brown, Phil Cash, Simon J. Gaskell, Simon J. Hubbard
& Stephen G. Oliver
doi:10.1038/nbt0303-247
Abstract | Full text | PDF
(3,149K)
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| Reviews |
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Challenges in Proteomics
Proteomic analysis of post-translational modifications pp255 - 261
Matthias Mann
& Ole N. Jensen
doi:10.1038/nbt0303-255
Abstract | Full text | PDF
(506K)
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Challenges in Proteomics
The application of mass spectrometry to membrane proteomics pp262 - 267
Christine C. Wu
& John R. Yates III
doi:10.1038/nbt0303-262
Abstract | Full text | PDF
(394K)
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| Articles |
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Scanning the human genome with combinatorial transcription factor
libraries pp269 - 274
Pilar Blancafort, Laurent Magnenat
& Carlos F. Barbas III
Published online: 18 February 2003 | doi:10.1038/nbt794
Abstract | Full text | PDF
(3,088K)
| Supplementary Information
See also: Research News by Ansari |
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Human zinc fingers as building blocks in the construction of
artificial transcription factors pp275 - 280
Kwang-Hee Bae, Young Do Kwon, Hyun-Chul Shin, Moon-Sun Hwang, Eun-Hyun Ryu, Kyung-Soon Park, Hyo-Young Yang, Dong-ki Lee, Yangsoon Lee, Jinwoo Park, Heung Sun Kwon, Hyun-Won Kim, Byung-Il Yeh, Hyean-Woo Lee, Soon Hyung Sohn, Joonho Yoon, Wongi Seol
& Jin-Soo Kim
Published online: 18 February 2003 | doi:10.1038/nbt796
Abstract | Full text | PDF
(2,065K)
| Supplementary Information
See also: Research News by Ansari |
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Characterization of the human heart mitochondrial proteome pp281 - 286
Steven W. Taylor, Eoin Fahy, Bing Zhang, Gary M. Glenn, Dale E. Warnock, Sandra Wiley, Anne N. Murphy, Sara P. Gaucher, Roderick A. Capaldi, Bradford W. Gibson
& Soumitra S. Ghosh
Published online: 18 February 2003 | doi:10.1038/nbt793
Abstract | Full text | PDF
(1,840K)
| Supplementary Information
See also: Research News by Westermann & Neupert |
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A genetic approach to identifying mitochondrial proteins pp287 - 293
Takeaki Ozawa, Yusuke Sako, Moritoshi Sato, Toshio Kitamura
& Yoshio Umezawa
Published online: 10 February 2003 | doi:10.1038/nbt791
Abstract | Full text | PDF
(2,730K)
| Supplementary Information
See also: Research News by Westermann & Neupert |
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An integrated functional genomics screening program reveals a role for
BMP-9 in glucose homeostasis pp294 - 301
Cecil Chen, Krzysztof J. Grzegorzewski, Steve Barash, Qinghai Zhao, Helmut Schneider, Qi Wang, Mallika Singh, Laurie Pukac, Adam C. Bell, Roxanne Duan, Tim Coleman, Alokesh Duttaroy, Susan Cheng, Jon Hirsch, Linyi Zhang, Yanick Lazard, Carrie Fischer, Melisa Carey Barber, Zhi-Dong Ma, Ya-Qin Zhang, Peter Reavey, Lilin Zhong, Baiqin Teng, Indra Sanyal, Steve M. Ruben, Olivier Blondel
& Charles E. Birse
Published online: 24 February 2003 | doi:10.1038/nbt795
Abstract | Full text | PDF
(2,269K)
| Supplementary Information
See also: Research News by Groop |
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TIP, a T-cell factor identified using high-throughput screening
increases survival in a graft-versus-host disease model pp302 - 307
Michele Fiscella, James W. Perry, Baiqin Teng, Michael Bloom, Chen Zhang, Kam Leung, Laurie Pukac, Kimberly Florence, Alice Concepcion, Binjun Liu, Ying Meng, Cecil Chen, Erika Cochrane Elgin, Palanisamy Kanakaraj, Thomas E. Kaufmann, Joelle Porter, Ricardo Cibotti, Yun Mei, Joe Zhou, Guoxian Chen, Viktor Roschke, George Komatsoulis, Brian Mansfield, Steve Ruben, Indra Sanyal
& Thi-Sau Migone
Published online: 24 February 2003 | doi:10.1038/nbt797
Abstract | Full text | PDF
(1,567K)
| Supplementary Information |
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In situ assembly of enzyme inhibitors using extended tethering pp308 - 314
Daniel A. Erlanson, Joni W. Lam, Christian Wiesmann, Tinh N. Luong, Robert L. Simmons, Warren L. DeLano, Ingrid C. Choong, Matthew T. Burdett, W. Michael Flanagan, Dennis Lee, Eric M. Gordon
& Tom O'Brien
Published online: 03 February 2003 | doi:10.1038/nbt786
PDB code 1NME | 1NMQ | 1NMS
Abstract | Full text | PDF
(1,254K)
| Supplementary Information |
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| Technical Reports |
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A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling pp315 - 318
Blagoy Blagoev, Irina Kratchmarova, Shao-En Ong, Mogens Nielsen, Leonard J. Foster
& Matthias Mann
Published online: 10 February 2003 | doi:10.1038/nbt790
Abstract | Full text | PDF
(1,054K)
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Homologous recombination in human embryonic stem cells pp319 - 321
Thomas P. Zwaka
& James A. Thomson
Published online: 10 February 2003 | doi:10.1038/nbt788
Abstract | Full text | PDF
(1,052K)
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Site-specific cassette exchange and germline transmission with mouse ES cells expressing  C31 integrase pp321 - 324
Gusztav Belteki, Marina Gertsenstein, David W. Ow
& Andras Nagy
Published online: 03 February 2003 | doi:10.1038/nbt787
Abstract | Full text | PDF
(527K)
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Recombinant Dicer efficiently converts large dsRNAs into siRNAs
suitable for gene silencing pp324 - 328
Jason W. Myers, Joshua T. Jones, Tobias Meyer
& James E. Ferrell Jr.
Published online: 18 February 2003 | doi:10.1038/nbt792
Abstract | Full text | PDF
(1,687K)
| Supplementary Information |
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| Resources | Top |
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| Patents |
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Equivalents in biotechnology patents pp329 - 331
Henry E. Auer
doi:10.1038/nbt0303-329
Abstract | Full text | PDF
(66K)
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Recent patents in microfluidics p333
doi:10.1038/nbt0303-333
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(26K)
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| People |
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People p335
doi:10.1038/nbt0303-335
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(124K)
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| New on the Market |
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Genomics & proteomics p337
doi:10.1038/nbt0303-337
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(1,533K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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Bioveterinary science: development of a discipline pp339 - 340
Iain Young
doi:10.1038/nbt0303-339
Abstract | Full text | PDF
(53K)
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