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Nature Biotechnology 21, 1509–1512 (1 December 2003) | doi:10.1038/nbt910

Analyzing antibody specificity with whole proteome microarrays

Gregory A Michaud , Michael Salcius , Fang Zhou , Rhonda Bangham , Jaclyn Bonin , Hong Guo , Michael Snyder , Paul F Predki & Barry I Schweitzer

Although approximately 10,000 antibodies are available from commercial sources, antibody reagents are still unavailable for most proteins. Furthermore, new applications such as antibody arrays and monoclonal antibody therapeutics have increased the demand for more specific antibodies to reduce cross-reactivity and side effects.