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Research
Nature Biotechnology 21, 1499–1504 (1 December 2003) | doi:10.1038/nbt908
An archaeal endoribonuclease catalyzes cis- and trans- nonspliceosomal splicing in mouse cells
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Abstract
The tRNA endonuclease from the archaebacterium Methanococcus jannaschii (MJ endonuclease) can cleave RNAs forming specific bulge-helix-bulge (BHB) structures recognized by the enzyme. The resulting cleavage products are subsequently joined together by an endogenous ligase.
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