Nature Biotechnology

Volume 21 Issue 11, November 2003

3D image of the mitochondrial compartment of a live yeast cell obtained through volume rendering of a superresolution 3D data stack recorded with a 4Pi microscope. Courtesy of H. Gugel, R. Storz (Leica Microsystems Heidelberg GmbH, Mannheim, Germany) and J. Bewersdorf, S. Jakobs, J. Engelhardt, S.W. Hell (MPI for Biophysical Chemistry, Göttingen, Germany). The 3D image is superimposed on a colored high resolution scanning electron micrograph of mitochondria and rough endoplasmic reticulum. © PhotoResearchers. Artwork rendered by Erin Boyle.

Volume 21 Issue 11

Editorial

Out of the shadows

Editorial 01 Nov 2003

Advertisement

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News

US NHGRI launches chemical attack on drug development gap

Ken Garber
News 01 Nov 2003
Public–private partnerships boost research on neglected diseases

Sabine Louët
News 01 Nov 2003
Concerns raised over declining antiinfectives R&D

Jeffrey L. Fox
News 01 Nov 2003
Japan's biotech sector shows signs of life

Keiko Kandachi
News 01 Nov 2003
GM confusion in Brazil

Ricardo Bonalume Neto
News 01 Nov 2003
Benefits of biotech clusters questioned

Cormac Sheridan
News 01 Nov 2003
Biotech parks proliferate, despite concerns over sustainability

Hepeng Jia
News 01 Nov 2003

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News in Brief

News In Brief

News in Brief 01 Nov 2003

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Correspondence

Letter 1: Equivocal role of micelles in Eprex adverse events

Janice M Smiell
Correspondence 01 Nov 2003
Letter 2: Equivocal role of micelles in Eprex adverse events

Huub Schellekens
Daan J A Crommelin
Correspondence 01 Nov 2003
Reply to: Equivocal role of micelles in Eprex adverse events

Correspondence 01 Nov 2003
Chaperonins govern growth of Escherichia coli at low temperatures

Manuel Ferrer
Tatyana N Chernikova
Kenneth N Timmis
Correspondence 01 Nov 2003
Chaperonins govern growth of Escherichia coli at low temperatures

Manuel Ferrer
Tatyana N Chernikova
Kenneth N Timmis
Correspondence 01 Nov 2003

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Commentary

Invention and commercialization in optical bioimaging

Daniel L Farkas
Commentary 01 Nov 2003
Crystal gazing in optical microscopy

Scott E Fraser
Commentary 01 Nov 2003
A framework for designing transgenic crops—science, safety and citizen's concerns

Ariane König
Commentary 01 Nov 2003
Gene medication or genetic modification? The devil is in the details

Grethe S Foss
Sissel Rogne
Commentary 01 Nov 2003
The tyranny of 'genethics'

Leigh Turner
Commentary 01 Nov 2003

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Fools Corner

Why biotech don't pay dividends — yet

Tom Jacobs
Fools Corner 01 Nov 2003

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Book Review

How to sell an industry

Donna Murray
Book Review 01 Nov 2003

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Feature

The rise of European venture capital for biotechnology

Changes in economic institutions and the entrepreneurial climate, together with a growth in venture capital funds, have greatly increased European biotechnology venture formation in recent years.

Michael Howell
Melanie Trull
Mark D Dibner
Feature 01 Nov 2003

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News & Views

Engineering better cytokines

Designing enzymes with protective shells that are cleaved once they arrive at inflammatory sites can be used to enhance immune therapy.

Lawrence Steinman
News & Views 01 Nov 2003
Sequence of a symbiont

The complete genome sequence of the insect pathogen and nematode symbiont Photorhabdus luminescens identifies a trove of antibiotic and toxin genes.

Valerie M Williamson
Harry K Kaya
News & Views 01 Nov 2003
Reconstructing genetic networks in yeast

By combining data from gene expression and DNA-binding experiments, a computational algorithm identifies the genetic regulatory network in yeast.

Zhaolei Zhang
Mark Gerstein
News & Views 01 Nov 2003
Playing tag with the yeast proteome

Two tagged proteome studies offer the most intimate and detailed view into the inner works of yeast cells to date.

Brenda J Andrews
Gary D Bader
Charles Boone
News & Views 01 Nov 2003
Research notes

News & Views 01 Nov 2003

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Brief Communication

Immunofluorescence stimulated emission depletion microscopy

Marcus Dyba
Stefan Jakobs
Stefan W Hell
Brief Communication 19 Oct 2003
Human antibodies from immunized donors are protective against anthrax toxin in vivo

Martha A Wild
Hong Xin
Katherine S Bowdish
Brief Communication 12 Oct 2003

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Article

The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens

Eric Duchaud
Christophe Rusniok
Frank Kunst
Article Open Access 05 Oct 2003
Targeting cytokines to inflammation sites

Gill Adams
Sandrine Vessillier
Yuti Chernajovsky
Article 05 Oct 2003
A genetic approach to inactivating chemokine receptors using a modified viral protein

V McNeil Coffield
Qi Jiang
Lishan Su
Article 12 Oct 2003
E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models

Yaohe Wang
Gunnel Hallden
David Kirn
Article 12 Oct 2003

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Letter

Computational discovery of gene modules and regulatory networks

Ziv Bar-Joseph
Georg K Gerber
David K Gifford
Letter 12 Oct 2003
Enzymatic synthesis of antithrombin III–binding heparan sulfate pentasaccharide

Balagurunathan Kuberan
Miroslaw Z Lech
Robert D Rosenberg
Letter 05 Oct 2003

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Perspective

Toward fluorescence nanoscopy

Stefan W Hell
Perspective 31 Oct 2003
Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms

Paul J Campagnola
Leslie M Loew
Perspective 31 Oct 2003
Optical coherence tomography for ultrahigh resolution in vivo imaging

James G Fujimoto
Perspective 31 Oct 2003

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Review Article

Nonlinear magic: multiphoton microscopy in the biosciences

Warren R Zipfel
Rebecca M Williams
Watt W Webb
Review Article 31 Oct 2003
Near-field optics: from subwavelength illumination to nanometric shadowing

Aaron Lewis
Hesham Taha
Erich Ammann
Review Article 31 Oct 2003
FRET imaging

Elizabeth A Jares-Erijman
Thomas M Jovin
Review Article 31 Oct 2003

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Erratum

Erratum: Biopharmaceutical benchmarks—2003

Gary Walsh
Erratum 01 Nov 2003

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Corrigendum

Erratum: Phosphospecific proteolysis for mapping sites of protein phosphorylation

Zachary A Knight
Birgit Schilling
Kevan M Shokat
Corrigendum 01 Nov 2003

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Patents

Past versus present: the importance of tense in patent application examples

The Federal Circuit questions an example's validity in Hoffmann-La Roche, Inc. v. Promega.

Jane E R Potter
Gargi Talukder
Patents 01 Nov 2003
Recent patent applications in gene expression

Patents 01 Nov 2003

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People

People

People 01 Nov 2003

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New on the Market

Imaging & microscopy

New on the Market 01 Nov 2003

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Careers and Recruitment

Professional master's degree programs in regulatory affairs and biomedical quality systems

Two new programs are designed to supply biotechnology professionals with industry-specific skills required for successful biomedical product development.

E Dale Sevier
Robert Wang
A Stephen Dahms
Careers and Recruitment 01 Nov 2003

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Focus

Optical imaging

Brings together a selection of articles on new techniques in optical imaging.

Focus 01 Nov 2003

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