Nature Biotechnology
20, 666 - 668 (2002)
doi:10.1038/nbt0702-666
Metabolic engineering by genome shufflingGregory Stephanopoulos
Gregory Stephanopoulos is Bayer Professor of
Chemical Engineering and Biotechnology, Department of Chemical
Engineering, Massachusetts Institute of Technology, 77
Massachusetts Avenue, Room 56-469, Cambridge, MA
02319 gregstep@mit.edu. Two reports on whole-genome shuffling demonstrate the application
of combinatorial methods for phenotypic improvement in bacteria.
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