Selectable marker genes are required to ensure the efficient
genetic modification of crops. Economic incentives and safety concerns have
prompted the development of several strategies (site-specific recombination,
homologous recombination, transposition, and co-transformation) to eliminate
these genes from the genome after they have fulfilled their purpose. Recently,
chemically inducible site-specific recombinase systems have emerged as valuable
tools for efficiently regulating the excision of transgenes when their
expression is no longer required. The implementation of these strategies in
crops and their further improvement will help to expedite widespread public
acceptance of agricultural biotechnology
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