Derek S. Tan is head of the Laboratory of Chemistry & Chemical Genetics and an assistant member at the Memorial Sloan−Kettering Cancer Center, 1275 York Ave., RRL-1317, Box 422, New York, NY 10021 tand@mskcc.org.
Small molecules can extend the resolution of functional genomics beyond gene knockouts, allowing specific functions of a multifunctional protein to be modulated selectively.
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