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Volume 20 Issue 3, March 2002

Joy, one of five cloned knockout piglets produced by Dai et.al. (p. 251). The gene inactivated in these pigs, α 1,3 galactosyl transferase, synthesizes an antigen involved in the immune rejection of pig to human transplants.

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  • Proteins, not genes, are the true targets of medicines, but their analysis by array technology still poses significant challenges for drug developers.

    • Peter Mitchell
    Feature
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News & Views

  • Two reports on the knockout of one allele of the α1,3-galactosyltransferase gene in pigs bring us one step closer to the transplantation of pig organs into people.

    • Jeffrey L. Platt
    News & Views
  • Peptide chips enable quantitative analysis of protein kinase activity and should facilitate the search for novel classes of protein kinase inhibitors.

    • Joseph Schlessinger
    News & Views
  • A method for producing large carbohydrate microarrays allows high-throughput, sensitive detection of carbohydrate–antibody interactions.

    • Laura L. Kiessling
    • Christopher W. Cairo
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  • T cells have been recruited to both produce and deliver vectors to specific tumors in an animal model.

    • E. Antonio Chiocca
    News & Views
  • A silk protein has now been heterologously expressed, isolated, and spun into fibers in vitro for the first time.

    • David L. Kaplan
    News & Views
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