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Nature Biotechnology
ISSUE
December 2002, Volume 20 No 12
In This Issue
Editorial
Business and Regulatory NewsAnalysis | In Brief
OpinionCommentary | Fool's Corner | Book Review | Correspondence
Feature
Research NewsNews and Views | In Brief
ResearchArticles | Technical Reports
ResourcesPatents | People | New on the Market
NaturejobsCareers and Recruitment
About the cover
In This Issue Top
PDF
Editorial Top
Pride comes before a fall (and a bloodbath) p1173
doi:10.1038/nbt1202-1173
Full text | PDF (47K)
Business and Regulatory News Top
Analysis
European Commission rethinks biotech patents pp1175 - 1176
Peter Mitchell
doi:10.1038/nbt1202-1175
Full text | PDF (69K)
Surprise US election results may boost biotech p1176
Jeffrey L. Fox
doi:10.1038/nbt1202-1176a
Full text | PDF (60K)
Japanese council urges reform of funding system pp1176 - 1178
Robert Triendl
doi:10.1038/nbt1202-1176b
Full text | PDF (80K)
Tissue engineering firms go under pp1178 - 1179
Aaron Bouchie
doi:10.1038/nbt1202-1178
Full text | PDF (443K)
Agbiotech issues climb US political agenda pp1179 - 1180
Jeffrey L. Fox
doi:10.1038/nbt1202-1179
Full text | PDF (444K)
Study critiques corporate control of trials p1180
Eric Niiler
doi:10.1038/nbt1202-1180
Full text | PDF (61K)
In Brief
In Brief pp1181 - 1183
doi:10.1038/nbt1202-1181
Full text | PDF (789K)
Opinion Top
Commentary
Shares in the human genome—the future of patenting DNA pp1185 - 1188
Sandy M. Thomas, Michael M. Hopkins & Max Brady
doi:10.1038/nbt1202-1185
Full text | PDF (80K)
Antibody evolution beyond Nature pp1189 - 1190
Carl A.K. Borrebaeck & Mats Ohlin
doi:10.1038/nbt1202-1189
Full text | PDF (76K)
Fool's Corner
The margin of safety p1191
Tom Jacobs
doi:10.1038/nbt1202-1191
Full text | PDF (47K)
Book Review
Step back from the trees p1193
Reviewed by: Larry E. Gundersen
doi:10.1038/nbt1202-1193
Full text | PDF (379K)
Correspondence
Divergent perspectives on GM food pp1195 - 1196
Roger Beachy, Jeffrey L. Bennetzen, Bruce M. Chassy, Maarten Chrispeels, Joanne Chory, Joseph R. Ecker, Joseph P. Noel, Steve A. Kay, Caroline Dean, Chris Lamb, Jonathan Jones, Charles R. Santerre, Julian I. Schroeder, Jim Umen, Martin Yanofsky, Susan Wessler, Yunde Zhao & Wayne Parrott
doi:10.1038/nbt1202-1195
Full text | PDF (778K)
Divergent perspectives on GM food - Letter 2 p1196
Alex Avery
doi:10.1038/nbt1202-1196
Full text | PDF (762K)
Reply to 'Divergent perspectives on GM food' p1197
doi:10.1038/nbt1202-1197a
Full text | PDF (52K)
Expectations and reality in gene repair pp1197 - 1198
Kyonggeun Yoon, Olga Igoucheva & Vitali Alexeev
doi:10.1038/nbt1202-1197b
Full text | PDF (601K)
Feature Top
Reconstructing pharmaceutical instinct pp1199 - 1203
John Hodgson
doi:10.1038/nbt1202-1199
Abstract | Full text | PDF (89K)
Research News Top
News and Views
Killers come to the rescue pp1205 - 1206
Marie Wahren-Herlenius & Vijay K. Kuchroo
doi:10.1038/nbt1202-1205
Abstract | Full text | PDF (325K)
See also: Research by Jyothi et al.
Tumor reactive T cells get a boost pp1207 - 1208
Drew M. Pardoll
doi:10.1038/nbt1202-1207
Abstract | Full text | PDF (109K)
See also: Research by Kershaw et al.
Signposts on the neural path pp1208 - 1210
David Gottlieb
doi:10.1038/nbt1202-1208
Abstract | Full text | PDF (184K)
See also: Research by Aubert et al.
It takes three to tango pp1210 - 1212
Olga Lomovskaya, Helen I. Zgurskaya & Hiroshi Nikaido
doi:10.1038/nbt1202-1210
Abstract | Full text | PDF (3,372K)
In Brief
In Brief p1213
doi:10.1038/nbt1202-1213
Full text | PDF (237K)
Research Top
Articles
Targeting autoantigen-specific T cells and suppression of autoimmune encephalomyelitis with receptor-modified T lymphocytes pp1215 - 1220
M. Divya Jyothi, Richard A. Flavell & Terrence L. Geiger
Published online: 11 November 2002 | doi:10.1038/nbt758
Abstract | Full text | PDF (281K)
See also: Research News by Wahren-Herlenius & Kuchroo
Dual-specific T cells combine proliferation and antitumor activity pp1221 - 1227
Michael H. Kershaw, Jennifer A. Westwood & Patrick Hwu
Published online: 04 November 2002 | doi:10.1038/nbt756
Abstract | Full text | PDF (133K)
See also: Research News by Pardoll
Systemically delivered antisense oligomers upregulate gene expression in mouse tissues pp1228 - 1233
Peter Sazani, Federica Gemignani, Shin-Hong Kang, Martin A. Maier, Muthiah Manoharan, Magnus Persmark, Donna Bortner & Ryszard Kole
Published online: 11 November 2002 | doi:10.1038/nbt759
Abstract | Full text | PDF (996K)  | Supplementary Information
Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice pp1234 - 1239
Vincent O. Mallet, Claudia Mitchell, Jacques-Emmanuel Guidotti, Patrick Jaffray, Monique Fabre, David Spencer, Damien Arnoult, Axel Kahn & Hélène Gilgenkrantz
Published online: 18 November 2002 | doi:10.1038/nbt762
Abstract | Full text | PDF (3,167K)
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation pp1240 - 1245
Jerôme Aubert, Hannah Dunstan, Ian Chambers & Austin Smith
Published online: 25 November 2002 | doi:10.1038/nbt763
Abstract | Full text | PDF (2,703K)  | Supplementary Information
See also: Research News by Gottlieb
Growth factor engineering by degenerate homoduplex gene family recombination pp1246 - 1250
Wayne M. Coco, Lance P. Encell, William E. Levinson, Michael J. Crist, A. Katrina Loomis, Laura L. Licato, Joseph J. Arensdorf, Nicole Sica, Philip T. Pienkos & Daniel J. Monticello
Published online: 11 November 2002 | doi:10.1038/nbt757
Abstract | Full text | PDF (344K)
Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently pp1251 - 1255
Jon E. Ness, Seran Kim, Andrea Gottman, Rob Pak, Anke Krebber, Torben V. Borchert, Sridhar Govindarajan, Emily C. Mundorff & Jeremy Minshull
Published online: 11 November 2002 | doi:10.1038/nbt754
Abstract | Full text | PDF (732K)  | Supplementary Information
Starch content and yield increase as a result of altering adenylate pools in transgenic plants pp1256 - 1260
Babette Regierer, Alisdair R. Fernie, Franziska Springer, Alicia Perez-Melis, Andrea Leisse, Karin Koehl, Lothar Willmitzer, Peter Geigenberger & Jens Kossmann
Published online: 11 November 2002 | doi:10.1038/nbt760
Abstract | Full text | PDF (773K)
Technical Reports
BMP4 initiates human embryonic stem cell differentiation to trophoblast pp1261 - 1264
Ren-He Xu, Xin Chen, Dong S. Li, Rui Li, Gregory C. Addicks, Clay Glennon, Thomas P. Zwaka & James A. Thomson
Published online: 11 November 2002 | doi:10.1038/nbt761
Abstract | Full text | PDF (1,615K)  | Supplementary Information
Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences pp1265 - 1268
Geert De Jaeger, Stanley Scheffer, Anni Jacobs, Mukund Zambre, Oliver Zobell, Alain Goossens, Ann Depicker & Geert Angenon
Published online: 04 November 2002 | doi:10.1038/nbt755
Abstract | Full text | PDF (645K)
Resources Top
Patents
Patent searches for genetic sequences: How to retrieve relevant records from patented sequence databases pp1269 - 1271
Guillaume Dufresne, László Takács, Hendrik C. Heus, Jean-Jacques Codani & Manuel Duval
doi:10.1038/nbt1202-1269
Abstract | Full text | PDF (133K)
Recent patents in antibacterials p1273
doi:10.1038/nbt1202-1273
Full text | PDF (30K)
People
People p1275
doi:10.1038/nbt1202-1275
Full text | PDF (191K)
New on the Market
Centrifuges and Antibodies pp1277 - 1279
doi:10.1038/nbt1202-1277
Full text | PDF (2,214K)
Naturejobs Top
Careers and Recruitment
Calling for entrepreneurs: London pp1281 - 1282
Paul Smaglik
doi:10.1038/nbt1202-1281
Abstract | Full text | PDF (49K)
  Top
 
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Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
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