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Nature Biotechnology  20, 1205 - 1206 (2002)
doi:10.1038/nbt1202-1205

Killers come to the rescue

Marie Wahren-Herlenius1 & Vijay K. Kuchroo2

1  Marie Wahren-Herlenius is an assistant professor, Center for Molecular Medicine, Department of Medicine Karolinska Institutet, S-171 76, Stockholm, Sweden

2  Vijay K. Kuchroo is an associate professor, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115 vkuchroo@rics.bwh.harvard.edu

T cells genetically modified to express a peptide−MHC complex, normally involved in the induction of autoimmunity, can kill pathogenic T cells and inhibit autoimmune disease.

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REVIEWS
EPITOPE SPREADING IN IMMUNE-MEDIATED DISEASES: IMPLICATIONS FOR IMMUNOTHERAPY
Nature Reviews Immunology Review (01 Feb 2002)
Selection and fine-tuning of the autoimmune T-cell repertoire
Nature Reviews Immunology Review Article (01 Jul 2002)

RESEARCH
Targeting autoantigen-specific T cells and suppression of autoimmune encephalomyelitis with receptor-modified T lymphocytes
Nature Biotechnology Research (01 Dec 2002)

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Nature Biotechnology
ISSN: 1087-0156
EISSN: 1546-1696
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