 | Figure 1
Nature Biotechnology
20, 1140 - 1145 (2002)
Published online: 7 October 2002; | doi:10.1038/nbt747
Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and  -glutamylcysteine synthetase expressionOm Parkash Dhankher, Yujing Li, Barry P. Rosen, Jin Shi, David Salt, Julie F. Senecoff, Nupur A. Sashti
& Richard B. Meagher | | | | Figure 1. ArsC- and  -ECS-catalyzed reactions.
The bacterial arsenate reductase (ArsC) catalyzes the electrochemical reduction of arsenate to arsenite. The bacterial  -glutamylcysteine synthetase (-ECS) catalyzes the formation of -glutamylcysteine (-EC) from the amino acids glutamate and cysteine and is the committed step in the synthesis of glutathione (GSH) and phytochelatins (PCs; indicated by three arrows). Reduced arsenite can bind organic thiols (RS) such as those in -EC, GSH, and PCs.
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