Rapidly resolving the pharmacokinetic and toxicological properties of drug candidates remains a key challenge for drug developers.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
GC–MS Analysis, Molecular Docking and Pharmacokinetic Properties of Phytocompounds from Solanum torvum Unripe Fruits and Its Effect on Breast Cancer Target Protein
Applied Biochemistry and Biotechnology Open Access 13 October 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lazarou, J., Pomeranz, B.H., & Corey, P.N. Incidence of adverse drug reactions in hospitalised patients. J. Am. Med. Assoc. 279, 1200–1205 (1998).
Lehman Brothers & McKinsey & Co. The Fruits of Genomics. (Lehman Brothers, New York, 2001).
Bowen, W.P. et al. Measurement of cytochrome P450 gene induction in human hepatocytes using quantitative real-time reverse transcriptase-polymerase chain reaction. Drug Met. Dis. 28, 781–788 (2000).
Rights and permissions
About this article
Cite this article
Hodgson, J. ADMET—turning chemicals into drugs. Nat Biotechnol 19, 722–726 (2001). https://doi.org/10.1038/90761
Published:
Issue Date:
DOI: https://doi.org/10.1038/90761
This article is cited by
-
Identifying β-secretase 1 (BACE1) inhibitors from plant-based compounds: an approach targeting Alzheimer’s therapeutics employing molecular docking and dynamics simulation
Molecular Diversity (2023)
-
Screening the possible anti-cancer constituents of Hibiscus rosa-sinensis flower to address mammalian target of rapamycin: an in silico molecular docking, HYDE scoring, dynamic studies, and pharmacokinetic prediction
Molecular Diversity (2023)
-
An investigation of binding interactions of tumor-targeted peptide conjugated polyphenols with the kinase domain of ephrin B4 and B2 receptors
Molecular Diversity (2023)
-
Computational Binding Analysis of Ethyl 3,3,5,5-Tetracyano-2-Hydroxy-2-Methyl-4,6-Diphenylcyclohexane-1-Carboxylate in Calf Thymus DNA
Applied Biochemistry and Biotechnology (2023)
-
Discovery of potential mTOR inhibitors from Cichorium intybus to find new candidate drugs targeting the pathological protein related to the breast cancer: an integrated computational approach
Molecular Diversity (2023)