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Volume 19 Issue 6, June 2001

A colorized electronmicrograph of an immature dendritic cell with two apoptotic bodies within it's phagolysosome (Reproduced with permission from Albert, Sauter & Bhardwaj, Nature 392 86–89, 1998) superimposed onto an electromicrograph of murine skeletal muscle © David Phillips. Image provided by Photo Researchers. On page 543, Robinson and colleagues describe an apoptosis inducing DNA vaccine that enhances antigenic presentation by dendritic cells.

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Feature

  • New biotechnology initiatives in Texas will lay the foundation for the growth and expansion of the industry in the southern state.

    • Dorothy Mehrens
    • Sara Hart
    Feature
  • Estonia is using its genes as bait for foreign investment to support its embryonic biotechnology industry.

    • Lone Frank
    Feature
  • Israel's biotechnology industry is bottom heavy—big on ideas but, so far, not on accomplishments. It needs to get its investors and scientists to talk.

    • Haim Watzman
    • Susan Petersen Avitzour
    Feature
  • Singapore hopes to become the R&D and manufacturing hub for the East Asian biotechnology industry, but it may find that its past success in IT does not predict future success in biotechnology.

    • Robert Triendl
    • Renee Yoon
    Feature
  • Once chilled by unfavorable economic policies, and depleted by a brain drain to the United States, Ontario is making a comeback in the business of biotechnology.

    • Hugh McIntyre
    Feature
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News & Views

  • Induction of apoptotic death by modified caspases enhances the function of “naked” DNA vaccination.

    • Nicholas P. Restifo
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  • The targeted disruption of two genes in sheep confirms the feasibility of gene targeting in large animals, but falls short of producing viable offspring.

    • Kevin Wells
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  • The genetic selection of mutant cells in a glycoconjugate biosynthetic pathway may provide insights into metabolic disease.

    • Pauline M. Rudd
    • Ghislain Opdenakker
    • Raymond A. Dwek
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  • Two new approaches offer the means to expand the repertoire of amino acids available for protein engineering.

    • Nina Mejlhede
    • Peter E. Nielsen
    • Michael Ibba
    News & Views
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