Nature Biotechnology
18, 609 - 613 (2000)
doi:10.1038/76443
Who's your neighbor? New computational approaches for functional genomicsMichael Y. Galperin
& Eugene V. Koonin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda MD 20894, USA
Correspondence should be addressed to Eugene V. Koonin koonin@ncbi.nlm.nih.govprotein function predictiongene sequenceRosetta Stoneclusters of orthologsphylogenetic patternsSeveral recently developed computational approaches in comparative genomics go beyond sequence comparison. By analyzing phylogenetic profiles of protein families, domain fusions, gene adjacency in genomes, and expression patterns, these methods predict many functional interactions between proteins and help deduce specific functions for numerous proteins. Although some of the resultant predictions may not be highly specific, these developments herald a new era in genomics in which the benefits of comparative analysis of the rapidly growing collection of complete genomes will become increasingly obvious.
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