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| Opinion |  Top |
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| Editorials |
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Accidental death of a bubble p469
doi:10.1038/75231
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(90K)
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Intellectual propriety p469
doi:10.1038/75233
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(90K)
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| Commentary |
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The practical problems of post-genomic biology pp471 - 472
Sui Huang
doi:10.1038/75235
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(100K)
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| Correspondence |
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Anhydrobiotic engineering p473
Arcadio Garcia de Castro, Jens Lapinski
& Alan Tunnacliffe
doi:10.1038/75237
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(118K)
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Reply to "Anhydrobiotic engineering" p473
doi:10.1038/75240
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(118K)
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| Erratum | Top |
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Errata p473
doi:10.1038/75242
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(118K)
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| In Brief | Top |
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| Business and Regulatory News |
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GM roundup p475
John Hodgson
doi:10.1038/75244
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(115K)
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Genome debate continues p475
Julie Grisham
doi:10.1038/75246
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(115K)
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Therapeutic cloning OK p475
Julie Grisham
doi:10.1038/75248
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(115K)
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Two SNP deals for Gemini p475
John Hodgson
doi:10.1038/75250
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(115K)
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Anti-biotech protest p475
Julie Grisham
doi:10.1038/75252
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(115K)
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Biopharmaceutical sector performance, 1st quarter 2000 p476
doi:10.1038/75255
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(103K)
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Initial public offerings, 1st quarter 2000 p476
doi:10.1038/75258
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USDA testing lab planned p476
Jeffrey L. Fox
doi:10.1038/75261
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(103K)
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Public GM plant safety program p476
Sabine Louët
doi:10.1038/75263
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(103K)
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DuPont sues Monsanto p476
Eric Niiler
doi:10.1038/75265
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(103K)
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The advisory committee strikes back p476
John Hodgson
doi:10.1038/75267
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(103K)
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Biotech fundraising, Q1 2000 p477
Emma Dorey
doi:10.1038/75268
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(183K)
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Gene chip battle p477
Eric Niiler
doi:10.1038/75272
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(183K)
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Biotech info campaign p477
Jeffrey L. Fox
doi:10.1038/75274
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(183K)
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Cartoon p477
doi:10.1038/75276
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(183K)
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Research collaborations p477
doi:10.1038/75279
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(183K)
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| Research News |
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New antibiotics show some backbone p479
Alan Dove
doi:10.1038/75282
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(101K)
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Drug smugglers come under umbrella p479
Andrew Marshall
doi:10.1038/75284
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(101K)
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Array for membrane proteins p479
Alan Dove
doi:10.1038/75286
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(101K)
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Transgenic pest control on the fly p479
Alan Dove
doi:10.1038/75289
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(101K)
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Genetic testing of the other half p479
Alan Dove
doi:10.1038/75291
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(101K)
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| This Month in Biotechnology |
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AAV divides and conquers p480
Judy Jamison
doi:10.1038/75293
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(128K)
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Drawing a bead on bioassays p480
Natalie DeWitt
doi:10.1038/75296
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(128K)
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Immunostimulatory DNA vaccines give tumor therapy a boost p480
Natalie DeWitt
doi:10.1038/75298
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(128K)
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Antisense treatment for psoriasis p480
Natalie DeWitt
doi:10.1038/75300
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(128K)
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Screening protein libraries for new activities p480
Judy Jamison
doi:10.1038/75303
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(128K)
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Feedback regulation in metabolic engineering p480
Judy Jamison
doi:10.1038/75306
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(128K)
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Antisense branches into high amylose starch p481
Judy Jamison
doi:10.1038/75308
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(134K)
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Chimeric oligonucleotides—a tool for crop improvement? p481
Natalie DeWitt
doi:10.1038/75311
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(134K)
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Tapping into tumor immunotherapy p481
Natalie DeWitt
doi:10.1038/75314
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(134K)
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A tool for identifying proteasome inhibitors p481
Natalie DeWitt
doi:10.1038/75316
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(134K)
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Technical Report p481
Natalie DeWitt
doi:10.1038/75319
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(134K)
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Review p481
Andrew Marshall
doi:10.1038/75322
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(134K)
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| Analysis | Top |
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| Business and Regulatory News |
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First round to Amgen in EPO battle p483
Debra Robertson
doi:10.1038/75324
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(101K)
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Monsanto releases rice data to academia p484
Eric Niiler
doi:10.1038/75327
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(99K)
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GM food regulatory terms debated pp484 - 485
Asako Saegusa
doi:10.1038/75329
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(105K)
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NAS report: strengthen agbio regs and relations p486
Jeffrey L. Fox
doi:10.1038/75331
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(101K)
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USDA biotech advisory panel plots uncertain course p486
Jeffrey L. Fox
doi:10.1038/75333
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(101K)
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EU Court overrules France's Bt maize ban p487
Sabine Louët
doi:10.1038/75335
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(103K)
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Biotech companies adapt to big pharma mergers pp487 - 488
Eric Niiler
doi:10.1038/75337
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(110K)
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Neuer Markt drives IPOs in Europe pp488 - 489
Ingeborg Spillman-Fürst
doi:10.1038/75339
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(103K)
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Experts disagree over color of biomass p490
Alan Dove
doi:10.1038/75341
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(101K)
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| News and Views |
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Problem solving for tumor immunotherapy pp491 - 492
Cécile Gouttefangeas
& Hans-Georg Rammensee
doi:10.1038/75343
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(151K)
See also: Research by Cho et al. | Research by Alimonti et al. |
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In defense of complete genomes pp493 - 494
Julian Parkhill
doi:10.1038/75346
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(176K)
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Probing the proteasome pathway pp494 - 496
Alfred L. Goldberg
doi:10.1038/75349
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(148K)
See also: Research by Dantuma et al. |
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Expanding the AAV package pp497 - 498
Richard Jude Samulski
doi:10.1038/75352
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(119K)
See also: Research by Nakai et al. |
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| Feature | Top |
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Public biotech 99: the numbers pp499 - 503
Riku Lähteenmäki
& John Hodgson
doi:10.1038/75355
Abstract | Full text | PDF
(128K)
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| Research | Top |
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| Review |
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The use of single-nucleotide polymorphism maps in pharmacogenomics pp505 - 508
Jeanette J. McCarthy
& Rolf Hilfiker
doi:10.1038/75360
Abstract | Full text | PDF
(141K)
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| Articles |
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Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity
by a T-helper cell-independent mechanism pp509 - 514
Hearn Jay Cho, Kenji Takabayashi, Pei-Ming Cheng, Minh-Duc Nguyen, Maripat Corr, Stephen Tuck
& Eyal Raz
doi:10.1038/75365
Abstract | Full text | PDF
(180K)
See also: Analysis by Gouttefangeas & Rammensee |
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TAP expression provides a general method for improving the recognition
of malignant cells in vivo pp515 - 520
Judy Alimonti, Qian-Jin Zhang, Reinhard Gabathuler, Gregor Reid, Susan S. Chen
& Wilfred A. Jefferies
doi:10.1038/75373
Abstract | Full text | PDF
(255K)
See also: Analysis by Gouttefangeas & Rammensee |
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Reversal of epidermal hyperproliferation in psoriasis by insulin-like
growth factor I receptor antisense oligonucleotides pp521 - 526
Christopher J. Wraight, Paul J. White, Sandra C. McKean, Rhys D. Fogarty, Daryl J. Venables, Ingrid J. Liepe, Stephanie R. Edmondson
& George A. Werther
doi:10.1038/75382
Abstract | Full text | PDF
(476K)
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Increasing the size of rAAV-mediated expression cassettes in vivo by
intermolecular joining of two complementary vectors pp527 - 532
Hiroyuki Nakai, Theresa A. Storm
& Mark A. Kay
doi:10.1038/75390
Abstract | Full text | PDF
(424K)
See also: Analysis by Samulski |
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Improving lycopene production in Escherichia coli by engineering metabolic control pp533 - 537
William R. Farmer
& James C. Liao
doi:10.1038/75398
Abstract | Full text | PDF
(597K)
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Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent
proteolysis in living cells pp538 - 543
Nico P. Dantuma, Kristina Lindsten, Rickard Glas, Marianne Jellne
& Maria G. Masucci
doi:10.1038/75406
Abstract | Full text | PDF
(952K)
See also: Analysis by Goldberg |
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Using an AraC-based three-hybrid system to detect biocatalysts in vivo pp544 - 547
Steven M Firestine, Frank Salinas, Andrew E Nixon, Stephen J Baker
& Stephen J Benkovic
doi:10.1038/75414
Abstract | Full text | PDF
(308K)
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A new microvolume technique for bioaffinity assays using two-photon excitation pp548 - 550
Pekka Hänninen, Aleksi Soini, Niko Meltola, Juhani Soini, Jori Soukka
& Erkki Soini
doi:10.1038/75421
Abstract | Full text | PDF
(209K)
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Production of very-high-amylose potato starch by inhibition of SBE A
and B pp551 - 554
Gerhard P. Schwall, Richard Safford, Roger J. Westcott, Roger Jeffcoat, Akash Tayal, Yong-Cheng Shi, Michael J. Gidley
& Stephen A. Jobling
doi:10.1038/75427
Abstract | Full text | PDF
(700K)
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Engineering herbicide-resistant maize using chimeric RNA/DNA oligonucleotides pp555 - 558
Tong Zhu, Kathryn Mettenburg, David J. Peterson, Laura Tagliani
& Chris L. Baszczynski
doi:10.1038/75435
Abstract | Full text | PDF
(314K)
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| Errata |
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Erratum to "Synthesis of positional-scanning libraries of fluorogenic
peptide substrates to define the extended substrate specificity of plasmin
and thrombin" p559
doi:10.1038/75441
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(240K)
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Erratum to 'Identification of a neuritogenic ligand of the neural cell
adhesion molecule using a combinatorial library of synthetic peptides"
p559
doi:10.1038/75444
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(240K)
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Erratum to "Germline transformation of the silkworm Bombyx moriL.
using a piggyBac transposon-derived vector" p559
doi:10.1038/75446
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(240K)
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Erratum to "Identification and expression of isoflavone synthase,
the key enzyme for biosynthesis of isoflavones in legumes"
p559
doi:10.1038/75448
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(240K)
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Erratum to "Embryonic stem cell lines from human blastocysts: somatic
differentiation in vitro" p559
doi:10.1038/75450
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(240K)
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| Technical Report |
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Universal DNA array detection of small insertions and deletions in
BRCA1 and BRCA2 pp561 - 564
Reyna Favis, Joseph P. Day, Norman P. Gerry, Catherine Phelan, Steven Narod
& Francis Barany
doi:10.1038/75452
Abstract | Full text | PDF
(504K)
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| Resources | Top |
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| Patents |
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Maximizing profits through intelligent planning and implementation pp565 - 566
John P. Isacson
doi:10.1038/75458
Abstract | Full text | PDF
(97K)
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Recent patents in green fluorescent protein research p567
doi:10.1038/75461
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(68K)
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| People |
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People p568
doi:10.1038/75464
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(87K)
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| New Products |
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New Products p569
doi:10.1038/75468
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(170K)
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| Industry Trends |
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Spin-offs versus start-ups as business models in biotechnology pp570 - 571
Aris Persidis
& Francesco De Rubertis
doi:10.1038/75476
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(91K)
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